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| 1 | Contribution of oxidative stress to pulmonary arterial hypertension显示文摘Recent data implicate oxidative stress as a mediator of pulmonary hypertension (PH) and of the associated pathological changes to the pulmonary vasculature and right ventricle (RV). Increases in reactive oxygen species (ROS), altered redox state, and elevated oxidant stress have been demonstrated in the lungs and RV of several animal models of PH, including chronic hypoxia, monocrotaline toxicity, caveolin-1 knock-out mouse, and the transgenic Ren2 rat which overexpresses the mouse renin gene. Generation of ROS in these models is derived mostly from the activities of the nicotinamide adenine dinucleotide phosphate oxidases, xanthine oxidase, and uncoupled endothelial nitric oxide synthase. As disease progresses circulating monocytes and bone marrow-derived monocytic progenitor cells are attracted to and accumulate in the pulmonary vasculature. Once established, these inflammatory cells generate ROS and secrete mitogenic and fibrogenic cytokines that induce cell proliferation and fibrosis in the vascular wall resulting in progressive vascular remodeling. Deficiencies in antioxidant enzymes also contribute to pulmonary hypertensive states. Current therapies were developed to improve endothelial function, reduce pulmonary artery pressure, and slow the progression of vascular remodeling in the pulmonary vasculature by targeting deficiencies in either NO (PDE-type 5 inhibition) or PGI 2 (prostacyclin analogs), or excessive synthesis of ET-1 (ET receptor blockers) with the intent to improve patient clinical status and survival. New therapies may slow disease progression to some extent, but long term management has not been achieved and mortality is still high. Although little is known concerning the effects of current pulmonary arterial hypertension treatments on RV structure and function, interest in this area is increasing. Development of therapeutic strategies that simultaneously target pathology in the pulmonary vasculature and RV may be beneficial in reducing mortality associated with RV failure. | Vincent G DeMarco Adam T Whaley-Connell James R Sowers Javad Habibi Kevin C Dellsperger | 2010 | World Journal of Cardiology2010，2，10： | 21 |
| 2 | World Health Organization Pulmonary Hypertension Group2:pulmonary hypertension due to left heart disease in the adult-a summary statement from the Pulmonary Hypertension Council of the International Society for Heart and Lung Transplantation显示文摘 | Fang JC DeMarco T Givertz MM | | 0，，09： | 1 |
| 3 | Effects of long term biventric- ular stimulation for resynchronization on echocardiographic measures of remodeling显示文摘 | Saxon L DeMarco T Schafer J | 2002 | Circulation2002，105，11： | 1 |
| 4 | Resin bond strength to a zirconia-reinforced ceramic after different surface treatments显示文摘 | Donassollo T A Demarco F F Della Bona A | 2009 | Gen Dent2009，57，4： | 1 |
| 5 | Software risk management显示文摘 | Boehm B W DeMarco T | 1997 | Software IEEE1997，14，3： | 1 |
| 6 | An energy based security measure for assessing vulnerability to voltage collapse显示文摘 | Demarco C L Qverbye T J | 1990 | IEEE Trans on Power Systems1990，5，2： | 1 |
| 7 | Voltage Security Enhancement Using Energy Based Sensitivities显示文摘 | Overbye T J Demarco C L | 1991 | IEEE Trans on Power Systems1991，6，3： | 1 |
| 8 | Percutaneous nephrolithotomy in children显示文摘 | DEMARCO R T | 2011 | Advances in Urology2011，2011，12： | 1 |
| 9 | An energy based security measure for assessing vulnerability to voltage collapse显示文摘 | DEMARCO C L QVERBYE T J | 1990 | IEEE Transactions on Power Systems1990，5，2： | 1 |
| 10 | Monocytes promote natural killer cell interferon gamma production in responseto the endogenous danger signal HMGB1显示文摘 | DeMarco R A Fink M P Lotze M T | 2005 | Mol Immunol2005，42，4： | 1 |
| 11 | Voltage security enhancement using energy based sensitivities显示文摘 | Overbye T J Demarco C L | 1991 | IEEE Trans on Power Systems1991，6，3： | 1 |
| 12 | An Extended Kalman Filter Approach to Rotor Time Constant Mea- surement in Pwm Induction Motor Drives显示文摘 | ZAI L C DEMARCO C L LIPO T A | 1992 | Industry Ap- plications IEEE Transactions on1992，28，1： | 1 |
| 13 | An Energy Based Security Measure for Assessing Vulnerability to Voltage Collapse显示文摘 | OVERBYE T J | 1990 | IEEE Transactions on Power Systems1990，5，2： | 1 |
| 14 | Catheter fracture and embolization in a totally implanted venous aecess catheter 显示文摘 | Franey T DeMarco LC Geiss AC | 1988 | J Parenter Enteral Nutr1988，12，5： | 1 |
| 15 | An Energy Based Security Measure for Assessing Vulnerability to Voltage Collapse显示文摘 | DEMARCO C L OVERBYE T J | 1990 | IEEE Transactions on Power Systems1990，5，2： | 1 |
| 16 | Voltage security enhancement using energy based sensitivities显示文摘 | OVERBYE T J DEMARCO C L | 1991 | IEEE Transactions on Power Systems1991，6，3： | 1 |
| 17 | Q - V curve inter- pretation of energy measure for voltage security 显示文摘 | OVERBYE T J DOBSON I DEMARCO C L | 1994 | IEEE Trans- actions on Power Systems1994，9，1： | 1 |
| 18 | A Monte Carlo tutorial and the application for radiotherapy treatment planning 显示文摘 | J J Demarco I J Chetty T D Solberg | 2002 | Medical Dosimetry (S0958-3947)2002，27，1： | 1 |
| 19 | A genome-wide RNAi screen in Caenorhabditis elegans identifies the nicotinic acetylcholine receptor subunit ACR-7 as an antipsychotic drug target显示文摘 | SAUR T DEMARCO S E ORTIZ A et d | 2013 | PLoS Genetics2013，9，10： | 1 |
| 20 | Oxidative stress contributes to pulmonary hypertension in the transgenic (mren2) 27 rat 显示文摘 | DeMarco V G Habibi J Whaley-Connell A T | 2008 | Am J Physiol Heart Circ Physiol2008，294，6： | 1 |
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