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| 1 | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis显示文摘AIM: To investigate whether serum levels of two soluble forms of extracellular cytokeratin 18 (M30-antigen and M65-antigen) may differentiate nonalcoholic steatohepatitis (NASH) from simple steatosis in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 83 patients with suspected NAFLD and 49 healthy volunteers were investigated. Patients with suspected NAFLD were classified according to their liver histology into four groups: definitive NASH (n = 45), borderline NASH (n = 24), simple fatty liver (n = 9), and normal tissue (n = 5). Serum levels of caspase-3 generated cytokeratin-18 fragments (M30-antigen) and total cytokeratin-18 (M65-antigen) were determined by ELISA. RESULTS: Levels of M30-antigen and M65-antigen were significantly higher in patients with definitive NASH compared to the other groups. An abnormal value (> 121.60 IU/L) of M30-antigen yielded a 60.0% sensitivity and a 97.4% specificity for the diagnosis of NASH. Sensitivity and specificity of an abnormal M65-antigen level (> 243.82 IU/L) for the diagnosis of NASH were 68.9% and 81.6%, respectively. Among patients with NAFLD, M30-antigen and M65-antigen levels distinguished between advanced fibrosis and early-stage fibrosis with a sensitivity of 64.7% and 70.6%, and a specificity of 77.3% and 71.2%, respectively. CONCLUSION: Serum levels of M30-antigen and M65-antigen may be of clinical usefulness to identify patients with NASH. Further studies are mandatory to better assess the role of these apoptonecrotic biomarkers in NAFLD pathophysiology. | Yusuf Yilmaz Enver Dolar Engin Ulukaya Semra Akgoz Murat Keskin Murat Kiyici Sibel Aker Arzu Yilmaztepe Selim Gurel Macit Gulten Selim Giray Nak | 2007 | World Journal of Gastroenterology2007，13，6： | 19 |
| 2 | Evaluation of leukocyte esterase and nitrite strip tests to detect spontaneous bacterial peritonitis in cirrhotic patients显示文摘AIM: To investigate the diagnostic eff icacy of leukocyte esterase and nitrite reagent strips for bedside diagnosis of spontaneous bacterial peritonitis (SBP). METHODS: A total of 63 consecutive patients with cirrhotic ascites (38 male, 25 female) tested between April 2005 and July 2006 were included in the study. Bedside reagent strip testing was performed on ascitic ? uid and the results compared to manual cell counting and ascitic fluid culture. SBP was defined as having a polymorphonuclear ascites count of ≥ 250/mm3. RESULTS: Fifteen samples showed SBP. The sensitivity, specificity, positive and negative predictive values of the leukocyte esterase reagent strips were; 93%, 100%, 100%, and 98%, respectively. The sensitivity, specifi city, positive and negative predictive value of the nitrite reagent strips were 13%, 93%, 40%, and 77%, respectively. The combination of leukocyte esterase and nitrite reagents strips did not yield statistically signif icant effects on diagnostic accuracy. CONCLUSION: Leukocyte esterase reagent strips may provide a rapid, bedside diagnostic test for SBP. | Serkan Torun Enver Dolar Yusuf Yilmaz Murat Keskin Murat Kiyici Melda Sinirtas Emre Sarandol Selim Gurel Selim Giray Nak Macit Gulten | 2007 | World Journal of Gastroenterology2007，13，45： | 8 |
| 3 | Effect of water matrices on removal of veterinary pharmaceuticals by nanofiltration and reverse osmosis membranes显示文摘This study explored the removal of five veterinary pharmaceuticals (VPs) (sulfamethoxazole (SMETOX), trimethoprim (TMP), ciprofloxacin (CIPRO), dexamethasone (DEXA) and febantel (FEBA)) from different water matrices (Milli-Q water, model water, tap water and real pharmaceutical wastewater using four types of nanofiltration (NF) membranes (NF90, NF270, NF and HL) and two reverse osmosis (RO) membranes (LFC-1 and XLE). All VPs were added to different water matrices at a concentration of 10 mg/L. Rejections of VPs and water flux were measured. The rejection increased with increase of molecular weight. The highest rejections were obtained with RO membranes (LFC-1, XLE) and tight NF (NF90) membrane. In general, the rejection of VPs was higher in model water and tap water than in Milli-Q water, but the water flux was lower. This was mainly explained by ion adsorption inside the membranes pores. Narrower pore size counteracted the effect of presence of low concentration of natural organic matter (NOM) in tap water. The NOM was assumed to enhance the adsorption of VPs onto membrane surface, increased the size exclusion and electrostatic repulsion also appeared during the transport. Investigated water matrices had influence on water flux decline due to their complexity. | Davor Dolar Ana Vukovi Danijela Aperger Kreimir Kouti | 2011 | Journal of Environmental Sciences2011，23，8： | 4 |
| 4 | Peritoneal tuberculosis with pelvic abdominal mass,ascites and elevated CA 125 mimicking advanced ovarian carcinoma:a series of 10 cases显示文摘 | Bilgin T Karabay A Dolar E | 2001 | Int J Gynecol Cancer2001，11，： | 1 |
| 5 | The relationship between cerbB-2 oncogene expression and clinicopathological factors in gastric cancer显示文摘 | Gurel S Dolar E Yerci O | 1999 | J Int Med Res1999，27，2： | 1 |
| 6 | Peritoneal tuberculosis with pelvic abdominal mass,ascites and elevated CA125 mimicking advanced ovarian carcinoma:a series of 10 cases显示文摘 | Bilgin T Karabay A Dolar E | 2002 | Int J Gynecol Cancer2002，11，4： | 1 |
| 7 | Development and optimization of the SPE procedure for determination of pharma- ceuticals in water samples by HPLC-diode array detection 显示文摘 | PAVLOVIC D M BABIC S DOLAR D | 2010 | Journal of Seperation Science2010，33，： | 1 |
| 8 | Expression of P53 protein and prognosis in gastric carcinoma显示文摘 | Gurel S Dolar E Yerci O | 1999 | J Int Med Res1999，27，2： | 1 |
| 9 | The relationshipe of c-erbB-2 oncogene expression and clinicopathologic factors in gastric cancer显示文摘 | Durel S Dolar E Yerci O | 1999 | J Int Meal Res1999，27，2： | 1 |
| 10 | 显示文摘 | St Onge L M Dolar E Anglim M A | 1979 | Clin Chem1979，25，： | 1 |
| 11 | Peritoneal tuberculosis with pelvic abdominal mase, ascites and elevated CA125 mimicking ad- vanced ovarian carcinoma: a aeries of 10 cases 显示文摘 | Bilgin T Karabay A Dolar E | 2001 | Int J Gynecol- Cancer2001，11，4： | 1 |
| 12 | Removal of an- tibioties from a model wastewater by RO/NF membranes 显示文摘 | KOSUTIC K DOLAR D ASPERGER D | 2007 | Separation and Purification Technology2007，53，3： | 1 |
| 13 | Photolysis of enrofloxaein and removal of its photodegradation products from water by reverse osmosis and nanofihration membranes显示文摘 | DOLAR D KOSUTIC K PERISA M | 2013 | Separation and Purification Technology2013，115，： | 1 |
| 14 | 显示文摘 | Baysal C Dalva K | 1993 | Eur J Gastroenterol Hepatol1993，5，： | 1 |
| 15 | Removal of emerging contaminants from municipal wastewater with an integrated membrane system, MBR-RO 显示文摘 | Dolar D Gros M Rodriguez-Mozaz S | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 16 | Removal of antibi- otics from a model wastewater by RO/NF membranes 显示文摘 | Kosutic K Dolar D Asperger D | 2007 | Separation and purification technology2007，53，： | 1 |
| 17 | Pefitoneal tuberculosis with pelvic abdominal mase,ascites and elevated CA125 mimicking advanced ovarian carcinoma: a aeries of 10 cases 显示文摘 | Bilgin T Karabay A Dolar E | 2001 | Int J Gynecol Cancer2001，11，4： | 1 |
| 18 | The use of continuous atropine infusion in the management of severe tetanus 显示文摘 | Dolar D | 1992 | Intensive Care Med1992，18，1： | 1 |
| 19 | 显示文摘 | St Onge L M Dolar E Anglirn M A | 1979 | Clin Chem1979，，25： | 1 |
| 20 | Removal of antibiotics from a model wastewater by RO/NF membranes显示文摘 | Kosutic K Dolar D Asperger D | 2007 | Separation and Purification Technology2007，53，3： | 1 |
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