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| 1 | Natural herbal medicine Lianhuaqingwen capsule anti-influenza A (H1N1) trial: a randomized, double blind, positive controlled clinical trial显示文摘背景 2009 流行性感冒 A (H1N1 ) 病毒感染与严重复杂并发症的高风险被联系并且比另外的报导季节的流行性感冒在整个 wodd 更快正在传播。试图评估在病人的草药的药 Lianhuaqingwen 囊( LHC )与 16-65 年的 244 个病人的一个总数由实时 RT-PCR 与流行性感冒 A ( H1N1 )病毒感染证实了的流行性感冒 A ( H1N1 ) virus.Methods 感染了的性质的功效和安全的这研究被使随机化到之一二治疗各 122 组织病人。每个组分配了收到 LHC 或 Oseltamivir 五天和观察七天。如果他们有 37.4 并且与至少一下列症状的腋的温度,病人在 36 小时病发作以内被注册:鼻音阻塞,流鼻涕的鼻子,咳嗽,酸的喉咙,疲劳,头疼,肌痛,寒冷并且出汗。主要结束点是 244 个病人,的 illness.Results 的持续时间 240 (98.36 ) 有 21 年完成了的中部的年龄的病人在 10 月 24,2009 日和 2009 年 11 月 23 日之间的学习。对待的 LHC 之间没有重要全面差别, Oseltamivir 在病(LHC 69 小时对 Oseltamivir 85 小时 P 0.05 ) 的中部的持续时间或病毒的流的中部的持续时间对待病人(LHC 103 小时对 Oseltamivir 96 小时, P 0.05 ) 。然而,注意 LHC 显著地包括发烧,咳嗽,酸的喉咙,和疲劳(P 0.05 ) 减少了病和症状的持续时间的严厉是值得的。两学习药很好被容忍。没有药联系了严肃的不利事件与 Oseltamivir 相比发生在 study.Conclusions 期间, LHC 完成了病的持续时间和病毒的流的持续时间的类似的治疗学的有效性减小。因此, LHC 可能是为流行性感冒 A (H1N1 ) 病毒感染的一项其他的治疗学的措施。(临床的试用数字:ChiCTR-TRC-00000589 ) 。 | DUAN Zhong-ping JIA Zhen-hua ZHANG Jian LIU Shuang CHEN Yu LIANG Lian-chun ZHANG Chang-qing ZHANG Zong SUN Yan ZHANG Shu-qin WANG Yong-yan WU Yi-ling | 2011 | Chinese Medical Journal2011，，18： | 55 |
| 2 | SDF-1/CXCR4 axis modulates bone marrow mesenchymal stem cell apoptosis, migration and cytokine secretion显示文摘Bone marrow mesenchymal stem cells(MSCs)are considered as a promising cell source to treat the acute myocardial infarction.However,over 90%of the stem cells usually die in the first three days of transplantation.Survival potential,migration ability and paracrine capacity have been considered as the most important three factors for cell transplantation in the ischemic cardiac treatment.We hypothesized that stromal-derived factor-1(SDF-1)/CXCR4 axis plays a critical role in the regulation of these processes.In this study,apoptosis was induced by exposure of MSCs to H2O2 for 2 h.After re-oxygenation,the SDF-1 pretreated MSCs demonstrated a significant increase in survival and proliferation.SDF-1 pretreatment also enhanced the migration and increased the secretion of pro-survival and angiogenic cytokines including basic fibroblast growth factor and vascular endothelial growth factor.Western blot and RT-PCR demonstrated that SDF-1 pretreatment significantly activated the pro-survival Akt and Erk signaling pathways and up-regulated Bcl-2/Bax ratio.These protective effects were partially inhibited by AMD3100,an antagonist of CXCR4.We conclude that the SDF-1/CXCR4 axis is critical for MSC survival,migration and cytokine secretion. | Xiaolei Liu Biyan Duan Zhaokang Cheng Xiaohua Jia Lina Mao Hao Fu Yongzhe Che Lailiang Ou Lin Liu Deling Kong | 2011 | Protein & Cell2011，2，10： | 53 |
| 3 | Control of Grain Size and Weight by the OsMKKK10-OsM KK4-OsMAPK6 Signaling Pathway in Rice显示文摘谷物尺寸是在庄稼决定谷物产量的关键农学的特点之一。然而,在庄稼位于谷物尺寸控制下面的机制留下逃犯。这里,我们证明断然表明小径的 OsMKKK10-OsMKK4-OsMAPK6 在米饭调整谷物尺寸和重量。在米饭,当组成地活跃的 OsMKKK10 (CA-OsMKKK10 ) 的 overexpression 导致大、重的谷物,长圆锥花序,和高植物时, OsMKKK10 功能的损失导致小、轻的谷物,短圆锥花序,和半矮子植物。OsMKKK10 交往与并且 phosphorylates OsMKK4。我们识别了 OsMKK4 gain-of-function 异种(large11-1D )? 那生产大、重的谷物。OsMKK4 large11-1D 等位基因编码的 A227T 比 OsMKK4 举办更强壮的 kinase 活动。植物 overexpressing OsMKK4 (OsMKK4-DD ) 的一种组成地活跃的形式也生产大谷物。进一步生物化学、基因的分析表明 OsMKKK10, OsMKK4,和 OsMAPK6 在一条普通小径工作控制谷物尺寸。一起拿,我们的学习在米饭为谷物尺寸和重量的 OsMKKK10-OsMKK4-OsMAPK6 调停串联的控制建立一个重要基因、分子的框架。 | Ran Xu Penggen Duan Haiyue Yu Zhengkui Zhou Baolan Zhang Ruci Wang Jing Li Guozheng Zhang Shangshang Zhuang Jia Lyu Na Li Tuanyao Chai Zhixi Tian Shanguo Yao Yunhai Li | 2018 | Molecular Plant2018，11，6： | 33 |
| 4 | Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro显示文摘 | Jia-lin DUAN Jing-wen WANG Yue GUAN Ying YIN Guo WEI Jia CUI Dan ZHOU Yan-rong ZHU Wei QUAN Miao-miao XI Ai-dong WEN | 2013 | Acta Pharmacologica Sinica2013，34，4： | 27 |
| 5 | Progress of Air Pollution Control in China and Its Challenges and Opportunities in the Ecological Civilization Era显示文摘China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously. | Xi Lu Shaojun Zhang Jia Xing Yunjie Wang Wenhui Chen Dian Ding Ye Wu Shuxiao Wang Lei Duan Jiming Hao | 2020 | Engineering2020，6，12： | 24 |
| 6 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 7 | Chinese guidelines on management of hepatic encephalopathy in cirrhosis显示文摘The Chinese Society of Hepatology developed the current guidelines on the management of hepatic encephalopathy in cirrhosis based on the published evidence and the panelists’ consensus. The guidelines provided recommendations for the diagnosis and management of hepatic encephalopathy (HE) including minimal hepatic encephalopathy (MHE) and overt hepatic encephalopathy, emphasizing the importance on screening MHE in patients with end-stage liver diseases. The guidelines emphasized that early identification and timely treatment are the key to improve the prognosis of HE. The principles of treatment include prompt removal of the cause, recovery of acute neuropsychiatric abnormalities to baseline status, primary prevention, and secondary prevention as soon as possible. | Xiao-Yuan Xu Hui-Guo Ding Wen-Gang Li Ji-Dong Jia Lai Wei Zhong-Ping Duan Yu-Lan Liu En-Qiang Ling-Hu Hui Zhuang | 2019 | World Journal of Gastroenterology2019，25，36： | 20 |
| 8 | Use of the Metabolomics Approach to Characterize Chinese Medicinal Material Huangqi显示文摘基因、新陈代谢的采指纹的罐头的集成提供一条新途径区分类似的繁体中文医药(TCM ) 材料。二豆科的植物, Mojia Huangqi 和 Menggu Huangqi,是在形态学,化学成分,和 genomic DNA 顺序的重要医药植物和份额伟人类似。Mojia Huangqi 和 Menggu Huangqi 的分类为超过 50years 被辩论了, TCM 材料的辨别直接影响药理学和临床的效果。AFLP 基于新陈代谢的采指纹的基因采指纹和 GCTOF/MS-based 被用来成功地区别二种。AFLP 的结果支持了 Menggu Huangqi 是 Mojia Huangqi 的变体的意见。新陈代谢的采指纹证明生长地点比遗传型在代谢物作文和数量上有更大的影响(栽培对野) 在 Menggu Huangqi。一些可溶的糖,丰满的酸,脯氨酸,和 polyamine 的差别反映了植物改编到不同生长环境。用 multivariate 和 univariate,统计分析,三个 AFLP 标记和八代谢物作为候选人 DNA 和新陈代谢的标记被识别区分二植物材料。在 AFLP 标记和代谢物之间的关联网络揭示了一个复杂关联网络,它显示了特殊新陈代谢的小径和 Huangqi 的规定网络。 | Li-Xin Duan Tian-Lu Chen Ming Li Min Chen Ye-Qing Zhou Guang-Hong Cui Ai-Hua Zhao Wei Jia Lu-Qi Huang Xiaoquan Qi | 2012 | Molecular Plant2012，5，2： | 19 |
| 9 | Effects of melatonin implantation on cashmere yield,fibre characteristics,duration of cashmere growth as well as growth and reproductive performance of Inner Mongolian cashmere goats显示文摘Background:Exogenous melatonin could induce cashmere growth.However,induced growth of cashmere fleece by melatonin implants cannot be combined with the typical growth,resulting in earlier shedding followed by another cycle of cashmere growth.To address this issue,we examine the effects on the cashmere yield,fibre characteristics,and the growth and reproductive performance of cashmere goats of planned administration of melatonin.Methods:Eighteen half-sib,female goats were assigned to two treatments(n = 9) including a control and a treatment where melatonin(2 mg/kg BW) was implanted at the end of April and end of June.Cashmere growth and shedding were observed for approximately 1 year following implantation.Fibre samples were collected monthly to determine cumulative cashmere length.Initiation and cessation dates for cashmere growth as well as the rate of cashmere growth were calculated.Cashmere yield,weight gain of dam,kidding date,litter size,and birth weight were also recorded.Results:Melatonin implantation increased cashmere yield by 34.5%(control 553.7 g vs.melatonin 745.0 g;P< 0.01),cashmere length by 21.3%(control 95.2 mm vs.melatonin 115.4 mm;P < 0.01),and decreased fibre diameter by 4.4%(control 14.6 μm vs.melatonin 14.0 μm;P < 0.03).In melatonin-treated goats,the average initiation date was earlier than in control goats(May 18,2013 vs.July 2,2013;P< 0.01) but there was a similar cessation date(March 22,2014 vs.March 27,2014).Consequently,the duration of cashmere growth was longer in melatonin-treated goats than in control goats(307 vs.270 days;P< 0.01).The final BW,average daily gain,kidding date,litter size,and birth weight were not influenced by melatonin implantation.Conclusions:These data indicate that melatonin implantation(2 mg/kg BW) on two occasions(late April and June)increased cashmere yield by combining the induced growth of cashmere fleece with the typical growth and decreased the fibre diameter without changing dam growth rate or reproductive performance. | Chunhui Duan Jianhai Xu Changmian Sun Zhihai Jia Wei Zhang | 2015 | Journal of Animal Science and Biotechnology2015，6，4： | 18 |
| 10 | Two-stage analysis of pharmacokinetics of sufentanil administered by target-controlled infusion in Chinese patients显示文摘 | ZHAO Yan DUAN Jing-li WU Xin-min JIANG Jian-yu LU Wei ZHANG Li-ping WANG Jun MENG Xiu-li XU Chuan-ya JIA Dong-lin LIU Wei SHENG Xiao-yan | 2009 | Chinese Medical Journal2009，，17： | 16 |
| 11 | High salt primes a specific activation state of macrophages, M(Na)显示文摘 | Wu-Chang Zhang Xiao-Jun Zheng Lin-Juan Du Jian-Yong Sun Zhu-Xia Shen Chaoji Shi Shuyang Sun Zhiyuan Zhang Xiao-qing Chen Mu Qin Xu Liu Jun Tao Lijun Jia Heng-yu Fan Bin Zhou Ying Yu Hao Ying Lijian Hui Xiaolong Liu Xianghua Yi Xiaojing Liu Lanjing Zhang Sheng-Zhong Duan | 2015 | Cell Research2015，25，8： | 15 |
| 12 | Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiting pericyte pyroptosis显示文摘Mesenchymal stem cell(MSC)transplantation is a promising treatment strategy for spinal cord injury,but immunological rejection and possible tumor formation limit its application.The therapeutic effects of MSCs mainly depend on their release of soluble paracrine factors.Exosomes are essential for the secretion of these paracrine effectors.Bone marrow mesenchymal stem cell-derived exosomes(BMSC-EXOs)can be substituted for BMSCs in cell transplantation.However,the underlying mechanisms remain unclear.In this study,a rat model of T10 spinal cord injury was established using the impact method.Then,30 minutes and 1 day after spinal cord injury,the rats were administered 200μL exosomes via the tail vein(200μg/mL;approximately 1×106 BMSCs).Treatment with BMSC-EXOs greatly reduced neuronal cell death,improved myelin arrangement and reduced myelin loss,increased pericyte/endothelial cell coverage on the vascular wall,decreased bloodspinal cord barrier leakage,reduced caspase 1 expression,inhibited interleukin-1βrelease,and accelerated locomotor functional recovery in rats with spinal cord injury.In the cell culture experiment,pericytes were treated with interferon-γand tumor necrosis factor-α.Then,Lipofectamine 3000 was used to deliver lipopolysaccharide into the cells,and the cells were co-incubated with adenosine triphosphate to simulate injury in vitro.Pre-treatment with BMSC-EXOs for 8 hours greatly reduced pericyte pyroptosis and increased pericyte survival rate.These findings suggest that BMSC-EXOs may protect pericytes by inhibiting pyroptosis and by improving blood-spinal cord barrier integrity,thereby promoting the survival of neurons and the extension of nerve fibers,and ultimately improving motor function in rats with spinal cord injury.All protocols were conducted with the approval of the Animal Ethics Committee of Zhengzhou University on March 16,2019. | Yan Zhou Lu-Lu Wen Yan-Fei Li Kai-Min Wu Ran-Ran Duan Yao-Bing Yao Li-Jun Jing Zhe Gong Jun-Fang Teng Yan-Jie Jia | 2022 | Neural Regeneration Research2022，17，1： | 15 |
| 13 | Combined application of virtual imaging techniques and three-dimensional computed tomographic angiography in diagnosing intracranial aneurysms显示文摘虚拟成像的诊断价值为 intracranial 动脉瘤与三维的计算 tomographic angiography (3D-CTA ) 相结合的背景还充分没被阐明。这研究试图在在尖锐阶段与动脉瘤的 subarachnoid 出血(SAH ) 诊断病人评估虚拟成像技术和 3D-CTA 的联合申请的价值。有非创伤的 SAH 的八十个病人收到了 3D-CTA 考试的方法。这些病人的未加工的 CT 数据被重建并且基于虚拟现实(VR ) 通过外科的计划系统转了进 3D 模式图象,和 3D 颅骨和大脑血容器的虚拟图象被获得。有邻近的纸巾的动脉瘤和他们的解剖关系的地点,尺寸和形状从许多观点被测量。结果 73 个动脉瘤在 80 个病人中的 68 个被检测,但是 2 个动脉瘤在以前没有动脉瘤被发现了并且一个月以后为第二次收到了 3D-CTA 考试的 5 个病人中的 2 个被检测。虚拟图象由虚拟成像系统生产了的 3D 清楚、生动,并且他们能直接揭示到父母动脉和颅骨的动脉瘤和它的关系的地点和尺寸。3D-CTA 的成像是在诊断方便、可靠、快的 intracranial 动脉瘤和罐头的结论为破裂的 intracranial 动脉瘤的诊断和治疗被认为是第一种选择。基于 VR 图象与外科的计划系统结合了, 3D-CTA 可以关于动脉瘤获得更多的成像信息。 | GUO Yan-wu KE Yi-quan ZHANG Shi-zhong WANG Qiu-jing DUAN Chuan-zhi JIA Hong-shun ZHOU Li XU Ru-xiang | 2008 | Chinese Medical Journal2008，，24： | 14 |
| 14 | Preparation and anisotropic properties of textured structural ceramics: A review显示文摘Ceramics are usually composed of randomly oriented grains and intergranular phases, so their properties are the statistical average along each direction and show isotropy corresponding to the uniform microstructures. Some methods have been developed to achieve directional grain arrangement and preferred orientation growth during ceramic preparation, and then textured ceramics with anisotropic properties are obtained. Texture microstructures give particular properties to ceramics along specific directions, which can effectively expand their application fields. In this review, typical texturing techniques suitable for ceramic materials, such as hot working, magnetic alignment, and templated grain growth(TGG), are discussed. Several typical textured structural ceramics including α-Al2O3 and related nacre bioinspired ceramics, Si3N4 and SiAlON, h-BN, MB2 matrix ultra-high temperature ceramics, MAX phases and their anisotropic properties are presented. | Zhuo ZHANG Xiaoming DUAN Baofu QIU Zhihua YANG Delong CAI Peigang HE Dechang JIA Yu ZHOU | 2019 | Journal of Advanced Ceramics2019，8，3： | 14 |
| 15 | Efficacy of Leflunomide, Telmisartan, and Clopidogrel for Immunoglobulin A Nephropathy: A Randomized Controlled Trial显示文摘 | Jie Wu Shu-Wei Duan Xue-Feng Sun Wen-Ge Li Ya-Ping Wang Wen-Hu Liu Jian-Rong Zhang Li-De Lun Xue-Mei Li Chun-Hua Zhou Ji-Jun Li Shu-Wen Liu Yuan-Sheng Xie Guang-Yan Cai Lu Ma Wen Huang Hua Wu Qiang Jia Xiang-Mei Chen | 2016 | Chinese Medical Journal2016，，16： | 13 |
| 16 | Safety,tolerability,and pharmacokinetics of VV116,an oral nucleoside analog against SARS-CoV-2,in Chinese healthy subjects显示文摘VV116(JT001)is an oral drug candidate of nucleoside analog against SARS-CoV-2.The purpose of the three phase I studies was to evaluate the safety,tolerability,and pharmacokinetics of single and multiple ascending oral doses of VV116 in healthy subjects,as well as the effect of food on the pharmacokinetics and safety of VV116.Three studies were launched sequentially:Study 1(single ascending-dose study,SAD),Study 2(multiple ascending-dose study,MAD),and Study 3(food-effect study,FE).A total of 86 healthy subjects were enrolled in the studies.VV116 tablets or placebo were administered per protocol requirements.Blood samples were collected at the scheduled time points for pharmacokinetic analysis.116-N1,the metabolite of VV116,was detected in plasma and calculated for the PK parameters.In SAD,AUC and Cmax increased in an approximately dose-proportional manner in the dose range of 25–800 mg.T_(1/2)was within 4.80–6.95 h.In MAD,the accumulation ratio for Cmax and AUC indicated a slight accumulation upon repeated dosing of VV116.In FE,the standard meal had no effect on Cmax and AUC of VV116.No serious adverse event occurred in the studies,and no subject withdrew from the studies due to adverse events.Thus,VV116 exhibited satisfactory safety and tolerability in healthy subjects,which supports the continued investigation of VV116 in patients with COVID-19. | Hong-jie Qian Yu Wang Meng-qi Zhang Yuan-chao Xie Qing-qing Wu Li-yu Liang Ye Cao Hua-qing Duan Guang-hui Tian Juan Ma Zhuo-bing Zhang Ning Li Jing-ying Jia Jing Zhang Haji Akber Aisa Jing-shan Shen Chen Yu Hua-liang Jiang Wen-hong Zhang Zhen Wang Gang-yi Liu | 2022 | Acta Pharmacologica Sinica2022，43，12： | 13 |
| 17 | Proliferation and apoptosis property of mesenchymal stem cells derived from peripheral blood under the culture conditions of hypoxia and serum deprivation显示文摘增长和间充质的干细胞的 apoptosis 性质从外部血( PB-MSCs )导出的背景在剥夺在 vitro 调节以便在软骨 repair.Methods MSC 为自体同源的 PB-MSCs 应用评估可行性的组织缺氧和浆液下面被调查被 granulocyte 殖民地刺激动员进外部血因素( G-CSF )和 AMD3100.The 血样品从 rabbits.Adhered 房间的中央耳朵动脉被收集被红血球细胞溶解 b 获得当这二个条件联合了 together.Furthermore 时,效果更强壮, apoptosis 上的浆液剥夺的效果与 hypoxia.Conclusions PB-MSCs 的相比是更强壮的当 BM-MSCs.Their 区别和增长能力在关节的软骨修理的地里为局部缺血相关的房间治疗和织物工程使他们成为种子房间的新来源,拥有类似的显型。 | FU Wei-li JIA Zhu-qing WANG Wei-ping ZHANG Ji-ying FU Xin DUAN Xiao-ning LEUNG Kevin Kar Ming ZHOU Chun-yan YU Jia-kuo | 2011 | Chinese Medical Journal2011，，23： | 11 |
| 18 | Progress of a novel non-oxide Si-B-C-N ceramic and its matrix composites显示文摘In the past twenty years,Si-B-C-N ceramic has attracted wide attention due to its special structure and outstanding properties.The ceramic generally has an amorphous or a nano-crystalline structure,and has excellent structural stability,oxidation resistance,creep resistance and high-temperature mechanical properties,etc.Thus,Si-B-C-N ceramic attracts many researchers and finds potential applications in transportation,aerocraft,energy,information,microelectronics and environment,etc.Much work has been carried out on its raw materials,preparation processes,structural evolution,phase equilibrium and high-temperature properties.In recent years,many researchers focus on its new preparation methods,the preparation of dense ceramic sample with large dimensions,ceramic matrix composites reinforced by carbon fiber or SiC whisker,or components with various applications.Research on Si-B-C-N ceramic will develop our insight into the relationship between structures and properties of ceramics,and will be helpful to the development of novel high-performance ceramics.This paper reviews the preparation processes,general microstructures,mechanical,chemical,electrical and optical properties,and potential applications of Si-B-C-N ceramic,as well as its matrix composites. | Pengfei ZHANG Dechang JIA Zhihua YANG Xiaoming DUAN Yu ZHOU | 2012 | Journal of Advanced Ceramics2012，1，3： | 11 |
| 19 | Treatment of hyperbilirubinemia with blood purification in China显示文摘The incidence of hyperbilirubinemia is high clinically, which is difficult to cure by medication, surgery or interventional therapies. Non-bioartificial liver is the main alternative in the blood purification for hyperbilirubinemia, which includes plasma exchange, hemoperfusion, hemodialysis, molecular adsorbent recycling system and so on. The research results and clinical experiences in China show that these methods are effective in lowering high levels of bilirubin with fewer side effects. The hyperbilirubinemias of different causes, with different complications or accompanying different diseases can be treated by different methods. Bioartificial liver, hybrid artificial liver support system and adsorbent membrane material have also been studied and their development in reducing hyperbilirubinemias has been achieved. This article gives a brief overview on the actuality and research improvement in blood purification for hyperbilirubinemia in China. | Zhi-Jun Duan Lei-Lei Li Jia Ju Zhi-Hong Gao Gao-Hong He | 2006 | World Journal of Gastroenterology2006，12，46： | 10 |
| 20 | Milling surface roughness for 7050 aluminum alloy cavity influenced by nozzle position of nanofluid minimum quantity lubrication显示文摘In nanofluid minimum quantity lubrication(NMQL)milling of aviation aluminum alloy,it is the bottleneck problem to adjust the position parameters(target distance,incidence angle,and elevation angle)of the nozzle to improve the surface roughness of milling,which has large and uncontrollable errors.In this paper,the influence law of milling cutter speed,helical angle,and cavity shape on the flow field around the milling cutter was studied,and the optimal nozzle profile parameters were obtained.Using 7050 aluminum alloy as the workpiece material,the milling experiment of the NMQL cavity was conducted by utilizing cottonseed oil-based Al2 O3 nanofluid.Results show that the high velocity of the surrounding air flow field and the strong gas barrier could be attributed to high rotating velocities of the milling cutter.The incidence angle of the nozzle was consistent with the helical angle of the milling cutter,the target distance was appropriate at 25–30 mm,and the elevation angle was suitable at 60°–65°.The range and variance analyses of the signal-to-noise ratio of milling force and roughness were performed,and the chip morphology was observed and analyzed.The results show that the optimal combination of nozzle position parameters was the target distance of 30 mm,the incidence angle of 35°,and the elevation angle of 60°.Among these parameters,target distance had the largest impact on cutting performance with a contribution rate of more than 55%,followed by incidence angle and elevation contribution rate.Analysis by orthogonal experiment revealed that the nozzle position parameters were appropriate,and Ra(0.087 lm)was reduced by 30.4%from the maximum value(0.125 lm).Moreover,Rsm(0.05 mm)was minimum,which was 36%lower than that of the seventh group(Rsm=0.078 mm). | Zhenjing DUAN Changhe LI Yanbin ZHANG Lan DONG Xiufang BAI Min YANG Dongzhou JIA Runze LI Huajun CAO Xuefeng XU | 2021 | Chinese Journal of Aeronautics2021，34，6： | 10 |
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