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| 1 | Using lysosomal membrane stability of haemocytes in Ruditapes philippinarum as a biomarker of cellular stress to assess contamination by caffeine, ibuprofen, carbamazepine and novobiocin显示文摘Although pharmaceuticals have beendetected in the environment only in the range from ng/L to μg/L, it has beendemonstrated that they can adversely affect the health status of aquatic organisms. Lysosomal membrane stability (LMS) has previously been applied as an indicator of cellularwell-being todetermine health status in bivalve mussels. The objective of this study is to evaluate LMS in Ruditapes philippinarum haemolymph using the neutral red retention assay (NRRA). Clamswere exposed in laboratory conditions to caffeine (0.1, 5, 15, 50 μg/L), ibuprofen (0.1, 5, 10, 50 μg/L), carbamazepine and novobiocin (both at 0.1, 1, 10, 50 μg/L) for35days. Results show adose-dependent effect of the pharmaceuticals. The neutral red retention time measured at the end of the bioassaywas significantly reduced by 50% after exposure to environmental concentrations (p < 0.05) (caffeine = 15 μg/L; ibuprofen = 10 μg/L; carbamazepine = 1 μg/L and novobiocin = 1 μg/L), compared to controls. Clams exposed to these pharmaceuticalswere considered to present adiminished health status (retention time <45 min), significantlyworse than controls (96 min) (p < 0.05). The predicted no environmental effect concentration (PNEC) results showed that these pharmaceuticals are very toxic at the environmental concentrations tested. Measurement of the alteration of LMS has been found to be a sensitive technique that enables evaluation of the health status of clams after exposure to pharmaceuticals under laboratory conditions, thus representing a robust Tier-1 screening biomarker. | Gabriela V. Aguirre-Martínez Sara Buratti Elena Fabbri Angel T. DelValls M. Laura Martín-Díaz | 2013 | Journal of Environmental Sciences2013，25，7： | 6 |
| 2 | Bed rest or normal activity for patients with acute low back pain:a randomized controlled trial显示文摘 | Rozenberg S Delval C Rezvani Y | 2002 | Spine2002，27，： | 1 |
| 3 | Deter- mining contamination sources in marine sediments u- sing multivariate analysis 显示文摘 | DelValls T A Forja J M Gonz~lez-Mazo E | 1998 | Trends in Analytical Chemistry1998，7，： | 1 |
| 4 | Toxicity arid bioaccumulation of copper and lead in five marine microalgae显示文摘 | DEBELIUS B FORJA J M DELVALLS A etal | 2009 | Ecotoxicology and Environmental Safety2009，72，5： | 1 |
| 5 | Using sediment quality guidelines for dredged material management in commercial ports from Spain显示文摘 | M.C. Casado-Martínez J.L. Buceta M.J. Belzunce T.A. DelValls | 2005 | Environment International2005，，3： | 1 |
| 6 | Extraction kinetics of prepelletized Jalapeno peppers with supercritical CO2显示文摘 | Delvalle J M Jinénez M | 2003 | Supercritical Fluids2003，25，1： | 1 |
| 7 | Analysis of macrobenthic community structure in relation to different environmental sources of contamination in two littoral ecosystems from the Gulf of Cádiz (SW Spain)显示文摘 | T.A. DelValls M. Conradi E. Garcia-Adiego J.M. Forja A. Gómez-Parra | 1998 | Hydrobiologia1998，，1： | 1 |
| 8 | The application of a weight of evidence approach to compare the quality of coastal sediments affected by acute ( Prestige 2002) and chronic (Bay of Algeciras) oil spills显示文摘 | Carmen Morales-Caselles Inmaculada Riba Carmen Sarasquete T. ángel DelValls | 2008 | Environmental Pollution2008，，2： | 1 |
| 9 | Ecological risk assessment of sediment management areas: application to Sado Estuary显示文摘 | CAEIRO S COSTA M H DELVALL A | 2009 | Portugal Ecotoxicology2009，18，： | 1 |
| 10 | The dendritic cell-specific chemokine,dendritic cell-derived CC chemokine 1,enhances protective cell-mediated immunity to murine malaria显示文摘 | Bruna-Romero O Schmieg J DelVal M | 2003 | Immunol2003，170，6： | 1 |
| 11 | Determining contamination sources in marine sediments using multivariate analysis显示文摘 | DelValls T A Forja J M Gonza E lez-Mazo E | 1998 | Trends in analytical chemistry1998，17，： | 1 |
| 12 | Integrated assessment of sediment quality in two littoral ecosystems from the Gulf of Ca' diz, Spain 显示文摘 | DelValls T A Forja J M GoPmez-Parra A | 1998 | EnviranrnontM Toxicology and Chemistry1998，17，6： | 1 |
| 13 | Mould inhibition in tortilla by dimethyl fumarate 显示文摘 | Islam M N Lirio M E Delvalle F R | 1984 | J Food Proc Preserv1984，8，1： | 1 |
| 14 | Optimization of the microstreture for improving superplastic forming in magnesium alloys显示文摘 | DELVALLE J A PENALBA F RUANO O A | 2007 | Materials Science and Engineering A2007，467，： | 1 |
| 15 | Evaluating the heavy metal contamination in sediments from the Guadalquivir estuary after the Aznalco' llar mining spill (SW Spain):a multivariate analysis approach显示文摘 | Riba 1 DelValls T A Forja J M | | 0，，： | 1 |
| 16 | Distribution of arsenic and trace metals in the floodplain agricultural soil of Bangladesh显示文摘 | Dewan All Ahsan Tomas Angel DelValls | 2009 | Bull Environ Contam Toxicol2009，82，： | 1 |
| 17 | Influence of Zn concentration in the activity of Cd1-xZnxS solid solutions for water splitting under visible light 显示文摘 | DELVALLE F ISHIKAWA A DOMEN K | 2009 | Catal Today2009，143，12： | 1 |
| 18 | Methylphenidate for gaithypokinesia and freezing in patients with Parkinson's diseaseundergoing subthalamic stimulation: a multicentre, parallel,randomised, placebo-controlled trial显示文摘 | Moreau C Delval A Defebvre L | 2012 | Lancet Neurol2012，11，7： | 1 |
| 19 | Brachytherapy for pediatric soft-tissue sarcoma显示文摘 | Merchant TE Parsh N Delvalle PL | 2000 | Int J Radiat Oncol Biol Phys2000，46，2： | 1 |
| 20 | Toxicity and potential risk assessment of a river polluted by acid mine drainage in the Iberian Pyrite Belt(SW Spain)显示文摘 | Sarmiento A M DelValls A Nieto J M | 2011 | Science of the Total Environment2011，409，： | 1 |
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