|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 2 | Detection of genetic diversity within snai lintermediated hosts of the genus Bulinus by using random amplified polymorphic DNA marker (RAPDs) 显示文摘 | Langand J Barral V Delay B | 1993 | Acta Trop1993，55，4： | 1 |
| 3 | Characterization of porcine plasma ficolins that bind Actinobacillus pleuropneumoniae serotype 5B显示文摘 | BROOKS A S DELAY J P HAYES M A | 2003 | Immunobiology2003，207，： | 1 |
| 4 | Contextual text/non-text stroke classification in online handwritten notes with conditional random fields显示文摘 | Delaye A Liu C L | 2014 | Pattern Recognition2014，47，3： | 1 |
| 5 | Effect of simvastatin on coronary atheroma: the multicentre anti-atheroma study ( MAAs ) 显示文摘 | Oliver MF Baehmann K Delaye J | 1994 | Lancet1994，344，8923： | 1 |
| 6 | From HLA- B27 to spondyloarthritis: a journey through the ER显示文摘 | Colbert R A Delay M L Klenk E L | 2010 | Immu- nol Rev2010，233，： | 1 |
| 7 | autologous latissimus breast rconstrucion:a 3-year clinical experience with 100 patients显示文摘 | Delay E Gound N bouilla A | 1998 | Plast Recondtr Surg1998，102，5： | 1 |
| 8 | Malignant gastroduodenal obstruction:palliation with self-expanding metallic stents显示文摘 | Bessoud B de Baere T Delays A | 2005 | J Vasc Interv Radiol2005，16，2： | 1 |
| 9 | Comparative study of fowl plague virus and a virus isolated from man显示文摘 | Delay PD Casey HL Tubiash HS | 1967 | Public Health Rep1967，82，7： | 1 |
| 10 | Investigation of the ki- netics of assisted potassium-ion transfer by diben- zo- 18-Crown-6 at the micro-ities by means of steady-state voltammetry 显示文摘 | Beattie P D Delay A Girault H H | 1995 | Journal of Electroanalytical Chemistry1995，380，12： | 1 |
| 11 | Immediate and long term results of valve replacement for native and prosthetic valve endocarditis显示文摘 | Delay D Pellerin M Carrier M | 2000 | Ann Thorac Surg2000，70，4： | 1 |
| 12 | Hy-poxia-induced autophagy promotes tumorcell survival and adaptation to antiangio-genic treatment in glioblastoma 显示文摘 | Hu YL Delay M Jahangiri A | 2012 | Canc-er Res2012，72，7： | 1 |
| 13 | 5D evaluation and mammary augmentation surgery 显示文摘 | b GARSON S DELAY E SINNA R | 2005 | Ann Chit Plast Esthet2005，1，50： | 1 |
| 14 | Tumor Cell Autophagy as an Adaptive Response Mediating Resistance to Treatments Such as Antiangiogenic Therapy显示文摘 | Yu-Long Hu Arman Jahangiri Michael DeLay Manish K. Aghi | 2012 | Cancer Research2012，，17： | 1 |
| 15 | Takagi- Sugeno Fuzzy Fault-Tolerant Control of an Induction Motor 显示文摘 | Lopez-Toribio C J PATTON R J DELAY S | 2000 | Neural Computing and Application2000，，1： | 1 |
| 16 | Amultipopulation genetic algorithm to solve the inverse problem in hydrogeology显示文摘 | Delay F Katsifarakis K L deMarsilyG | 2001 | Water resources research2001，，9： | 1 |
| 17 | The CD10 Enzyme Is a Key Player to Identify and Regulate Human Mammary Stem Cells 显示文摘 | Elodie BC Chapellier M Delay E | 2010 | Stem Cells2010，28，6： | 1 |
| 18 | Type A dissection in young patients显示文摘 | Niclauss L Delay D von Segesser LK | 2011 | Interact Cardiovasc Thorac Surg2011，12，2： | 1 |
| 19 | A soluble divalent class I MHC/IgG1 fusion protein activates CD8+ T cells in vivo显示文摘 | Carey B DeLay M Strasser JE | 2005 | Clinical Immunology2005，116，： | 1 |
| 20 | The effectiveness of noninvasive positive pressure ventilation to enhance preoxy- genation in morbidly obese patients: a randomized controlled study 显示文摘 | Delay JM Sebbane M Jung B | 2008 | Anesth Analg2008，107，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员