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| 1 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 2 | Probable benign paroxysmal positional vertigo, spontaneously resolved:Incidence in medical practice, patients’ characteristics and the natural course显示文摘Background: Probable benign paroxysmal positional vertigo, spontaneously resolved (pBPPVsr), is a variant of benign paroxysmal positional vertigo (BPPV) in which there is no observable nystagmus and no vertigo with any positional maneuver. Objectives: To calculate the incidence pBPPVsr, compare the characteristics of the patients with pBPPVsr and BPPV not spontaneously resolved and describe the spontaneous resolution in the natural course of BPPV. Methods: Multicenter prospective descriptive study. During a one-year period, all patients with suspected BPPV that presented to the Neurotology Units of five participating centers were recruited. The incidence of pBPPVsr was calculated as a percentage of the total number of patients with BPPV. The prevalence of several variables was compared between pBPPVsr and BPPV not spontaneously resolved. The timing of spontaneous resolution was estimated using Kaplan-Meier curves. Results: 457 patients met the inclusion criteria. The incidence of pBPPVsr was 33.5%. It was significantly higher in males, in patients with normal bone mass and in patients who were not taking sulpiride. A rate of 18% of spontaneous resolution after the first month and 51% after the first year was found. This percentage did not change in a significant way after this moment. The curves for males, patients under 50 and patients with normal blood pressure decreased significantly faster. Conclusions: In our serie, BPPV spontaneously resolved in half of the patients with BPPV during the first year. This seemed to occur more commonly in males and could have been hindered by sulpiride intake, osteoporosis, advanced age and high blood pressure. | M.G.Alvarez-Morujo de Sande R. Gonzalez-Aguado G. Guerra-Jimenez E. Domenech-Vadillo H. Galera-Ruiz E. Figuerola-Massana A. Ramos-Macías C. Morales-Angulo A.J. Martín-Mateos E. Domínguez-Duran | 2019 | Journal of Otology2019，14，3： | 5 |
| 3 | 日粮中蛋白质和纤维水平对仔猪生产性能和健康状况的影响显示文摘为了研究日粮的蛋白质和纤维水平对仔猪生产性能和健康状况的互作,特选择96头35日龄的仔猪(体重为9.11±0.60kg),分32个栏饲养,每栏3头,分成4个日粮处理组,饲喂期21d。在设定的2×2因子处理中,4种日粮以大米、奶制品和大豆粕为基础配制,日粮蛋白质设两个水平(15.4%与19.4%,风干基),纤维也设两个水平[低水平纤维(LF)为含5.3%中性洗涤纤维,高水平纤维(HF)为含7.15%中性洗涤纤维,风干基]。高水平纤维日粮组在基础日粮中添加了40g/kg的小麦麸和20g/kg的甜菜浆。每周测定动物生产性能,试验第1天和最后一天收集粪样进行微生物学分析,并且按1(液态)到4(硬实)的评分体系对粪便进行评分。在试验最后1d,每栏选1头猪采集血液,分析急性期反应蛋白(acute-phase protein)和主要急性期反应蛋白(major acute-phase prot)(即Pig-MAP)的含量,随后进行屠宰,对消化道(包括内容物)进行称重,并进行结肠组织学分析。饲喂高水平纤维日粮的仔猪具有较大的平均日增重(390g与457g,P≤0.001)和大肠重量(以占体重比例衡量为4.4%与5.4%,P≤0.05)。这与较高的短链脂肪酸浓度(尤其是乙酸和丁酸)、较少的大肠杆菌数量(每克粪便含7.77与6.86logcfu,P≤0.05)和较高乳酸杆菌与肠道细菌比(0.76与1.37,P≤0.05)是相符的。虽然日粮蛋白质水平没有改变猪的生产性能,但是20%的蛋白质水平提高(P≤0.05)了小肠(6.5与7.7)和大肠(3.8与4.3)的相对重量(占体重的百分比)。在大肠内,含20%蛋白质的日粮使仔猪杯状细胞数量增加(4.6/100与5.4/100μm;P≤0.05),并使肠上皮内淋巴细胞数量减少(1.8/100与1.3/100μm;P≤0.05)。在健康状况方面,提高日粮纤维水平所产生的效果与日粮中的蛋白质含量有关。在含16%蛋白质的日粮中增加纤维水平可降低粪便评分值、增加抗生素治疗次数,然而在含20%蛋白的日粮中增加纤维水平,所产生的情况与此相反。与蛋白质含量为16%的日粮组仔猪相比,蛋白质含量为20%的日粮组仔猪血液Pig-MAP浓度较低(P≤0.05)。总的来说,日粮蛋白质对消化道重量和肠壁完整性起主要作用,然而日粮纤维可提高仔猪生产性能,并且促进了肠道微生物区系和发酵指标的改善。 | 冯占雨 R.G.Hermes F.Molist M.Ywazaki M.Nofrarías A.Gomez de Segura J.Gasa J.F.Pérez | 2009 | 国外畜牧学(猪与禽)2009，，6： | 5 |
| 4 | Differential colorectal carcinogenesis:Molecular basis and clinical relevance显示文摘Colorectal cancer(CCR) is one of the most frequent cancers in developed countries.It poses a major public health problem and there is renewed interest in understanding the basic principles of the molecular biology of colorectal cancer.It has been established that sporadic CCRs can arise from at least two different carcinogenic pathways.The traditional pathway,also called the suppressor or chromosomal instability pathway,follows the Fearon and Vogelstein model and shows mutation in classical oncogenes and tumour suppressor genes,such as K-ras,adenomatous polyposis coli,deleted in colorectal cancer,or p53.Alterations in the Wnt pathway are also very common in this type of tumour.The second main colorectal carcinogenesis pathway is the mutator pathway.This pathway is present in nearly 15% of all cases of sporadic colorectal cancer.It is characterized by the presence of mutations in the microsatellite sequences caused by a defect in the DNA mismatch repair genes,mostly in hMLH1 or hMSH2.These two pathways have clear molecular differences,which will be reviewed in this article,but they also present distinct histopathological features.More strikingly,their clinical behaviours are completely different,having the 'mutator' tumours a better outcome than the 'suppressor' tumours. | Alberto Morán Paloma Ortega Carmen de Juan Tamara Fernández-Marcelo Cristina Frías Andrés Sánchez-Pernaute Antonio José Torres Eduardo Díaz-Rubio Pilar Iniesta Manuel Benito | 2010 | World Journal of Gastrointestinal Oncology2010，2，3： | 5 |
| 5 | Robotic transanal total mesorectal excision:Is the future now?显示文摘Total mesorectal excision(TME)is the standard surgical treatment for the curative radical resection of rectal cancers.Minimally invasive TME has been gaining ground favored by the continuous technological advancements.New procedures,such as transanal TME(TaTME),have been introduced to overcome some technical limitations,especially in low rectal tumors,obese patients,and/or narrow pelvis.The earliest TaTME reports showed promising results when compared with the conventional laparoscopic TME.However,recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national series.Robotic TaTME(R-TaTME)has been proposed as a novel technique incorporating the potential benefits of a perineal dissection together with precise control of the distal margins,and also offers all those advantages provided by the robotic technology in terms of improved precision and dexterity.Encouraging short-term results have been reported for R-TaTME,but further studies are needed to assess the real role of the new technique in the long-term oncological or functional outcomes.The present review aims to provide a general overview of R-TaTME by analyzing the body of the available literature,with a special focus on the potential benefits,harms,and future perspectives for this novel approach. | Juan Carlos Sebastián-Tomás Aleix Martínez-Pérez Elías Martínez-López Nicola de'Angelis Marcos Gómez Ruiz Eduardo García-Granero | 2021 | World Journal of Gastrointestinal Surgery2021，13，8： | 2 |
| 6 | From hyperglycemia to diabetic kidney disease:the role of metabolic,hemodynamic,intracellular factors and growth factors/cytokines显示文摘 | Schrijvers BF De Vriese AS Flyvbjerg A | | 0，，6： | 2 |
| 7 | 跟骨关节内移位骨折的功能疗效和患者满意度——切开复位、经皮手术和非手术治疗对比研究显示文摘对于跟骨关节内移位骨折,约60%的工薪阶层患者会选择切开复位内固定术(openreductionandinternalfixation,ORIF)治疗,术后恢复工作通常需要5~10个月,相当一部分患者1年内无法恢复工作;而对于保守治疗患者,骨折症状通常会持续1~2年,高达16%的患者需行关节内固定手术。本研究的主要目的是比较3种跟骨关节内移位骨折治疗方案——ORIF、经皮手术和非手术治疗的疗效差异。 | De Boer AS Van Lieshout EM Den Hartog D 叶翔凌 夏远军 | 2016 | 中国骨科临床与基础研究杂志2016，8，6： | 2 |
| 8 | Robotic surgery techniques to approach benign prostatic hyperplasia disease:A comprehensive literature review and the state of art显示文摘Objective:The robotic-assisted approach to simple prostatectomy(RASP)was conceived,essentially reproducing the fundaments of open simple prostatectomy.Since the first report,RASP underwent several technical modifications.The study aims to identify and describe the current robotic surgery techniques to approach benign prostatic hyperplasia(BPH).Methods:The paper performed a non-systematic literature review accessing PubMed and Embase databases for all full-text articles published from 2008 to May 2020,assessing robot-assisted surgical techniques for BPH treatment using the terms“robot-assisted simple prostatectomy”OR“robotic simple prostatectomy”OR“RASP”AND“surgical technique”.Results:After careful review of 180 studies in PubMed and 198 in Embase,16 papers reporting different RASP techniques.After the first procedure described by Sotelo et al.[9],several authors contributed to the development of the RASP technique.John et al.[24]proposed the extraperitoneal access,and Yuh et al.[23]first reported the adenoma transcapsular dissection.Some modifications were proposed by Coelho et al.[31]on trigonization,posterior reconstruction,and urethro-vesical anastomosis.Other groups focused on urethral-preserving procedures.Moschovas et al.[28]and Clavijo et al.[32]recently described an intrafascial RASP with the removal of the entire prostatic tissue.Finally,Kaouk et al.[29]reported the feasibility and safety of the da Vinci Single Port approach.Conclusion:In the last eighteen years,the robotic-assisted approach to BPH disease has been evolved,and different techniques have been described.This review details all the technical developments on RASP that distinctive groups have proposed since the multiport robotic platforms until the new da Vinci Single Port. | Marcio Covas Moschovas Frederico Timo´teo Leonardo Lins Ose´as de Castro Neves Kulthe Ramesh Seetharam Bhat Vipul R.Patel | 2021 | Asian Journal of Urology2021，8，1： | 2 |
| 9 | Rifampin-associated acute renal failure:Pathophyiologic, immunologic, and clinical features 显示文摘 | DE VRIESE AS ROBBRECHT DL VANHOLDER RC | 1998 | Am J Kidney Dis1998，31，1： | 1 |
| 10 | Clinical and laboratory evaluation of a real-time PCR for Clostridium difficile toxin A and B genes显示文摘 | de Jong E de Jong AS Bartels C J | 2012 | Eur J Clin Microbiol Infect Dis2012，31，9： | 1 |
| 11 | Cytokine removal during continuous hemofiltration in septic patients显示文摘 | De Vriese AS Colardyn FA Philippé JJ | | 0，，04： | 1 |
| 12 | Nicotinic Acid Limitation Regulates Silencing of Candida Adhesins during UTI显示文摘 | Domergue R Casta(n)o I de Las Pe(n)as A | | 0，，5723： | 1 |
| 13 | Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination 显示文摘 | Terling TR Martire T de Almeida AS | 2007 | Pediatrics2007，120，4： | 1 |
| 14 | The role of vascular endothelial growth factor (VEGF) in renal pathophysiology显示文摘 | Schrijvers BF Flyvbjerg A De Vriese AS | 2004 | Kidney Int2004，65，： | 1 |
| 15 | Kisspeptin - GPR54 signaling is essential for preovulatory gonadotropin - releasing hormone neuron activation and the luteinizing hormone surge 显示文摘 | Clarkson J d'Anglemont de Tassigny X Moreno AS | 2008 | J Neurosci2008，28，35： | 1 |
| 16 | Expression of connexins 36,43, and 45 during postnatal development of the mouse retina显示文摘 | Kiahara AH Mantovani de Castro L Belmonte MA Yan CY Moriscot AS Hamassald DE | 2006 | J Neurobiol2006，66，13： | 1 |
| 17 | Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes显示文摘 | Tilton RG Elger M | 2001 | J Am Soc Nephro2001，112，： | 1 |
| 18 | Portal hypertensive gastropathy and gastric varices before esophageal variceal sclerotherapy and after obliteration显示文摘 | De BK Ghoshal UC Das AS | 1998 | Indian J Gastroenterol1998，17，1： | 1 |
| 19 | Antibodies against vascular endothelial growth factor improve early renal dysfunction in experimental diabetes显示文摘 | De Vriese AS Tihon RG Elger M | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 20 | In vitro evaluation of the effectiveness of ProTaper universal rotar~ retreatment system for gutta-percha removal with or withoul asolvent 显示文摘 | Takahashi CM Cunha RS de Martin AS | 2009 | J Endod2009，35，11： | 1 |
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