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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform显示文摘 | Mulac-Jericevic B Lydon JP DeMayo FJ | 2003 | Proe Natl Acad Sci USA2003，，100： | 1 |
| 3 | Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function 显示文摘 | Yan C N Wang P DeMayo J | 2001 | Mol Endocrinol2001，15，6： | 1 |
| 4 | The role of CC10 in Pulmonary carcinogenesis: From a marker to tumor suppression显示文摘 | Linnoila RI Szabo E Demayo F | 2000 | Ann N Y Acad sci2000，923，： | 1 |
| 5 | Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function显示文摘 | Yan C N Wang P DeMayo J | 2001 | Mol Endocrinol2001，15，6： | 1 |
| 6 | Prostate cancer in a transgenic mouse 显示文摘 | GREENBERG N M DEMAYO F FINEGOLD M J | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 7 | Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform显示文摘 | Jericevic BM Mullinax RA DeMayo FJ | 2000 | Science2000，289，： | 1 |
| 8 | Myogenic vector expression of insulin-like growth factor Ⅰ stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice显示文摘 | Coleman M E Demayo F Yin K C | 1995 | J Biol Chem1995，270，12： | 1 |
| 9 | Production of interleukin-1 by polymorphonuclear leukocytes resident in periradicular tissue显示文摘 | Miller GA Demayo T Hutter JW | 1996 | J Endod1996，22，： | 1 |
| 10 | Toxic effects of lead and lead compounds on human health, aquatic life, wildlife, plants, and livestock 显示文摘 | Demayo A Taylor M C Taylor K W | 1982 | Crit Rev Environ Control1982，12，4： | 1 |
| 11 | Sexual dimorphism in body shape of Hypseleotris Agilis (Herre, 1927)from Lake Lanao, Philippines显示文摘 | Nacua S S Torres M A J Demayo C G | 2012 | J Biol Sci2012，，1： | 1 |
| 12 | Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function显示文摘 | Yan C Wang P DeMayo J | 2001 | Mol Endocrinol2001，15，6： | 1 |
| 13 | The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice显示文摘 | GREENBERG N M DEMAYO F J SHEPPARD P C | 1994 | Mol Endocrinol1994，8，2： | 1 |
| 14 | Expression of SV40 T antigen under control of rabbit uteroglobin promoter in trans- genic miee显示文摘 | DeMayo FJ Finegold MJ Hansen TN | 1991 | Am J Physiol1991，261，21： | 1 |
| 15 | C/EBPalpha is re-quired for differentiation of white,but not brown adipose tissue显示文摘 | Linhart H G Ishimura-Oka K Demayo F | 2001 | PNAS2001，98，12： | 1 |
| 16 | The regulation of embryoimplantation and endometrial decidualization by progesteronereceptor signaling 显示文摘 | Large MJ DeMayo FJ | 2012 | Mol Cell Endocrinol2012，358，： | 1 |
| 17 | C/EBPalpha is required for differentiation of white,but not brown adipose tissue显示文摘 | Linhart H G Ishimura-Oka K DeMayo F | 2001 | PNAS2001，98，12： | 1 |
| 18 | C/EBPalpha is required for differentiation of white,but not brown,adipose tissue显示文摘 | Linhart H G Ishimura-Oka K DeMayo F | 2001 | Proc Natl Acad Sci2001，98，12： | 1 |
| 19 | Liver-specific deletion of acetyl-CoA carboxylase 1reduces hepatic triglyceride accumulation without affecting glucose homeostasis显示文摘 | Mao J Demayo F J Li H | 2006 | Proc Natl Acad Sci USA2006，103，22： | 1 |
| 20 | Myogenic vectot expression of insulin like growth factor Ⅰ stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice 显示文摘 | COLEMAN M E DEMAYO F YIN K C | 1995 | J Biol Chem1995，270，12： | 1 |
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