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| 1 | 代谢型谷氨酸受体可作为一种新型恶性胶质瘤治疗靶点(英文)显示文摘Objective Metabotropic glutamate receptors(mG luR)are predominantly involved in maintenance of cellular homeostasis of central nervous system.However,evidences have suggested other roles of mG luR in human tumors.Aberrant mG luR signaling has been shown to participate in transformation and maintenance of various cancer types,including malignant brain tumors.This review intends to summarize recent findings regarding the involvement of mG luR-mediated intracellular signaling pathways in progression,aggressiveness,and recurrence of malignant gliomas,mainly glioblastomas(GBM),highlighting the potential therapeutic applications of mG luR ligands.In addition to the growing number of studies reporting mG luR gene or protein expression in glioma samples(resections,lineages,and primary cultures),pharmacological blockade in vitro of mG luR1 and mG luR3 by selective ligands has been shown to be anti-proliferative and anti-migratory,decreasing activation of MAPK and PI3K pathways.In addition,mG luR3 antagonists promoted astroglial differentiation of GBM cells and also enabled cytotoxic action of temozolomide(TMZ).mG luR3-dependent TMZ toxicity was supported by increasing levels of MGMT transcripts through an intracellular signaling pathway that sequentially involves PI3K and NF-κB.Further,continuous pharmacological blockade of mG luR1 and mG luR3 have been shown to reduced growth of GBM tumor in two independent in vivo xenograft models.In parallel,low levels of mG luR3 mRNA in GBM resections may be a predictor for long survival rate of patients.Since several Phase I,II and III clinical trials are being performed using group I and II mG luR modulators,there is a strong scientifically-based rationale for testing mG luR antagonists as an adjuvant therapy for malignant brain tumors. | Pereira MS Klamt F Thomé CC Worm PV de Oliveira DL | 2017 | 中华神经外科疾病研究杂志2017，16，1： | 3 |
| 2 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 3 | Is the reliability of a visual analog scale higher than an ordinal scale? An experiment with the GRBAS scale for the perceptual evaluation of dysphonia显示文摘 | Wuyts FL De Bodt MS Van de heyning PH | 1999 | J Voice1999，13，： | 1 |
| 4 | Increase in serum prolactin by exogenous and endogenous opiates:evidence for antidopamine and antipsychotic effect显示文摘 | Gold MS Redmond DE Donabedian RK | 1978 | Am J Psychiatry1978，135，： | 1 |
| 5 | Brain corticosteroid receptor balance in health and disease显示文摘 | De Kloet ER Vreugdenhil E Oitzl MS | 1998 | Endocr Rev1998，19，3： | 1 |
| 6 | Multimarker approach to risk stratification in non- ST elevation acute coronary syndromes: simultaneous assessment of troponin I, C-reactive protein, and B-type natriuretic peptide显示文摘 | Sabatine MS Morrow DA de Lemos JA | 2002 | Circulation2002，105，15： | 1 |
| 7 | Clinician’s guide toprevention and treatment of osteoporosis 显示文摘 | Cosman F de Beur SJ Leboff MS | 2014 | Osteoporosis Int2014，，： | 1 |
| 8 | The search for abiomarker of cardiacischemia显示文摘 | Morrow DA de Lemos JA Sabatine MS | 2003 | Clin Chem2003，49，4： | 1 |
| 9 | Elevation of B-type natriuretic peptide in the setting of myocardial ischemia 显示文摘 | Sabatine MS Morrow DA de Lemos JA | 2001 | Circulation2001，104，2： | 1 |
| 10 | Clinical resenosis after coronary stenting:perspectives from multicenter clinical trials显示文摘 | Cutlip DE Chauhan MS Bairn DS | 2002 | J Am Coll Cardiol2002，40，： | 1 |
| 11 | The17q12-q21amplicon:Her2 and topoisomerase-IIalpha and their importance to the biology of solid tumours显示文摘 | Mano MS Rosa DD De Azambuja E | 2007 | Cancer Treat Rev2007，33，： | 1 |
| 12 | Cementless porous-coated anatomic total hip arthroplasty at Duke:18-to 24-year follow-up显示文摘 | Ferrell MS Browne JA Attarian DE | 2009 | J Surg Orthop Adv2009，18，3： | 1 |
| 13 | The search for a biomarker of cardiac ischemia显示文摘 | Morrow DA de Lemos JA Sabatine MS | 2003 | Clin Chem2003，49，4： | 1 |
| 14 | TUNEL and growth factor expression in the prefrontal cortex of Alzheimer patients over 80 years old显示文摘 | Lorke DE Wai MS Liang Y | 2010 | Int J Immunopathol Pharmacol2010，23，1： | 1 |
| 15 | Vascular density and distribution of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 (Flk-1) are significantly higher in patients with deeply infiltrating endometriosis affecting the rectum显示文摘 | Machado DE Abrao MS Berardo PT | 2008 | Fertil Steril2008，90，1： | 1 |
| 16 | Initial experimence using the transconjunctival sutureless vitrectomy system for vitreoreinal surgery 显示文摘 | Fujii GY De Juan E Jr Humayun MS | 2002 | Ophthalmology2002，109，10： | 1 |
| 17 | Modulation of VLA-4 and L-selectin expression on normal CD34^+ cells during mobilization with G-CSF 显示文摘 | Bellucci R De Propris MS Buccisano F | 1999 | Bone MarrowTransplant1999，23，1： | 1 |
| 18 | Endostatin inhibits murine colon carcinoma sinusoidal-type metastases by preferential targeting of hepatic sinusoidal endothelium 显示文摘 | Solaun MS Mendoza L De Luca M | 2002 | Hepatology2002，35，5： | 1 |
| 19 | Perfluoroperhydrophenanthrene versus perfluoronoctane in vitreoretinal surgery显示文摘 | Loewenstein A Humayun MS de Juan E Jr | 2000 | Ophthalmology2000，107，6： | 1 |
| 20 | Quercetin metabolites downregulate cyclooxygenase-2 transcription in human lymphocytes ex vivo but not in vivo显示文摘 | de Pascual Teresa S Johnston KL Dupont MS | 2004 | Nutr2004，134，3： | 1 |
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