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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide显示文摘 | MORALE M C SERRA P A DELOGU M R | 2004 | FASEB J2004，18，1： | 1 |
| 3 | Serum neopterin and soluble interlekin-2 receptor for prediction of a shock state in gram-negative sepsis显示文摘 | Delogu G Casula M A Maneini P | 1995 | J Crit Care1995，10，2： | 1 |
| 4 | Patients with pulmonary tuber- culosis develop a strong humoral response against methylated heparin-binding hemagglutinin 显示文摘 | Zanetti S Bua A Delogu G | 2005 | Clin Diagn Lab Immunol2005，12，9： | 1 |
| 5 | Kinetics of amorphization processes by mechanical alloying: a modeling approach 显示文摘 | DELOGU F COCCO G | 2007 | Journal of Alloys and Compounds2007，436，12： | 1 |
| 6 | Uptake and agro- nomic efficiency of nitrogen in winter barley and winter wheat显示文摘 | Delogu G Cattivelli L Pecchioni N | 1998 | European Journal of Agronomy1998，9，1： | 1 |
| 7 | Heparin-binding hemaggluti-nin HBHA from Mycobacterium tuberculosis affects actin polymeris- ation显示文摘 | Esposito C Marasco D Delogu G | 2011 | Bioehem Biophys Res Commun2011，410，2： | 1 |
| 8 | Synthesis and biocatalytic resolution of a new atropisomeric thiobiphenyl : ( 2,2,6,6- tetramethoxybiphenyl-3,3-diyl ) dimethanethiol 显示文摘 | Sanfilippo C Nicolosi G Delogu G | 2005 | Tetrahedron : Asymmetry2005，16，6： | 1 |
| 9 | Grain yield, nitrogen-use efficiency and baking quality of old and modem Italian bread- wheat cultivars grown at different nitrogen levels显示文摘 | Guarda G Padovan S Delogu G | 2004 | Euro- pean Journal of Agronomy2004，21，2： | 1 |
| 10 | NH3-CO2- H2O VLE calculation using an extended UNIQUAC equa- tion显示文摘 | BERNARDIS M CARVOLI G DELOGU P | 1989 | AICHE J1989，35，2： | 1 |
| 11 | The PE mutigene family:a ' molecular mantra' for Mycobacteria 显示文摘 | MICHAEL J BRENNAN GIOVANNI DELOGU | 2002 | Trends in Microbiology2002，10，5： | 1 |
| 12 | Heat shock proteins and their role in heart injury 显示文摘 | DELOGU G SIGNORE M MECHELLI A | 2002 | Curr Opin Crit Care2002，8，5： | 1 |
| 13 | Ecological aspects of influenza A virus circulation in wild birds of the western palearctic显示文摘 | Delogu M De Marco MA Donatelli I | 2003 | Veterinary Research Communications2003，27，1： | 1 |
| 14 | DNA vaccination against tuberculosis:expression of a ubiquitin-conjugted tuberculosis protein enhance antimycobacterial immunity显示文摘 | Delogu G Howard A | 2000 | Infect Immun2000，68，6： | 1 |
| 15 | Functional domains present in the mycobacterial hemagglutinin,HBHA显示文摘 | Delogu G Brennan MJ | 1999 | J Bacteriol1999，181，24： | 1 |
| 16 | Ureaplasma and bronchopulmonary dys- plasia显示文摘 | Gancia P Delogu A Pomero G | 2014 | Early Hum Dev2014，90，1： | 1 |
| 17 | Ceramide concentrations in septic patients: a possible marker of multiple organ dysfunction syndrome显示文摘 | Delogu G Famularo G Amati F | 1999 | Crit Care Med1999，27，11： | 1 |
| 18 | The mycobacterial heparin-bind- ing hemagglutinin is a protective antigen in the mouse aerosol chall- enge model of tuberculosis显示文摘 | Parra M Pickett T Delogu G | 2004 | Infect Immun2004，72，12： | 1 |
| 19 | De- sign for disassembly:a method-ology for identifying the opti- mal disassembly sequence 显示文摘 | Federico Cappelli Massimo Delogu Marco Pierini | 2007 | Journal of Engineering De- sign2007，18，6： | 1 |
| 20 | Comparative immune response of PE and PE-PGRS amigens of mycobacterium tuberculosis显示文摘 | Delogu G Brennan M | 2001 | Infect Immun2001，69，9： | 1 |
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