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| 1 | Role of receptor tyrosine kinases in gastric cancer: New targets for a selective therapy显示文摘受体酷氨酸家族 ases (RTK ) 象表皮的生长因素受体家庭那样包括增长和变形传播参予肿瘤形成的几步。几已知的 RTK 起来在是主要的胃的癌症调整了定制的治疗的目标。仅仅初步的数据然而,在使用上存在当前临床上可得到的药象在胃的癌症的背景的 trastuzumab, cetuximab, bevacizumab, gefitinib, erlotinib,和 imatinib 那样。现出症状之前的潜的数据建议他们的使用的一个潜在的好处,特别在有“常规”的抑制细胞的联合治疗。这评论象新途径和药一样在癌症治疗关于他们的使用总结当前的知识优化治疗成功。 | JC Becker C Müller-Tidow H Serve W Domschke T Pohle | 2006 | World Journal of Gastroenterology2006，12，21： | 19 |
| 2 | Schedule synchronization for public tran- sit networks显示文摘 | Domschke W | 1989 | Operations-Research-Spektrum1989，11，1： | 1 |
| 3 | Self-explanding mesh stent for esophageal cancer stenosis显示文摘 | Domschke W Foerster EC Matek W | 1990 | Endoscopy1990，22，： | 1 |
| 4 | Motilin-a new human gut hormone显示文摘 | Mitznegg D Domschke W | 1977 | Acta Heoate-Gastroent1977，24，： | 1 |
| 5 | Muhiple center capacitated arc routing problems:a tabu search algorithm using capacitated trees显示文摘 | Domschke A A W VoB S | 2000 | European Journal of Operational Research2000，124，： | 1 |
| 6 | Intraductal ultrasonography may localize islet cell tumours negative on endoscopic ultrasound显示文摘 | Domschke W | 1998 | Scand J Gastroenterol1998，33，1： | 1 |
| 7 | Self-expanding mesh stent for esophageal cancer stenosis 显示文摘 | Domschke W Foerster EC Matek W | 1992 | Endoscopy1992，22，1： | 1 |
| 8 | Arterioportal fistula: a rare cause of portal hypertension and abdominal pain 显示文摘 | Pohle T Fischbach R Domschke W | 2001 | Scand J Gastroenterol2001，36，11： | 1 |
| 9 | Silicone breast implants:correlation between implant ruptures,magnetic resonance spectroscopically estimated silicone presence in the liver,antibody status and clinical symptoms显示文摘 | Gaubitz M Jackisch C Domschke W | 2002 | Rheumatology (Oxford)2002，41，2： | 1 |
| 10 | Reduced expression of Ca^(2+)-regulating proteins in the upper gastrointestinal tract of patients with achalasia显示文摘AIM: To compare expression of Ca2+-regulating proteins in upper gastrointestinal (GI) tract of achalasia patients and healthy volunteers and to elucidate their role in achalasia. METHODS: Sarcoplasmic reticulum Ca2+ ATPase (SERCA) isoforms 2a and 2b, phospholamban (PLB), calsequestrin (CSQ), and calreticulin (CRT) were assessed by quantitative Western blotting in esophagus and heart of rats, rabbits, and humans. Furthermore, expression profi les of these proteins in biopsies of lower esophageal sphincter and esophagus from patients with achalasia and healthy volunteers were analyzed. RESULTS: SERCA 2a protein expression was much higher in human heart (cardiac ventricle) compared to esophagus. However, SERCA 2b was expressed predominantly in the esophagus. The highest CRT expression was noted in the human esophagus, while PLB, although highly expressed in the heart, was below our detection limit in upper GI tissue. Compared to healthy controls, CSQ and CRT expression in lower esophageal sphincter and distal esophageal body were signif icantly reduced in patients with achalasia (P < 0.05). CONCLUSION: PLB in the human esophagus mightbe of lesser importance for regulation of SERCA than in heart. Lower expression of Ca2+ storage proteins (CSQ and CRT) might contribute to increased lower esophageal sphincter pressure in achalasia, possibly by increasing free intracellular Ca2+. | Harald Fischer Judith Fischer Peter Boknik Ulrich Gergs Wilhelm Schmitz Wolfram Domschke Jan W Konturek Joachim Neumann | 2006 | World Journal of Gastroenterology2006，12，37： | 1 |
| 11 | Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cell monolayers 显示文摘 | Mooren FC Berthold A Domschke W | 1998 | Phuarm Res1998，15，1： | 1 |
| 12 | Influence of chitosan microspheres on the transport of prednisolone sodium phosphate across HT-29 cellmonolayers显示文摘 | Mooren F C Berthold A Domschke W | 1998 | Pharm Res1998，15，1： | 1 |
| 13 | a-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling显示文摘 | Bantel H Sinha B Domschke W | 2001 | J Cell Bio12001，4，155： | 1 |
| 14 | α-Toxin is a mediator of Staphylococcus aureus-induced cell death and activates caspases via the intrinsic pathway independently of death receptor signaling显示文摘 | Bantel H Sinha B Domschke W | 2001 | J Cell Biol2001，155，： | 1 |
| 15 | Role of lymphotoxins in the development of Peyer's patches andmesenteric lymph nodes :relevance to intestinal inflamma- tion and treatment 显示文摘 | Spahn TW Maller MK Domschke W | 2006 | Ann N Y Acad Sci2006，1072，： | 1 |
| 16 | Reoperative diagnosis of bile duct strictures-comparison of intraductal ultrasonography with conventional endosonography显示文摘 | Menzel J Poremba C Dietl KH Domschke W | 2000 | Scand J Gastroenterol2000，35，1： | 1 |
| 17 | STATS: A Sl- icing Tree and Tabu Search Based Heuristic for the Unequal Area Facility Layout Problem 显示文摘 | Scholz D Petrick A Domschke W | 2009 | European Journal of Operational Research2009，197，1： | 1 |
| 18 | Intraduct alultrasonography may local-ize isletcelltumors negativ eonendoscopic ultrasound scand显示文摘 | Menzel J Domschke W | 1998 | J Gastroenterol1998，33，1： | 1 |
| 19 | The job shop scheduling problem: conventional and new solution techniques显示文摘 | Blazewicz J Domschke W Pesch E | 1996 | Europe Journal of Production Research1996，93，1： | 1 |
| 20 | Longer relapse freeperiod after sucralfate than after H2-bloker treatmentof duodenal and gastric ulcers显示文摘 | DOMSCHKE S DOMSHKE W | 1991 | Am J Med1991，91，2： | 1 |
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