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| 1 | 中文版Mishel疾病不确定感量表的重新修订及其在中国恶性肿瘤患者中的信效度检验显示文摘目的重新翻译、修订中文版Mishel疾病不确定感量表(MUIS),并测试其在中国恶性肿瘤患者中的信效度。方法将原MUIS汉化并对其进行修订,形成中文版MUIS。采用便利抽样法选取2015年7月—2016年4月在广州中医药大学第一附属医院、中山大学肿瘤防治中心、广东省中医院接受治疗的恶性肿瘤患者550例为调查对象。采用一般资料表、中文版MUIS、焦虑自评量表(SAS)、抑郁自评量表(SDS)、中文版癌症自我管理效能感量表(SUPPH)对其进行调查。2周后,采用EXCEL自带的随机程序从470例患者中选取50例,采用中文版MUIS对其进行重测。对中文版MUIS进行条目分析、信效度分析,并确定其截断值。结果中文版MUIS包括模糊、缺乏澄清、不可预测3个维度,共20个条目。中文版MUIS各条目的内容效度指数(CVI)为0.73~1.00;KMO值为0.810,Bartlett's球形检验χ2=871.55,P<0.001。3因子模型能在满足各项因子提取标准的前提下最大限度地解释方差(57.23%);模型的拟合指标分别为RMSEA=0.037、CFI=0.905、GFI=0.936、AGFI=0.911、SRMR=0.052。中文版MUIS总分及其各维度得分与SAS得分、SDS得分均呈正相关,与SUPPH总分及其各维度得分均呈负相关(P<0.05)。中文版MUIS的Cronbach'sα系数为0.825,重测信度系数为0.836;MUIS截断值为60.5分,灵敏度为0.715,特异度为0.759。结论中文版MUIS具有良好的信效度,更适合中国恶性肿瘤患者使用,同时可作为恶性肿瘤患者高危心理的初步筛查工具。 | 叶增杰 佘颖 梁木子 Knobf Tish Dixon Jane 胡蕖 曾珍 胡光云 朱云飞 邱鸿钟 | 2018 | 中国全科医学2018，21，9： | 159 |
| 2 | 中文版10条目心理韧性量表在恶性肿瘤患者中的应用研究显示文摘目的探讨中文版10条目心理韧性量表(CD-RISC-10)在恶性肿瘤患者中的信效度。方法采用便利抽样法选取2015年12月—2016年7月于广州中医药大学第一附属医院、中山大学肿瘤防治中心、广东省中医院接受治疗的恶性肿瘤患者520例为调查对象,采用一般资料表、中文版CD-RISC-10、医院焦虑抑郁量表(HADS)、癌症患者自我管理效能感量表(SUPPH)对其进行调查。共发放问卷520份,回收有效问卷424份,有效回收率为81.5%。大样本施测2周后,采用EXCEL软件自带的随机程序从424例患者中选取50例采用中文版CD-RISC-10对其进行重测。采用双参数项目反应模型对中文版CD-RISC-10进行单维性检验、等级反应模型(GRM)条目分析,并分析其聚合效度、重测信度及截断值。结果中文版CD-RISC-10仍保持单维结构,共解释58.06%的变异量,整个量表条目分离指数(ISI)为0.914。10个条目难度分布均匀,区分度为1.17~1.82,残差拟合度为-2.5~2.5,阈值间距为1.08~3.17 logits,不存在阈值倒错的情况。中文版CD-RISC-10得分与HADS总分及其焦虑、抑郁得分呈负相关,与SUPPH总分及其各维度得分呈正相关(P<0.05)。中文版CD-RISC-10的重测信度系数为0.855,截断值为21.5分,灵敏度为0.735,特异度为0.833。结论中文版CD-RISC-10的单维性、单调性良好,条目的难度、阈值间距分布合理,同时具有较高的信度和外标效度,对于筛查情绪困扰的恶性肿瘤患者具有较高的敏感性,建议临床使用。 | 叶增杰 王桢钰 梁木子 Knobf Tish Dixon Jane 佘颖 胡蕖 曾珍 胡光云 朱云飞 邱鸿钟 | 2018 | 中国全科医学2018，21，15： | 43 |
| 3 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 4 | Hepatitis B virus x gene and cyanobacterial toxins promote aflatoxin B_1-induced hepatotumorigenesis in mice显示文摘瞄准:估计黄麴毒素的结合的角色 B1 (AFB1 ) , cyanobacterial 毒素(cyanotoxins ) ,和肝炎 B (HBV ) 在 hepatotumorigenicity 的 x 基因。方法:( ip )带 HBV x 基因和他们的野类型的同窝出生的人的 One-week-old 动物 intraperitoneally 与也被注射单个剂量的 AFB1 [ 6 mg/kg 体重( bw )],重复剂量 cyanotoxins ( microcystin-LR 或在榴状, 10 microg/kg bw 每周一次为 15 wk ), DMSO (车辆控制)独自一个,或 AFB1 一个星期以后由 cyanotoxins 列在后面,并且在 24 和 52 wk 被牺牲处理以后。结果:AFB1 在 29 中的 13 个导致了肝肿瘤(44.8%) 在 52 wk 的转基因的老鼠处理以后,显著地比在野类型的老鼠(13.3%) 更经常。这有效差量没在 24-wk 学习被显示出。与 AFB1 暴露相比独自一个, MC-LR 并且在榴状在导致的 AFB (1 ) 的发生产出近似 3 褶层和 6 褶层增加在在 24 wk 的野类型的动物的肝肿瘤分别地。HBV x 基因进一步没提高与合作暴露联系到 AFB1 和 cyanotoxins 的风险。与一个 MC-LR-dosed 野类型的鼠标的异常,没有肝肿瘤在在 24 wk 独自与 cyanotoxins 对待的鼠标被观察。既不对待 DMSO 的转基因的老鼠也不他们的野类型的同窝出生的人在甚至多达 52 wk 有与 hepatotumorigenesis 相关的病理学的改变。结论:HBV x 基因并且在榴状支持导致的 AFB (1 ) 的发展肝肿瘤。到 AFB1 和 MC-LR 的合作暴露趋于相对暴露在 24 wk 提高肝肿瘤的风险到他们之一。hepatotumorigenesis 上的 AFB1, cyanotoxins 和 HBVx 的结合的效果在 24 wk 是弱的。 | Min Lian Ying Liu Shun-Zhang Yu Geng-Sun Qian Shu-Guang Wan Kenneth R Dixon | 2006 | World Journal of Gastroenterology2006，12，19： | 14 |
| 5 | 中国西部电网电击猛禽致死事故调查显示文摘2004~2008年调查了西部电网电击猛禽情况。调查区域包括新疆、青海、四川、甘肃、西藏等省区。共统计10 kV和35 kV输电线路长度178 km、杆塔数1 800余根;收集线路附近鸟的尸体、羽毛、残骸等110件,用于鉴定鸟种。调查结果,被电死猛禽计79只(10 kV),平均每千米输电线路1.36只,11.31%的杆塔对鸟类构成威胁;35 kV输电线路上鸟巢数44个,平均每千米输电线路0.37个,至少6.06%杆塔被猛禽利用。已知24%~40%的跳闸停电事故是由于鸟类引发的。症结分析,西部电网结构设计不合理,线路裸露,缺乏防鸟措施。在西部约20%左右的猛禽(11种)受到电击的威胁,同时严重影响着输电线路安全运行。本文提出了合理化建议。 | 梅宇 马鸣 Andrew Dixon 胡宝文 | 2008 | 动物学杂志2008，43，4： | 11 |
| 6 | 中国西部地区猎隼(Falco cherrug)繁殖生物学与保护显示文摘自2001—2006年,中国科学院与英国鸟类研究中心联合对新疆准噶尔盆地和昆仑山、青海玉树地区、西藏那曲地区的猎隼(Falco cherrug)分布状况与繁殖生态进行深入调查。考察行程上万公里。卫星跟踪显示在俄罗斯、蒙古繁殖的猎隼迁往青藏高原越冬。但是,实地调查表明,在新-青-藏还有一些繁殖种群;繁殖区的海拔高度从600m,上升至5200m。根据观察,猎隼喜欢沿用旧巢,多数巢属于“垃圾巢”。因为高原缺乏合适的巢材,那些人类遗弃的皮管、铁丝、皮带、破布、汽车零件、骨片、绳子等垃圾充斥于巢穴之中。考察期间,共找到100多只猎隼成鸟、约35个猎隼巢或巢区;分布地点涉及昆仑山脉、准噶尔盆地、卡拉麦里山脉、北塔山、可可西里、唐古拉山脉等,包括新疆奇台、且末、青河、塔城,青海楚玛尔河、五道梁、曲麻菜、雁石坪、玉树,西藏安多、那曲等。猎隼巢址多位于悬崖凹陷处(21个)、河岸砂土洞(5)、桥梁(2)等处;巢高于地面7—30m。通常沿用渡鸦、大鸳、棕尾鸳、金雕的旧巢,有同步繁殖现象。附近有鼠兔、雪雀、地鸦、岩鸽、石鸡、沙鸡等活动。巢区沿着山脉或者丘陵连续分布,巢间距最近2.5km,通常4—8km或更远。在准噶尔盆地其繁殖密度1.1~1.6对/1000km^2。通常4—5月产卵,窝卵数3—5枚;5月上旬和中旬已有部分幼乌出壳。虽然在中国捕捉猎隼现象十分猖獗,但考察结果依然令人振奋。建议中国猎隼研究小组(CSRG)积极开展国际合作,通过卫星跟踪、GPS定位、电子微芯片标记(PIT)、DNA指纹图谱分析、人工猎隼栖架和巢穴招引技术等,不断完善监测手段和管理机制,为猎隼的保护与合理利用做出努力。 | 马鸣 梅宇 Eugene Potapov 吴逸群 Andrew Dixon Dimitar Ragyov 徐峰 Nicholas C.Fox | 2007 | 干旱区地理2007，30，5： | 9 |
| 7 | 土壤中粘粒的作用显示文摘粘粒是土壤具有许多物理、化学性质的根源,这些性质使土壤能成为作物生长的良好场所及废物处置介质。土壤中的粘粒矿物与天然矿物相比有其特殊性。粘粒的阳离子交换性能为土壤能吸持植物养分离子最重要的性质之一,其离子吸附选择性在土壤作为生长作物和处置废物介质中有一定作用。土壤层状硅酸盐中的原生态K是伊利和云母提供作物生长的主要元素。粘粒的分散和絮凝是影响土壤结构、脆性等性质的重要因素。蛭石和蒙皂石的阳离子交换位通常存在Al^(3+)或聚合Al。氧化铁与土壤的颜色、团聚作用、吸附性能有关。氧化锰与微量元素的吸持及Fe的氧化有关。锂硬锰矿是土壤中的另一类矿物。 | J. B. Dixon 朱永宫 | 1992 | 土壤学进展1992，20，3： | 9 |
| 8 | Characterization of the Formation of Branched Short-Chain Fatty Acid:CoAs for Bitter Acid Biosynthesis in Hop Glandular Trichomes显示文摘痛苦的酸,作为啤酒香料并且为他们的多样的生物活动为他们的使用知道,主要 formedin 跳跃(Humulus lupulus ) 腺的毛状体。分叉的短链的 acyl-CoAs (例如 isobutyryl-CoA, isovaleryl-CoA 和 2-methylbutyryl-CoA ) , derivedfrom 分支链氨基酸(BCAA ) 的降级,为痛苦的 acidsin 的生合成的必要积木跳跃。然而,很少关于部件被需要生产并且维持分叉的 short-chainacyl-CoAs 的水池在的被知道跳跃毛状体。这里,我们在场 CoA ligases 和 thioesterases 是在痛苦的酸生合成的 likelyinvolved 的证据的几根线。蛋白质有的 Recombinant HlCCL2 ( carboxyl CoA ligase )为象底层酸的 isovaleric 的高特定的活动( K 猫 /K m = 4100 s 1 M 1),而 recombinant HlCCL4 明确地利用了 isobutyric 酸( K 猫 /K m = 1800 s 1 M 1)并且 2-methylbutyric 酸( K 猫 /K m = 6900 s 1 M 1)作为底层。两 HlCCLs 跳跃 valerophenone synthase (HlVPS ) ,在腺的毛状体强烈被表示并且对细胞质局部性。有在酵母的 HlVPS 的 HlCCL2 和 HlCCL4 的合作表示导致了 acylphloroglucinols (为痛苦的酸生合成的直接先锋) 的重要生产, whichfurther 在 vivo 证实了这二 HlCCLs 的生物化学的功能。在线粒体催化 CCL 的反向的反应的 thioesterase 的功能的鉴定,和 thecomprehensive,基因的分析包含了 BCAA 分解代谢,支持了 cytosolic CoA ligases 在腺的毛状体为 linkingBCAA 降级和痛苦的酸生合成被要求的想法。进化和另外的可能的生理的 rolesof 分叉短链的丰满的酸: 在 planta 的 CoA ligases 也是 discussed.Key 词: | Haiyang Xu Fengxia Zhang Baoxiu Liu David V. Huhman Lloyd W. Sumner Richard A. Dixon Guodong Wang | 2013 | Molecular Plant2013，6，4： | 9 |
| 9 | Classification and Grading of Gastritis: The Updated Sydney System显示文摘 | Michael F. Dixon Robert M. Genta John H. Yardley Pelayo Correa | 1996 | The American Journal of Surgical Pathology1996，，10： | 8 |
| 10 | Transcriptome Analysis of Arabidopsis Wild-Type and gl3-sst sim Trichomes Identifies Four Additional Genes Required for Trichome Development显示文摘 | M. David Marks Jonathan R Wenger Edward Gilding Ross Jilk Richard A. Dixon | 2009 | Molecular Plant2009，2，4： | 8 |
| 11 | AU-rich element-binding proteins in colorectal cancer显示文摘Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called 'Adenylate-Uridylate-rich elements binding proteins'(AUBPs)control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation-and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules(also known as P-body/SG). Alterations in the expression and activities of AUBPs and Pbody/SG assembly have been observed to occur with colorectal cancer(CRC)progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC tumorigenesis.Accordingly, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation,along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality worldwide and, therefore, targeting these AUBPs to restore efficient post-transcriptional regulation of gene expression may represent an appealing therapeutic strategy. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2019 | World Journal of Gastrointestinal Oncology2019，11，2： | 7 |
| 12 | Can endoscopic atrophy predict histological atrophy? Historical study in United Kingdom and Japan显示文摘AIM: To assess the diagnostic concordance between endoscopic and histological atrophy in the United Kingdom and Japan.METHODS: Using published data,a total of 252 patients,126 in the United Kingdom and 126 in Japan,aged 20 to 80 years,were evaluated. The extent of endoscopic atrophy was classified into five subgroups according to a modified Kimura-Takemoto classification system and was compared with histological findings of atrophy at five biopsy sites according to the updated Sydney system.RESULTS: The strength of agreement of the extent of atrophy between histology and visual endoscopic inspection showed good reproducibili ty,wi th a weighted kappa value of 0.76(P < 0.001). Multivariate analysis showed that three factors were associated with decreased concordance: Japanese ethnicity [odds ratio(OR) 0.22,95% confidence interval(CI) 0.11-0.43],older age(OR = 0.32,95%CI: 0.16-0.66) and endoscopic atrophy(OR = 0.10,95%CI: 0.03-0.36). The strength of agreement between endoscopic and histological atrophy,assessed by cancer risk-oriented grading,was reproducible,with a kappa value of 0.81(95%CI: 0.75-0.87). Only nine patients(3.6%) were endoscopically underdiagnosed with antral predominant rather than extensive atrophy and were considered false negatives.CONCLUSION: Endoscopic grading can predict histological atrophy with few false negatives,indicating that precancerous conditions can be identified during screening endoscopy,particularly in patients in western countries. | Shin Kono Takuji Gotoda Shigeaki Yoshida Ichiro Oda Hitoshi Kondo Luigi Gatta Greg Naylor Michael Dixon Fuminori Moriyasu Anthony Axon | 2015 | World Journal of Gastroenterology2015，21，46： | 6 |
| 13 | 恶性肿瘤患者特质心理韧性量表的科学性考评显示文摘目的:对前期开发的恶性肿瘤患者特质心理韧性量表(RS-SC)进行临床检验。方法:对250例来自广州中医药大学第一附属医院、广东省中医院的恶性肿瘤患者进行问卷调查,采用双参数项目反应理论(IRT)模型对RS-SC进行分离指数、阈值、区分度、残差拟合度等参数进行检验。结果:RS-SC仍保留25条目的三维度结构,各维度的Cronbach’sα为0.814-0.851,条目分离指数为0.891-0.945,累积方差解释量为67.38%;25个条目难度分布均匀,区分度在0.34-0.99之间,残差拟合度都在-2.5~2.5之间,阈值间距在0.06-6.95 logits之间。结论:RS-SC具有良好的三维度结构,各条目的信息拟合度较高(部分条目需要进行后期调整),适合在中国恶性肿瘤患者中使用。 | 叶增杰 梁木子 余远亮 Knobf Tish Dixon Jane Chen Wei-Ti 邱鸿钟 | 2018 | 中华中医药杂志2018，33，5： | 5 |
| 14 | 《连动结构--跨语言的类型学视角》介绍显示文摘《连动结构——跨语言的类型学视角》(Serial Verb Constructions:A Cross-Linguistic Typol—ogy)是由A.Y.Aikhenvald和R.M.WDixon主编、牛津大学出版社出版的“语言类型学探索”(Explorations in Linguistic Typology)系列丛书之一,2006年出版,全书共16章,369页。 | A.Y. Aikhenvald R. M.W. Dixon 何彦诚 | 2011 | 当代语言学2011，13，1： | 5 |
| 15 | Dystrophic calcification and heterotopic ossification in fibrocartilaginous tissues of the spine in diffuse idiopathic skeletal hyperostosis(DISH)显示文摘Diffuse idiopathic skeletal hyperostosis(DISH) is a prevalent noninflammatory spondyloarthropathy characterized by ectopic mineral formation along the anterolateral aspect of the vertebral column, yet little is known about its underlying pathogenesis. Our objective was to evaluate the histopathological features and composition of ectopic mineral within spinal tissues affected by DISH in humans. Thoracic spine segments from six embalmed cadaveric donors(one female and five males;median age 82 years)meeting the radiographic diagnostic criteria for DISH were evaluated using radiological, histological, and physical analyses. Overall,the histological features of ectopic mineralization at individual motion segments were heterogeneous, including regions of heterotopic ossification and dystrophic calcification. Heterotopic ossifications were characterized by woven and lamellar bone,multifocal areas of metaplastic cartilage, and bony bridges along the anterior aspect of the intervertebral disc space. Dystrophic calcifications were characterized by an amorphous appearance, a high content of calcium and phosphorus, an X-ray diffraction pattern matching that of hydroxyapatite, and radiodensities exceeding that of cortical bone. Dystrophic calcifications were found within the anterior longitudinal ligament and annulus fibrosus in motion segments both meeting and not meeting the radiographic criteria for DISH. In summary, our findings indicate that in DISH, ectopic mineral forms along the anterior aspect of the spine by both heterotopic ossification and dystrophic calcification of fibrocartilaginous tissues. Although both types of ectopic mineralization are captured by current radiographic criteria for DISH, dystrophic calcification may reflect a distinct disease process or an early stage in the pathogenesis of DISH. | Dale E.Fournier Patti K.Kiser Ryan J.Beach S.Jeffrey Dixon Cheryle A.Séguin | 2020 | Bone Research2020，8，2： | 4 |
| 16 | Living vs. deceased donor liver transplantation for hepatocellular carcinoma: a systematic review and meta‐analysis显示文摘 | Robert C. Grant Lakhbir Sandhu Peter R. Dixon Paul D. Greig David R. Grant Ian D. McGilvray | 2012 | Clin Transplant2012，，1： | 4 |
| 17 | 脉冲涡流和电磁声换能器双探头无损检测显示文摘在许多情况下,只应用一种NDT技术存在不足,这就迫使NDT操作人员使用一种以上的技术以保证检测出危害被检物使用寿命或功能的缺陷。但分别实施多种技术的检测,就会延长检验时间。介绍了一种新的NDT设施,采用两种不同的非接触无损检测技术进行互补,即电磁声换能器(EMAT)和脉冲涡流(PEC)探头。检测结果表明,脉冲涡流和电磁声换能器因是非接触,所以可应用于材料生产过程中的自动在线检验,也可用于在役检验。 | Ali Sophian Rachel S Edwards 田贵云 Steve Dixon 马铭刚 | 2007 | 无损检测2007，29，8： | 4 |
| 18 | Stress granules in colorectal cancer:Current knowledge and potential therapeutic applications显示文摘Stress granules(SGs)represent important non-membrane cytoplasmic compartments,involved in cellular adaptation to various stressful conditions(e.g.,hypoxia,nutrient deprivation,oxidative stress).These granules contain several scaffold proteins and RNA-binding proteins,which bind to mRNAs and keep them translationally silent while protecting them from harmful conditions.Although the role of SGs in cancer development is still poorly known and vary between cancer types,increasing evidence indicate that the expression and/or the activity of several key SGs components are deregulated in colorectal tumors but also in pre-neoplastic conditions(e.g.,inflammatory bowel disease),thus suggesting a potential role in the onset of colorectal cancer(CRC).It is therefore believed that SGs formation importantly contributes to various steps of colorectal tumorigenesis but also in chemoresistance.As CRC is the third most frequent cancer and one of the leading causes of cancer mortality worldwide,development of new therapeutic targets is needed to offset the development of chemoresistance and formation of metastasis.Abolishing SGs assembly may therefore represent an appealing therapeutic strategy to re-sensitize colon cancer cells to anti-cancer chemotherapies.In this review,we summarize the current knowledge on SGs in colorectal cancer and the potential therapeutic strategies that could be employed to target them. | Noémie Legrand Dan A Dixon Cyril Sobolewski | 2020 | World Journal of Gastroenterology2020，26，35： | 4 |
| 19 | 新疆准噶尔盆地猎隼(Falco cherrug)繁殖期食性及其对鼠类的防控显示文摘2005年3~7月在新疆卡拉麦里山地区和北塔山地区的猎隼(Falco cherrug)食性研究中发现鼠类是其主要食物.调查中收集到猎隼食团342个,其中有鼠毛出现的食团是287个,占到83.9%.有鼠骨出现的食团是117个,占到34.2%.在鉴定出来的117个残留物种类中,大沙鼠出现次数超过15次.根据目击的结果分析,鼠类在食物种类中占绝对优势.由于繁殖季节对鼠类大量捕食,猛禽类能在生物防治鼠害中起到积极的作用. | 吴逸群 马鸣 徐峰 Andrew Dixon Dimitar Ragyov | 2006 | 新疆农业大学学报2006，29，2： | 4 |
| 20 | Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury显示文摘Traumatic brain injury(TBI)poses a significant socioeconomic burden in the world.The long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear.In this perspective,cholinergic dysfunction and therapeutic strategy targeting this will be reviewed.Novel agents that can target specific subtype of acetylcholine receptors have been developed over the recent years and | Samuel S.Shin C.Edward Dixon | 2015 | Neural Regeneration Research2015，10，10： | 3 |
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