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| 1 | From regenerative strategies to pharmacological approaches:can we fine-tune treatment for Parkinson's disease?显示文摘Parkinson's disease is the second most prevalent neurodegenerative disorder worldwide.Clinically,it is characterized by severe motor complications caused by progressive degeneration of dopaminergic neurons.Current treatment is focused on mitigating the symptoms through the administration of levodopa,rather than on preventing dopaminergic neuronal damage.Therefore,the use and development of neuroprotective/disease-modifying strategies is an absolute need that can lead to promising gains on translational research of Parkinson's disease.For instance,N-acetylcysteine,a natural compound with strong antioxidant effects,has been shown to modulate oxidative stress,preventing dopamine-induced cell death.Despite the evidence of neuroprotective and modulatory effects of this drug,as far as we know,it does not induce per se any regenerative process.Therefore,it would be of interest to combine the latter with innovative therapies that induce dopaminergic neurons repair or even differentiation,as stem cell-based strategies.Stem cells secretome has been proposed as a promising therapeutic approach for Parkinson's disease,given its ability to modulate cell viability/preservation of dopaminergic neurons.Such approach represents a shift in the paradigm,showing that cell-transplantation free therapies based on the use of stem cells secretome may represent a potential alternative for regenerative medicine of Parkinson's disease.Thus,in this review,we address the current understanding of the potential combination of stem cell free-based strategies and neuroprotective/disease-modifying strategies as a new paradigm for the treatment of central nervous system neurodegenerative diseases,like Parkinson's disease. | Rita Caridade Silva Helena Sofia Domingues António J.Salgado Fábio G.Teixeira | 2022 | Neural Regeneration Research2022，17，5： | 2 |
| 2 | Microstructural and mechanical study of zirconia hydroxyapatite composite ceramics for biomedical applications 显示文摘 | Silva V V Lameiras F S Domingues R Z | 2001 | Compos Sci Technol2001，61，2： | 1 |
| 3 | The RNA reeognition mo- tif, a plastic RNA-binding platform to regulate post-transcription- al gene expression显示文摘 | Maris C Domingue Z C Allain F H | 2005 | FEBS J2005，272，9： | 1 |
| 4 | The influence of cul-ture conditions on mycelial structure and eellulase production by Trichoderma reese/Rut C-30显示文摘 | Domingues F C Queiroz J A Cabral J M S | 2000 | Enzyme and Microbial Technolo-gy2000，26，5： | 1 |
| 5 | Arabinosyl and glucosyl residues as structural features of acetylated galactomannans from green and roasted coffee infusions 显示文摘 | Nunes F M Domingues M R Coimbra M A | 2005 | Carbohydrate Research2005，，10： | 1 |
| 6 | Structuralcharacterization of the lignin from the nodes and intemodes ofArundo donaxreed 显示文摘 | Seca A M L Cavaleiro J A S Domingues F M J | 2000 | J Agric Food Chem2000，48，： | 1 |
| 7 | Subarachnoid hem-orrhage in isolated cortical vein thrombosis:are presentation of an unu-sual condition显示文摘 | Bittencourt LK Palma-Filho F Domingues RC | 2009 | Arq Neuropsiquiatr2009，67，： | 1 |
| 8 | Detection of Toxoplasma gondii in swine sausages显示文摘 | Mendonca A D O Domingues P F Silva A V D | 2004 | Parasitol Latinoam2004，59，： | 1 |
| 9 | Structural characterization of the lignin from the nodes and internodes of Arundo donax reed显示文摘 | Seca A M Cavaleiro J A Domingues F M | 2000 | Journal of Agricultural&Food Chemistry2000，48，3： | 1 |
| 10 | Detection of Toxoplasma gondii in swine sausages 显示文摘 | Mendonca A D O Domingues P F Silva A V D | 2004 | Parasitol Latinoam2004，，59： | 1 |
| 11 | Mycoplasmas:what is the role in human infections显示文摘 | Domingues D Nogueira F Tavira L | 2005 | Acta Med Port2005，18，5： | 1 |
| 12 | Cervical spondylotic myelopathy: 10 years of prospective outcome analysis of anterior decompression and fusion显示文摘 | Chagas H Domingues F Aversa A | 2005 | Surg Neurol2005，64，1： | 1 |
| 13 | Diffusion tensor MR imaging evaluation of the corpus callosum of patients with multiple sclerosis显示文摘 | Rueda F Hygino LC Jr Domingues RC | 2008 | Arq Neuropsiquiatr2008，66，3： | 1 |
| 14 | WILMA-automated Annotation of Protein Sequences显示文摘 | Prlic A Domingues F S Lackner P | 2004 | Bioinformatics2004，20，1： | 1 |
| 15 | Cervical spondylotic myelopathy: 10 years of prospective outcome analysis of anteriordecompression and fusion显示文摘 | Chagas H Domingues F Aversa A | 2005 | Surg Neurol2005，641，： | 1 |
| 16 | Neoadjuvant chemotherapy in advanced vulvar cancer 显示文摘 | Domingues AP Mota F Durao M | 2010 | Int J Gynecol Cancer2010，20，2： | 1 |
| 17 | Uranium determination at ppb levels by X-ray fluorescence after its preconcentration on polyurethane foam显示文摘 | Carvalho M S Domingues M D F Mantovano J L | 1998 | Spectrochim Acta Part B: At Spectro1998，53，14： | 1 |
| 18 | The stable carbon and nitrogen isotopic composition of vegetation in tropical forests of the Amazon Basin, Brazil显示文摘 | Ometto J P H B Ehleringer J R Domingues T F | 2006 | Bigeochemistry2006，79，： | 1 |
| 19 | Cervical spondylotic myelopathy:10 years of prospective outcome analysis of anterior decompression and fusion显示文摘 | Domingues F Aversa A | 2005 | Surg Neurol2005，64，1： | 1 |
| 20 | Composites Sci Tech显示文摘 | Silva V V Lameiras F S Domingues R Z | 2001 | 61:3012001，61，： | 1 |
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