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| 1 | 江陵天星观1号楚墓显示文摘天星观1号墓位于江陵县观音垱公社五山大队境内,东临长湖,西距楚故都纪南城约30公里(图一)。清时曾在该墓封土堆上修建过'天星观'道观一座,因此而得名。五山大队境内自东向西弧形排列五个大土塚,1号墓位于'五山'东侧,是'五山'之中最大的一个,海拔40.4米(图版拾壹,1)。 | The Jingzhou District Museum, Hubei Province | 1982 | 考古学报1982，，1： | 168 |
| 2 | CHA2007年患者安全目标暨主要措施显示文摘1 提高医务人员对患者识别的准确性,严格执行三查七对制度
(1)健全与完善患者识别制度,至少在抽血、给药或输血时,必须严格执行三查七对制度,应至少同时使用二种患者识别的方法(不得仅以床号作为识别的依据)。 | Chinese Hospital Association, Heping Street, Chaoyang District, Beijing, 100013, PRC | 2007 | 中国医院2007，11，1： | 54 |
| 3 | Ultrasonography guided percutaneous radiofrequency ablation for hepatic cavernous hemangioma显示文摘AIM: Hepatic cavernous hemangioma (HCH) is the mostcommon benign tumor of the liver and its management isstill controversial. Recent successin situ radiofrequencyablation of hepatic malignancies has led us to consider usingthis technique in patients with HCH. This study was to assessthe efficacy, safety, and complications of percutaneousradiofrequency ablation (PRFA) under ultrasonographyguidance in patients with HCH.METHODS: Twelve patients (four men and eight women,age ranged 33-56 years, mean age was 41.7 years) with 15hepatic cavernous hemangiomas (2.5 cm to 9.5 cm) weretreated using the RF-2000 generator and 10-needle LeVeenelectrode percutaneously guided by B-ultrasound. Lesionslarger than 3 cm were treated by multiple overlappingablations that encompass the entire lesion as well as a rimof normal liver tissue (approximately 0.5 cm).RESULTS: All the patients who received PRFA therapy hadno severe pain, bleeding or bile leakage during and afterthe procedures. Nine to 34 months′ follow-up (mean, 21months) by ultrasound and/or spiral CT scan demonstratedthat the ablated lesions in this group were shrunk remarkably,and the shrunken range was 38-79 % (mean, 67 % per 21months). The contrast enhancement was disappeared withinthe tumor or at its periphery in all cases on spiral CT scansobtained 3 to 6 months after treatment.CONCLUSION: The results of this study suggest that PRFAtherapy is a mini-invasive, simple, safe, and effective methodfor the treatment of selected patients with HCH. | Yan Cui Li-Yan Zhou Man-Ku Dong Ping Wang Min Ji Xiao-Ou Li Chang-Wei Chen Zi-Pei Liu Yong-Jie Xu Hong-Wen Zhang Department of Hepatobiliary Surgery,Beijing 306 Hospital,Chaoyang District,Beijing 100101,China | 2003 | World Journal of Gastroenterology2003，9，9： | 43 |
| 4 | Estimation of internal nutrient release in large shallow Lake Taihu, China显示文摘Based on field investigation of wave, sediment suspension and the changes in nutrient concentration of the water column in Lake Taihu, China, we proposed two release models to quantify nutrient release under static and dynamic conditions, respectively. Under static conditions, nutrient release from sediments to the overlying water mainly depends on chemical diffusion induced by concentration gradient, in which the nutrient release is controlled by the temperature, dissolved oxygen concentration in the sediment-water interface, oxidation-reduction potential and the concentration difference between porewater and overlying water. Under dynamic condition (or disturbed condition),both dissolved and particulate nutrients in sediments are released into the water column because of wind-induced sediment suspension. The amount of nutrient release under dynamic conditions is larger than that under the static condition. The release of dissolved nutrients, however, does not increase because the wind induced turbulence made oxidation of metallic elements such as Fe (ferric iron), Mn which are capable of precipitating soluble reactive phosphate (SRP). Under dynamic conditions, therefore, the release of total phosphorus (TP) increases dramatically but the release of SRP is close to those under static conditions. In sediments of Lake Taihu, high Fe content leads to a high ratio of Fe to P contents in sediments (Fe:P ratio). Under dynamic conditions, therefore, nutrient release is controlled by the intensity of disturbance, sediment consolidation and nutrient content in sediments.As for dissolved nutrients, especially SRP, the release is also controlled by the intensity of dynamic re-oxidation, Fe content in sediments and nutrient concentration gradient between porewater and overlying water. Based on these two release modes, the release flux in Lake Taihu has been estimated. In the static condition (i.e. laboratory experimental condition), total release of NH4+-N for whole lake is ca. 10,000 ton/a, and PO43--P is ca. 900 ton/a. In the dynamic condition, nutrient release following sediment suspension was estimated according to three different intensities of wind forcing which were defined as 'calm' (wind speed is less than 2 m/s), 'gentle' (wind speed is greater than 2 m/s and less than 6 m/s) and 'gust' (wind speed is greater than 6 m/s). The release rate in the condition of 'calm' was estimated in terms of the nutrient release in the laboratory experimental static condition; whereas the release rate in conditions of 'gentle' and 'gust' was estimated in terms of measurement during sediment resuspension conducted in flume experiments. With the observation of wind velocity and frequency in 2001, each type of wind forcing took the frequency of 12%, 82% and 6% for 'calm', 'gentle' and 'gust', respectively. The yearly release of nitrogen was 81,000 ton and phosphorus was 21,000 ton, which is about 2-6 folds of annual external loading, respectively. | QIN Boqiang, ZHU Guangwei, ZHANG Lu, LUO Liancong, GAO Guang & GU Binhe Nanjing Institute of Geography & Limnology, Chinese Academy of Sciences, Nanjing 210008, China Everglades Department, South Florida Water Management District, 3301 Gun Club Road, West Palm Beach, FL 33406, USA | 2006 | Science China Earth Sciences2006，49，z1： | 37 |
| 5 | Nuclear factor kB activity in patients with acute severe cholangitis显示文摘瞄准:在外部血决定 NF-kB 活动在有严重类型(ACST ) 和相互关联的尖锐胆管炎的病人的单音的原子房间(PBMC ) 有胆汁的道感染和临床的结果的严厉的 NF-kB 激活的度。方法:有 ACST 的二十个病人被划分成幸存者组(13 个盒子) 并且非幸存者组(7 个盒子) 。经历选任的 gastrectomy 或腹股沟的脱肠修理的另外的十个病人作为控制组被选择。外部血样品手术后地被花 24 个小时。PBMC 被密度坡度 centrifugation 分开,然后原子的蛋白质从 PBMC 被孤立,并且 Electrophoretic 活动性移动试金(EMSA ) 使用了坚定。结果被扫描一个简历图象分析系统的 densitometer 确定并且表示了同样相对的光密度(杆) 。在有 ACST 和健康控制题目的病人的血浆的 TNF-alpha, IL-6,和 IL-10 的层次被使用连接酶的免疫分析(ELISA ) 决定。结果:NF-kB 活动是 5.02 +/- 1.03 在里面非幸存者组, 0.51 在幸存者组织的 2.98 +/- 和 1.06 +/- 0.34 在控制组。在三个组(P<0.05 ) 有统计差别。在血浆的 TNF-alpha 和 IL-6 的层次是( 498 +/- 53 ) ng.L ( -1)and ( 587 +/- 64 ) ng.L ( -1)in 非幸存者组,( 284 +/- 32 ) ng.L (-1)并且( 318 +/- 49 ) ng.L ( -1)in 幸存者组并且( 89 +/- 11 ) ng.L (-1)并且( 102 +/-13 ) ng.L ( -1)in 控制组。有 ACST 的所有病人增加了 TNF-alpha 和 IL-6 的层次,它是控制组的比那些大的许多褶层,并且有一条证据在那些显著地高级非幸存者组比那在幸存者组(P<0.05 ) 。在血浆的 IL-10 的层次是(378+/-32 ) ng.L (-1),(384+/-37 ) ng.L (-1) 并且(68+/-11 ) ng.L (在三个组的 -1) 分别地。当与控制相比组(P<0.05 ) ,而是 IL-10 层次不是显著地更高级的在时,所有病人也增加了 IL-10 的层次非幸存者比在幸存者(P>0.05 ) 。结论:在在有 ACST 的病人的 PBMC 的 NF-kB 活动显著地增加并且 NF-kB 激活的度与胆汁的道感染和临床的结果的严厉被相关。 | Jian-Ping Gong Chong-An Liu Chuan-Xin Wu Sheng-Wei Li Yu Jun Shi Xu-Hong Li,Department of General Surgery,The Second College of Clinical Medicine & the Second Affiliated Hospital of Chongqing University of Medical Science,74 Linjiang Road,Central District,Chongqing 400010,China | 2002 | World Journal of Gastroenterology2002，8，2： | 31 |
| 6 | microRNA-181b targets MLK2 in HL-60 cells显示文摘microRNAs(miRNAs) play critical roles in many different cellular processes,including metabolism,apoptosis,differentiation and development.We showed miR-181b to be highly expressed in acute myeloid leukemia(AML).Furthermore,miR-181b contributed to proliferation of AML cells by targeting MLK2.Our results demonstrated that miR-181b plays an important role in the biology of AML and may be useful in developing therapies targeting miRNAs. | CHEN Hong1,CHEN Qun2,FANG Ming3 & MI Yan1 1 The First Affiliated Hospital of Harbin Medical University,Harbin 150101,China 2 Harbin Acheng District People’s Hospital,Harbin 150300,China 3 Graduate Department of Harbin Medical University,Harbin 150001,China | 2010 | Science China(Life Sciences)2010，53，1： | 20 |
| 7 | 重症加强治疗病房(ICU)建设与管理指南(2006)显示文摘 | Society of Critical Care Medicine, Chinese Medical Association. No.1, Shuaifuyuan, Dongcheng District, Beijing. 100730, PRC | 2006 | 中国医院2006，10，7： | 9 |
| 8 | The expression of glucose regulated protein-94 in colorectal carcinoma cells treated by sodium butyrate显示文摘The expression of glucose regulated protein 94 (GRP94)during the treatment of human colorectal carcinoma cell lineClone A cells with sodium butyrate was studied. Sodium butyrate (SB) can cause functional and morphological effects on Clone A cells including growth arrest at Go/G1 stage and cell differentiation as observed by morphological changes, MTT and flow cytometry assays, as well as reduced Grp94 gene expression as shown by Northern blot and Western blot assays. The possible mechanism of the correlation between Grp94 gene expression and tumor growth inhibition and cell differentiation is briefly discussed. | WU YI DI JIN DAN SONG( Fax: (024)23256087 E-mail: jdsong@sun10.cmu.edu.cn)(Key Laboratory of Cell Biology, Ministry of Public Health of ChinaInstitute of Medical Molecular Biology, China Medical University, 92 Beier Rd. Heping District, Shenyang 110001, | 2000 | Cell Research2000，10，2： | 9 |
| 9 | 大兴安岭呼中林区狍冬季卧息生境的选择显示文摘大兴安岭呼中林区狍冬季卧息生境的选择关键词狍子,卧息点选择,大兴安岭WINTERRESTINGSITESELECTIONBYROEDEERATHUZHONG,DAXINGANLINGMOUNTAINSNORTHEASTERNCHINA￥JiangZh... | Jiang Zhaowen Xu Li(Institute of Natural Resources,Heilongjang Academy of Sciences Harbin 150040)Wang Yongqing(Daxinganling District Forestry Resource and Policy Administrative Bureau)Jiao Peirong Liu Hongfa(Resouce Management Section,Huzhong,Daxingonling | 1996 | Zoological Research1996，17，2： | 8 |
| 10 | Duodenoscopy in treatment of acute gallstone pancreatitis显示文摘Objective: To probe the potential use of duodenosco-py in the diagnosis and treatment of acute gallstonepancreatitis (GP).Methods: Fourty-five patients with acute GP wererandomly divided into endoscopic retrograde cholan-giopancreatography (ERCP) group (n=20) andnon-ERCP group (n=25). Each group was subdivi-ded into mild and severe groups according to A-PACHE Ⅱ scores. They were given supportive treat-ment combined with traditional Chinese medicine.The patients in the ERCP group received ERCPwithin 24 hours after admission. If there were stonesin the common bile duct with stenosis of the inferiorextremity or ampulla, endoscopic sphincterotomy(ES) was performed to extract the stones by basket.If no calculi were identified or multiple stones werelarge, endoscopic naso-biliary drainage (ENBD) wascarried out.Results: The incidence of complication, length ofhospitalization and cost were markedly lower in pa-tients with severe acute GP in the ERCP group thanthose in the non-ERCP group (P<0.05), in contrastto the 2 mild subgroups of the ERCP and non-ERCPgroups (P>0.05).Conclusion: It is feasible, effective and safe to applyduodenoseopy in the treatment of severe acute GP. | Ming-Qing Zhou Neng-Ping Li Ren-Da Lu the Department of Surgery, Central Hospital of Zhabei District, Shanghai 200070, China | 2002 | Hepatobiliary & Pancreatic Diseases International2002，1，4： | 8 |
| 11 | Anatomy of the lateral ligaments of the rectum: A controversial point of view显示文摘The existence and composition of the lateral ligaments of the rectum (LLR) are still the subjects of anatomical confusion and surgical misconception up to now. Since Miles proposed abdominoperineal excision as radical surgery for rectal cancer, the identification by 'hooking them on the finger' has been accepted by many surgeons with no doubt; clamping, dividing and ligating are considered to be essential procedures in mobilization of the rectum in many surgical textbooks. But in cadaveric studies, many anatomists could not find LLR described by the textbooks, and more and more surgeons also failed to find LLR during the proctectomy according to the principle of total mesorectal excision. The anatomy of LLR has diverse descriptions in literatures. According to our clinical observations, the traditional anatomical structures of LLR do exist; LLR are constant dense connective bundles which are located in either lateral side of the lower part of the rectum, run between rectal visceral fascia and pelvic parietal fascia above the levator ani, and covered by superior fascia of pelvic diaphragm. They are pathways of blood vessels and nerve fibers toward the rectum and lymphatic vessels from the lower rectum toward the iliac lymph nodes. | Guo-Jun Wang, Chun-Fang Gao, Dong Wei, Cun Wang, Wen-Jian Meng, Institute of Digestive Surgery and Department of General Surgery, 150 Hospital of PLA, Gaoxin District, Luoyang 471031, Henan Province, China | 2010 | World Journal of Gastroenterology2010，16，43： | 8 |
| 12 | 医学模型分类及世界研发商显示文摘医学模型架起医学理论通往临床实践的桥梁。基础解剖示教模型、局部功能性模型、计算机互动模型、虚拟培训系统、生理驱动模拟系统,这五部分各自具有不同功能,在医学生培养中缺一不可。生理驱动模拟系统再造“真实临床环境”,帮助医学生最终实现临床梦想。 | Academy and marketing Department of Rizheng Huarui Enterprise LuSun Wyatt(Ri Zheng Hua Rui) China Co.,Ltd., No.9, Fangzhuang Nanlu, Fengtai District, Beijing, 100079, PRC | 2007 | 中国医院2007，11，4： | 7 |
| 13 | Preparation and characterization of chitosan porous microcarriers for hepatocyte culture显示文摘BACKGROUND: The bioartificial liver (BAL) is considered a possible alternative method for treating liver failure. The core of the BAL system is culturing liver cells in vitro with high density and activity. Microcarrier culture is a mode of high-density culture. We set out to prepare a novel porous microcarrier to improve the activity of liver cells in vitro. METHODS: Chitosan was used to prepare a novel porous spherical microcarrier with interconnected structure. The chitosan porous microcarriers (CPMs) were modified with gelatin to improve their biocompatibility. CPMs were co-cultured with liver cells, HL-7702 (L-02), to evaluate their effect on cell culture. RESULTS: The average size of the CPMs was about 400 μm in diameter and their apertures were less than 30 μm. The pores of the microcarrier were interconnected. After fixation by sodium tripolyphosphate, the structure of the first freeze-dried CPMs was stable. To further improve the biocompatibility, the surface of CPMs was modified with gelatin through chemical crosslinking (GM-CPMs). Comparing the proliferation curves of L-02 cells cultured on simple CPMs, GM-CPMs and tissue culture polystyrene (TCPS, a mode of planar cell culture), the proliferation rates were similar in the first 5 days and the cells proliferated until day 8 in culture with microcarriers. The OD value of liver cells cultured on GM-CPMs was 1.97-fold higher than that on TCPS culture at day 8. Levels of urea and albumin in supernatants of cells cultured on GM-CPMs increased steadily for 8 days, and were clearly higher than those of cells cultured on TCPS (P<0.05).CONCLUSIONS: The novel CPMs were promising microcarriers for hepatocyte culture and the GM-CPM seemed better. Porous microcarrier culture was beneficial for hepatocyte function and activity. | Xu-Bo Wu, Cheng-Hong Peng, Fang Huang, Jie Kuang, Song-Lin Yu, Ya-Dong Dong and Bao-San Han Center of Organ Transplantation, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of General Surgery, Central Hospital, Minhang District, Shanghai 201100, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 6 |
| 14 | 当前中国煤炭经济运行态势分析显示文摘通过大量数据表述了2009年以来我国煤炭经济运行的基本态势为:煤炭市场供需基本保持平稳,煤炭产运量明显减少。近期国家出台的一系列促进经济增长的政策措施,对煤炭行业稳定发展发挥着积极作用,并针对需要进一步解决的问题,提出了相应的对策措施及其建议。 | China National Coal Association(Hepingli Beijie 21,Dongcheng District,Beijing 100713,China) | 2009 | 中国煤炭2009，，2： | 6 |
| 15 | Clinical Observation of Pregnancy with Chlamydia Trachomatis Infection.显示文摘From 1992 to 1993, 1 389 cases of pregnancy at 12-20 gestational weeks were investigated. At first antenatal visit the samples of cervical secretion were taken for chlamydia trachomatis antigen test and blood samples were tested for antidody simultaneously. Micro immunofluorescence | Ding Ying et al. Shanghai Changning District Women’s Hospital, Shanghai 200052 | 1995 | Chinese Medical Journal1995，，7： | 6 |
| 16 | Hepatocyte differentiation of mesenchymal stem cells显示文摘BACKGROUND:Liver cell transplantation and bioartificial liver may provide metabolic support of liver function temporary and are prospective treatments for patients with liver failure.Mesenchymal stem cells(MSCs) are expected to be an ideal cell source for transplantation or liver tissue engineering,however the hepatic differentiation of MSCs is still insufficient for clinical application.DATA SOURCES:A PubMed search on 'mesenchymal stem cells','liver cell' and 'hepatocyte differentiation' was performed on the topic,and the relevant articles published in the past ten years were reviewed.RESULTS:Hepatocyte-like cells differentiated from MSCs are a promising cell source for liver regeneration or tissue engineering.Although it is still a matter of debate as to whether MSC-derived hepatocytes may efficiently repopulate a host liver to provide adequate functional substitution,the majority of animal studies support that MSCs can become key players in liver-directed regenerative medicine.However the clinical application of human stem cells in the treatment of liver diseases is still in its infancy.CONCLUSIONS:Future studies are required to improve the efficacy and consistency of hepatic differentiation from MSCs.It is necessary to better understand the mechanism to achieve transdifferentiation with high efficiency.More clinical trials are warranted to prove their efficacy in the management of patients with liver failure. | Xu-Bo Wu Department of General Surgery,Central Hospital of Minhang District,Ruijin Medical Group,Shanghai 201199,China Ran Tao Center for Organ Transplantation,Department of General Surgery,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，4： | 5 |
| 17 | 国家电网风电场接入电网技术规定(试行)显示文摘 | State Grid Companies of China(West Chang’an Street 86,Xicheng District,Beijing 100031,China) | 2009 | 山西能源与节能2009，，5： | 5 |
| 18 | Molecular epigenetics: dawn of a new era of biomedical research显示文摘At about the same time in 1940s when Erwin Schrdinger published his famous little book What Is Life, which sparked the birth of molecular biology, the term epigenetics was coined by the English biologist Conrad Waddington. The concept of epi-inheritance can be traced back to French naturalist Jean-Baptiste Lamarck’s idea of 'inheritance | XU Rui-Ming Institute of Biophysics, Chinese Academy of Sciences 15 Datun Road, Chaoyang District, Beijing 100101, China | 2009 | Science China(Life Sciences)2009，52，4： | 5 |
| 19 | Protective Effect of Dimethyl-4,4'-Dimethoxy-5,6,5',6'-Dimethylene Dioxybiphenyl-2,2'-Dicarboxylate (DDB) against Carcinogen-Induced Rat Liver Nuclear DNA Damage显示文摘The protective effect fDDB against carcinogen-induced DNA damage was examined in the present investigation.Preincubation of rat liver nuclei with DDB(1mmol·L^-1)resulted in 60% inhibition of binding of ^3H-benzo(a)pyrene to nuclear DNA.unscheduled DNA synthesis(UDS)induced by aflatoxin B1(10^-7mol·L^-1) in freshly isolated rat hepatocytes was also inhibited by DDB(10^-6-10^-3mol·L^-1).Oral administation of DDB at 200mg·k^-1once daily for 3 d induced a significant increase of liver cytosol glutathione-S-transferase and microsomal UDPG-transferase activity in mice.These results indicate that DDB is able to directly or indirectly antagonize certain carcinogen-induced DNA damages. | QlNG WEIGUO1 AND LIU GENGTAODepartment of Pharmacology, Institute of Materia Medico, Chinese Academy of Medical Sciences, 1 Xian Nong Tan Street, Beijing 100050,ChinaBeijing Institute for Cancer Research, Da-Hong-Luo-Chang Street, West District, Beijing, 100034 China.To whom correspondence should be addressed. | 1992 | Biomedical and Environmental Sciences1992，5，3： | 4 |
| 20 | 龙窝湖斜颌鲴生态调查报告显示文摘斜颌鲴是一种重要的野生经济鱼类,分布于我国黑龙江、长江、珠江流域(伍献文等。《中国鲤科鱼类志》上卷)。 | Fisheries Administrative Board of Lake Lungwohu,Fanchang County,Anhwei Province Fisheries Administrative Station of Wuhu District,Anhwei Province Section of Introduction and Acclimation,the 2nd Laberatory,Institute of Hydrobiology,Hupei Province | 1977 | 水生生物学集刊1977，6，2： | 4 |
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