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| 1 | Effect of hepatocyte apoptosis induced by TNF-α on acute severe hepatitis in mouse models显示文摘AIM To study the effect of hepatocyteapoptosis and necrosis induced by TNF-α on thepathogenesis of acute severe hepatitis(ASH).METHODS The model of ASH was prepared inD-galactosamine(GAIN)sensitized BALB/c miceby injection of either endotoxin(ET)or tumornecrosis factor-α(TNF-α).Morphologicalchanges of apoptotic hepatocytes were studiedby both light and electron microscope and in siteend labeling method(ISEL).Molecular biologicalchanges of DNA ladder were observed byelectrophoresis of extract from liver tissues.Biochemical changes were measured by alanineaminotransferase(ALT),asparticaminotransferase(AST)and TNF-α.The relationbetween apoptosis and necrosis was evaluatedsimultaneously.RESULTS The sequence of hepatocyteapoptosis,necrosis,and final death from ASHwas observed both in GAIN/ET and GAIN/TNF-agroup.Apoptosis was prominent at 3.5 h and 5 hafter injection of inducer,while necrosis becamedominant at 9 h after challenge.The appearanceof apoptosis was earlier in GAIN/TNF-α groupthan that in GAIN/ ET group.Pretreatment ofmice with antiTNF IgG1 may completely preventthe liver injury induced by GalN/ET.CONCLUSION TNF-α can cause liver damageby inducing hepatic apoptosis and necrosis inmice with endotoxemia. | Guo Qing Zang Xia Qiu Zhou Hong Yu Qing Xie Guo Ming Zhao Bin Wang Qing Guo Yue Qin Xiang Dan Liao Department of Infectious Diseases,Rujin Hospital,Shanghai Second Medical University,Shanghai 200025,China | 2000 | World Journal of Gastroenterology2000，6，5： | 30 |
| 2 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 3 | Exploring an Integrative Therapy for Treating COVID-19:A Randomized Controlled Trial显示文摘Objectives:To develop a new Chinese medicine(CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome(ARDS)in COVID-19 patients.Methods:A putative ARDS-suppressing drug Keguan-1 was first developed and then evaluated by a randomized,controlled two-arm trial.The two arms of the trial consist of a control therapy(alpha interferon inhalation,50(x g twice daily;and lopinavir/ritonavir,400 and 100 mg twice daily,respectively)and a testing therapy(control therapy plus Keguan-119.4 g twice daily)by random number table at 1:1 ratio with 24 cases each group.After 2-week treatment,adverse events,time to fever resolution,ARDS development,and lung injury on newly diagnosed COVID-19 patients were assessed.Results:An analysis of the data from the first 30 participants showed that the control arm and the testing arm did not exhibit any significant differences in terms of adverse events.Based on this result,the study was expanded to include a total of 48 participants(24 cases each arm).The results show that compared with the control arm,the testing arm exhibited a significant improvement in time to fever resolution(P=0.035),and a significant reduction in the development of ARDS(P=0.048).Conclusions:Keguan-1-based integrative therapy was safe and superior to the standard therapy in suppressing the development of ARDS in COVID-19 patients.(Trial registration No.NCT 04251871 at www.clinicaltrials.gov). | WANG Jia-bo WANG Zhong-xia JING Jing ZHAO Peng DONG Jing-hui ZHOU Yong-feng YANG Guang NIU Ming ZHAO Xu JIANG Tian-jun Bl Jing-feng XU Zhe ZHANG Ping WU Dan BAI Zhao-fang GUO Yu-ming YU Si-miao SUN Yong-qiang ZHANG Zi-teng ZHAN Xiao-yan LI Peng-yan DING Jin-biao ZHAO Peng-fei SONG Xue-ai TANG Jian-yuan HE Dong-chu CHEN Zhu QIN En-qiang WANG Rui-lin XIAO Xiao-he | 2020 | Chinese Journal of Integrative Medicine2020，26，9： | 18 |
| 4 | MiR-27a Promotes Hepatocellular Carcinoma Cell Proliferation Through Suppression of its Target Gene Peroxisome Proliferator-activated Receptor γ显示文摘 | Shuo Li Jing Li Bing-Yuan Fei Dan Shao Yue Pan Zhan-Hao MO Bao-Zhen Sun Dan Zhang Xiao Zheng Ming Zhang Xue-Wen Zhang Li Chen | 2015 | Chinese Medical Journal2015，，7： | 15 |
| 5 | Structured illumination microscopy for super-resolution and optical sectioning显示文摘Optical microscopy plays an essential role in biological studies due to its capability and compatibility of non-contact,minimally invasive observation and measurement of live specimens.However,the conventional optical microscopy only has a spatial resolution about200 nm due to the Abbe diffraction limit,and also lacks the ability of three-dimensional imaging.Super-resolution farfield optical microscopy based on special illumination schemes has been dramatically developed over the last decade.Among them,only the structured illumination microscopy(SIM)is of wide-field geometry that enables it easily compatible with the conventional optical microscope.In this article,the principle of SIM was introduced in terms of point spread function(PSF)and optical transform function(OTF)of the optical system.The SIM for super-resolution(SIM-SR)proposed by Gustafsson et al.and the SIM for optical sectioning(SIM-OS)proposed by Neil et al.are the most popular ones in the research community of microscopy.They have the same optical configuration,but with different data postprocessing algorithms.We mathematically described the basic theories for both of the SIMs,respectively,and presented some numerical simulations to show the effects of super-resolution and optical sectioning.Various approaches to generation of structured illumination patterns were reviewed.As an example,a SIM system based on DMDmodulation and LED-illumination was demonstrated.A lateral resolution of 90 nm was achieved with gold nanoparticles.The optical sectioning capability of the microscope was demonstrated with Golgi-stained mouse brain neurons,and the sectioning strength of 930 nm was obtained. | Dan Dan Baoli Yao Ming Lei | 2014 | Chinese Science Bulletin2014，59，12： | 14 |
| 6 | Pretreatment neutrophil-to-lymphocyte and platelet-to- lymphocyte ratios do not predict survival in patients with cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy显示文摘 | WANG Dan WU Ming FENG Feng-zhi HUANG Hui-fang YANG Jia-xin SHEN Keng XIANG Yang | 2013 | Chinese Medical Journal2013，，8： | 10 |
| 7 | A new iridoid glycoside from Gardenia jasminoides显示文摘新 iridoid glycoside, 6 ′ - O-sinapoylgeniposide,从栀子 jasminoides 埃利斯被孤立,它的结构根据 1D 和 2D NMR 被阐明, HR-ESI-MS 技术。 | Xiao Qin Zhou Zhi Ming Bi Ping Li Dan Tang Hal Xia Cai | 2007 | Chinese Chemical Letters2007，18，10： | 10 |
| 8 | Development and Validation of a Model for Predicting Diabetic Nephropathy in Chinese People显示文摘Objective To develop a risk model for predicting later development of diabetic nephropathy(DN)in Chinese people with type 2 diabetes mellitus(T2DM)and evaluate its performance with independent validation.Methods We used data collected from the project‘Comprehensive Research on the Prevention and Control of Diabetes’,which was a community-based study conducted by the Jiangsu Center for Disease Control and Prevention in 2013.A total of 11,771 eligible participants were included in our study.The endpoint was a clear diagnosis of DN.Data was divided into two components:a training set for model development and a test set for validation.The Cox proportional hazard regression was used for survival analysis in men and women.The model’s performance was evaluated by discrimination and calibration.Results The incidence(cases per 10,000 person-years)of DN was 9.95(95%CI;8.66-11.43)in women and 11.28(95%CI;9.77-13.03)in men.Factors including diagnosis age,location,body mass index,high-density-lipoprotein cholesterol,creatinine,hypertension,dyslipidemia,retinopathy,diet control,and physical activity were significant in the final model.The model showed high discrimination and good calibration.Conclusion The risk model for predicting DN in people with T2DM can be used in clinical practice for improving the quality of risk management and intervention. | MIAO Dan Dan PAN En Chun ZHANG Qin SUN Zhong Ming QIN Yu WU Ming | 2017 | Biomedical and Environmental Sciences2017，30，2： | 8 |
| 9 | Relief Effect of Bevacizumab on Severe Edema Induced by Re-irradiation in Brain Tumor Patients显示文摘INTRODUCTION Brain edema is a serious clinical event and could cause various neurological symptoms such as dizziness and headache.Drugs frequently used to relieve brain edema include steroid,dehydrant (e.g.,mannitol),and diuretics.But the effects of these drugs were limited in patients with severe edema.Bevacizumab has been applied in the treatment of cerebral radiation necrosis.[1] Case studies have reported on the application of bevacizumab in the treatment of severe brain edema.[2] In the present study,we describe significant effects of bevacizumab on severe brain edema in patients with re-irradiation. | Ge Shen Ying-Jie Wang Yan-Jun Guan Da-Peng Dong Gang Yang Dan Li Rui-Min Hao Hui-Ru Sun Ming Zhou Kun-Peng Wang Shi-Xiang Zhou Qin-Wen Wang Shi-Kai Wu Yan-Jun Zeng | 2015 | Chinese Medical Journal2015，，15： | 7 |
| 10 | Two new saponins from the aerial part of Astragalus membranaceus var. mongholicus显示文摘Two new saponins named mongholicoside A (1) and mongholicoside B (2) were isolated from the aerial part of Astragalus membranaceus var. mongholicus. Their structures were determined by 1D and 2D NMR, ESI-MS techniques and chemical methods. | Qing Tao Yu Ping Li Zhi Ming Bi Jun Luo Xiao Dan Gao | 2007 | Chinese Chemical Letters2007，18，5： | 7 |
| 11 | The Association of Socioeconomic Status with the Burden of Cataract-related Blindness and the Effect of Ultraviolet Radiation Exposure: An Ecological Study显示文摘Objective To assess the association of socioeconomic status with the burden of cataract blindness in terms of year lived with disability(YLD) rates and to determine whether ultraviolet radiation(UVR) levels modify the effect of socioeconomic status on this health burden.Methods National and subnational age-standardized YLD rates associated with cataract-related blindness were derived from the Global Burden of Disease(GBD) study 2017. The human development index(HDI) from the Human Development Report was used as a measure of socioeconomic status.Estimated ground-level UVR exposure was obtained from the Ozone Monitoring Instrument(OMI)dataset of the National Aeronautics and Space Administration(NASA).Results Across 185 countries, socioeconomic status was inversely associated with the burden of cataract blindness. Countries with a very high HDI had an 84% lower age-standardized YLD rate [95%confidence interval(CI): 60%–93%, P < 0.001] than countries with a low HDI;for high-HDI countries, the proportion was 76%(95% CI: 53%–88%, P < 0.001), and for medium-HDI countries, the proportion was48%(95% CI: 15%–68%, P = 0.010;P for trend < 0.001). The interaction analysis showed that UVR exposure played an interactive role in the association between socioeconomic status and cataract blindness burden(P value for interaction = 0.047).Conclusion Long-term high-UVR exposure amplifies the association of poor socioeconomic status with the burden of cataract-related blindness. The findings emphasize the need for strengthening UVR exposure protection interventions in developing countries with high-UVR exposure. | DENG Yan YANG Dan YU Jia Ming XU Jing Xian HUA Hui CHEN Ren Tong WANG Nan OU Feng Rong LIU Ru Xi WU Bo LIU Yang | 2021 | Biomedical and Environmental Sciences2021，34，2： | 6 |
| 12 | Holistic Service-Based Architecture for Space-Air-Ground Integrated Network for 5G-Advanced and Beyond显示文摘The Service-based Architecture(SBA) is one of the key innovations of 5G architecture that leverage modularized, self-contained and independent services to provide flexible and cloud-native 5G network. In this paper, SBA for Space-Air-Ground Integrated Network(SAGIN) is investigated to enable the 5G integration deployment. This paper proposes a novel Holistic Service-based Architecture(H-SBA)for SAGIN of 5G-Advanced and beyond, i.e., 6G. The H-SBA introduces the concept of end-to-end servicebased architecture design. The 'Network Function Service', introduced in 5G SBA, is extended from Control Plane to User Plane, from core network to access network. Based on H-SBA, the new generation of protocol design is proposed, which proposes to use IETF QUIC and SRv6 to substitute 5G HTTP/2.0 and GTP-U. Testing results show that new protocols can achieve low latency and high throughput, making them promising candidate for H-SBA. | Xiaoyun Wang Tao Sun Xiaodong Duan Dan Wang Yongjing Li Ming Zhao Zhigang Tian | 2022 | China Communications2022，19，1： | 6 |
| 13 | Generative adversarial networks (GAN) based efficient sampling of chemical composition space for inverse design of inorganic materials显示文摘A major challenge in materials design is how to efficiently search the vast chemical design space to find the materials with desired properties.One effective strategy is to develop sampling algorithms that can exploit both explicit chemical knowledge and implicit composition rules embodied in the large materials database.Here,we propose a generative machine learning model(MatGAN)based on a generative adversarial network(GAN)for efficient generation of new hypothetical inorganic materials.Trained with materials from the ICSD database,our GAN model can generate hypothetical materials not existing in the training dataset,reaching a novelty of 92.53% when generating 2 million samples.The percentage of chemically valid(charge-neutral and electronegativitybalanced)samples out of all generated ones reaches 84.5% when generated by our GAN trained with such samples screened from ICSD,even though no such chemical rules are explicitly enforced in our GAN model,indicating its capability to learn implicit chemical composition rules to form compounds.Our algorithm is expected to be used to greatly expand the range of the design space for inverse design and large-scale computational screening of inorganic materials. | Yabo Dan Yong Zhao Xiang Li Shaobo Li Ming Hu Jianjun Hu | 2020 | npj Computational Materials2020，，1： | 5 |
| 14 | Stannous-acetylacetonate:A new catalyst for poly(trimethylene terephthalate) synthesis显示文摘Stannous-acetylacetonate was prepared efficiently and characterized by 1H NMR and FT-IR. Its catalytic activity for poly(trimethylene terephthalate) (PTT) synthesis was investigated. By this catalyst, the degree of esterification of pure terephthalic acid was up to 91.7% after reaction at 260°C for 2 h, while the intrinsic viscosity and content of ter- minal carboxyl groups of the corresponding PTT polymerized at 260°C, 60 Pa for 2 h was 0.8816 dL/g and 17 mol/t, respectively. Stannous-acetylacetonate was more active and promising than tetrabutyl titanate and stannous octoate for PTT synthesis. | Shu Yong Jia Yu Rong Ren Liang Ming Liu Dan Zhang Yi Zeng Gong Ying Wang | 2007 | Chinese Chemical Letters2007，18，7： | 5 |
| 15 | The protective effects of Polygonum multiflorum stilbeneglycoside preconditioning in an ischemia/reperfusion model of HUVECs显示文摘 | Li-ping LIU Zhang-ping LIAO Dong YIN Wei-dong LI Dan LIU Qing LI Qi-ren HUANG Yao-fang YANG Ming HE | 2010 | Acta Pharmacologica Sinica2010，31，4： | 5 |
| 16 | Environmental and Psycho-social Factors Related to Prostate Cancer Risk in the Chinese Population:a Case-control Study显示文摘Objective To study the risk environmental and psycho-social factors associated to prostate cancer(PCa) in Chinese population. Methods 250 PCa patients and 500 controls were enrolled in this case-control study. Information was collected and logistic regression analysis was used to estimate the odds ratios(OR) and 95% confidence intervals(95% CI) for relationship between lifestyle, eating habits and psycho-social factors with PCa risk. Results Green vegetables and green tea were associated with a decreased risk of PCa(OR=0.39, 95% CI: 0.28-0.53; OR=0.59, 95% CI: 0.40-0.87, respectively). Family history of PCa(OR=7.16, 95% CI: 2.01-25.49), history of prostate diseases(OR=2.28, 95% CI: 1.53-3.41), alcohol consumption(OR=1.97, 95% CI: 1.33-2.90), red meat consumption(OR=1.74, 95% CI: 1.20-2.52), barbecued(OR=2.29, 95% CI: 1.11-4.73) or fried(OR=2.35, 95% CI: 1.24-4.43) foods were related with increased PCa risk. Negative psycho-social factors including occupational setbacks(OR=1.61, 95% CI: 1.00-2.59), marital separation(OR=1.94, 95% CI: 1.29-2.91), self-contained suffering(OR=2.37, 95% CI: 1.58-3.55), and high sensitivity to the personal comments(OR=1.73, 95% CI: 1.18-2.54) were related to PCa. Conclusion Regular consumption of green vegetables and green tea may suggest protective effects on PCa. Alcohol consumption, red meat consumption and barbecued or fried foods were associated with PCa. Negative psycho-social factors may also play a role in the incidence of PCa in Chinese population. | LI Mei Ling LIN Ji HOU Jian Guo XU Lei CUI Xin Gang XU Xing Xing YU Yong Wei HAN Xue WANG Guo Min GUO Jian Ming XU Dan Feng THOMPSON Timothy C CAO Guang Wen ZHANG Hong Wei | 2014 | Biomedical and Environmental Sciences2014，27，9： | 5 |
| 17 | Integrated agronomic practice increases maize grain yield and nitrogen use efficiency under various soil fertility conditions显示文摘Crop yield potential can be increased through the use of appropriate agronomic practices. Integrated agronomic practice (IAP) is an effective way to increase maize (Zea mays L.) grain yield and nitrogen use efficiency (NUE);however, the physiological processes associated with gains in yield potential obtained from IAP, particularly the different under various soil fertility conditions, remain poorly understood. An IAP strategy including optimal planting density, split fertilizer application, and subsoiling tillage was evaluated over two growing seasons to determine whether the effects of IAP on maize yield and NUE differ under different levels of soil fertility. Compared to farmers' practices (FP), IAP increased maize grain yield in 2013 and 2014 by 25% and 28%, respectively, in low soil fertility (LSF) fields and by 36% and 37%, respectively, in high soil fertility (HSF) fields. The large yield gap was attributed mainly to greater dry matter (DM) and N accumulation with IAP than with FP owing to increased leaf area index (LAI) and DM accumulation rate, which were promoted by greater soil mineral N content (Nmin) and root length. Post-silking DM and N accumulation were also greater with IAP than with FP under HSF conditions, accounting for 60% and 43%, respectively, of total biomass and N accumulation;however, no significant differences were found for post-silking DM and N accumulation between IAP and FP under LSF conditions. Thus, the increase in grain yield with IAP was greater under HSF than under LSF. Because of greater grain yield and N uptake, IAP significantly increased N partial factor productivity, agronomic N efficiency, N recovery efficiency, and physiological efficiency of applied N compared to FP, particularly in the HSF fields. These results indicate that considerable further increases in yield and NUE can be obtained by increasing effective soil N content and maize root length to promote post-silking N and DM accumulation in maize planted at high plant density, especially in fields with low soil fertility. | Baoyuan Zhou Xuefang Sun Dan Wang Zaisong Ding Congfeng Li Wei Ma Ming Zhao | 2019 | The Crop Journal2019，7，4： | 5 |
| 18 | Wind estimation around the shipwreck of Oriental Star based on field damage surveys and radar observations显示文摘Based on observational analyses and on-site ground and aerial damage surveys, this work aims to reveal the weather phenomena—especially the wind situation—when Oriental Star capsized in the Yangtze River on June 1, 2015.Results demonstrate that the cruise ship capsized when it encountered strong winds at speeds of at least 31 m s^(-1) near the apex of a bow echo embedded in a squall line. As suggested by the fallen trees within a 2-km radius around the wreck location,such strong winds were likely caused by microburst straight-line wind and/or embedded small vortices, rather than tornadoes. | Zhiyong Meng Dan Yao Lanqiang Bai Yongguang Zheng Ming Xue Xiaoling Zhang Kun Zhao Fuyou Tian Mingjun Wang | 2016 | Science Bulletin2016，61，4： | 5 |
| 19 | Chemical and Isotopic Characters of the Water and Suspended Particulate Materials in the Yellow River and Their Geological and Environmental Implications显示文摘The chemical and isotopic characteristics of the water and suspended particulate materials(SPM)in the Yellow River were investigated on the samples collected from 29 hydrological monitoring stations in the mainstem and several major tributaries during 2004 to 2007.TheδD andδ^(18)O values of the Yellow River water vary in large ranges from-32‰to-91‰and from-3.1‰to-12.5‰,respectively.The characters of H and O isotope variations indicate that the major sources of the Yellow River water are meteoric water and snow melting water,and water cycle in the Yellow River basin is affected strongly by evaporation process and human activity.The average SPM content(9.635g/L)of the Yellow River is the highest among the world large rivers.Compared with the Yangtze River,the Yellow River SPM has much lower clay content and significantly higher contents of clastic silicates and carbonates.In comparison to the upper crust rocks,the Yellow River SPM contains less SiO_2,CaO,K_2O and Na_2O,but more TFe_2O_3,Co,Ni,Cu,Zn,Pb and Cd.The abnormal high Cd contents found in some sample may be related to local industrial activity.The REE contents and distribution pattern of the Yellow River SPM are very close to the average value of the global shale.The averageδ^(30)Si_(SPM)in the Yellow River(-0.11‰)is slightly higher than the average value(-0.22‰)of the Yangtze River SPM.The major factors controlling theδ^(30)Si_(SPM)of the Yellow River are the soil supply,the isotopic composition of the soil and the climate conditions.The TDS in the Yellow River are the highest among those of world large rivers.Fair correlations are observed among Cl^-,Na^+,K^+,and Mg^(2+)contents of the Yellow River water,indicating the effect of evaporation.The Ca^(2+)and Sr^(2+)concentrations show good correlation to the SO_4^(2-)concentration rather than HCO_3^-concentration,reflecting its origin from evaporates.The NO_3^-contents are affected by farmland fertilization.The Cu,Zn and Cd contents in dissolved load of the Yellow River water are all higher than those of average world large rivers,reflecting the effect of human activity.The dissolved load in the Yellow River water generally shows a REE distribution pattern parallel to those for the Yangtze River and the Xijiang River.Theδ^(30)Si values of the dissolved silicon vary in a range from 0.4‰to 2.9‰,averaging1.34‰.The major processes controlling the D_(Si)andδ^(30)Si_(Diss)of the Yellow River water are the weathering process of silicate rocks,growth of phytolith in plants,evaporation,dissolution of phytolith in soil,growth of fresh water diatom,adsorption and desorption of aqueous monosilicic acid on iron oxide and human activities.The averageδ^(30)Si_(Diss)value of the Yellow River is significantly lower than that of the Nile River,Yangtze River and Siberia rivers,but higher than those of other rivers,reflecting their differences in chemical weathering and biological activity.Theδ^(34)S_(SO4)values of the Yellow River water range from-3.8‰to 14.1‰,averaging 7.97‰.There is some correlation between SO_4^(2-)content andδ^(34)S_(SO4).The factors controlling theδ^(34)S_(SO4)of the Yellow River water are the SO_4 in the meteoric water,the SO_4 from gypsum or anhydrite in evaporite rocks,oxidation and dissolution of sulfides in the mineral deposits,magmatic rocks and sedimentary rocks,the sulfate reduction and precipitation process and the sulfate from fertilizer.The^(87)Sr/^(86)Sr ratios of all samplesrange from 0.71041 to 0.71237,averaging 0.71128.The variations in the^(87)Sr/^(86)Sr ratio and Sr concentration of river water are primarily caused by mixing of waters of various origins with different^(87)Sr/^(86)Sr ratios and Sr contents resulting from water-rock interaction with different rock types. | DING Tiping GAO Jianfei TIAN Shihong WANG Huaibai LI Ming WANG Chengyu LUO Xurong HANG Dan | 2016 | Acta Geologica Sinica(English Edition)2016，90，1： | 4 |
| 20 | The toxic effect of solubilizing excipients on Tetrahymena thermophila BF_5 growth investigated by microcalorimetry显示文摘The toxic effect of different solubilizing excipients on the growth and metabolism of Tetrahymena thermophila BF5(T.t.BF5) at various concentrations was investigated by microcalorimetry.The thermogenic curves of T.t.BF5 growth were determined at 28°C,and were evaluated by dynamic parameters.The results indicated that the values of growth rate constant(k),maximum power(P1,P2),peak time(T1,T2) and total quantity of heat(Q) varied for different excipients.There was a good linear relationship between k and concentrations(r>0.95,P<0.01).5% inhibition concentration(IC5) of poloxamer 188,Tween 80,PEG 600,PEG 400 and Tween 20 was 2.18,1.07,1.35,0.58,and 0.045 mg/mL,respectively.After the principal component analysis(PCA),Q,k and P1 could characterize the effect of these excipients on T.t.BF5 growth.Comprehensive evaluation indicated that compared with the control group,poloxamer 188 had the weakest toxicity and Tween 20 had the strongest toxicity. | ZHANG ShaoFeng YAN Dan TANG HuiYing YANG Ming WANG YueSheng XIAO XiaoHe | 2010 | Chinese Science Bulletin2010，55，18： | 4 |
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