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| 1 | Reduced semen quality in patients with testicular cancer seminoma is associated with alterations in the expression of sperm proteins显示文摘Testicular cancer seminoma is one of the most common types of cancer among men of reproductive age.Patients with this condition usually present reduced semen quality,even before initiating cancer therapy.However,the underlying mechanisms by which testicular cancer seminoma affects male fertility are largely unknown.The aim of this study was to investigate alterations in the sperm proteome of men with seminoma undergoing sperm banking before starting cancer therapy,in comparison to healthy proven fertile men(control group).A routine semen analysis was conducted before cryopreservation of the samples(n=15 per group).Men with seminoma showed a decrease in sperm motility(P=0.019),total motile count(P=0.001),concentration(P=0.003),and total sperm count(P=0.001).Quantitative proteomic analysis identified 393 differentially expressed proteins between the study groups.Ten proteins involved in spermatogenesis,sperm function,binding of sperm to the oocyte,and fertilization were selected for validation by western blot.We confirmed the underexpression of heat shock-related 70 kDa protein 2(P=0.041),ubiquinol-cytochrome C reductase core protein 2(P=0.026),and testis-specific sodium/potassium-transporting ATPase subunit alpha-4(P=0.016),as well as the overexpression of angiotensin I converting enzyme(P=0.005)in the seminoma group.The altered expression levels of these proteins are associated with spermatogenesis dysfunction,reduced sperm kinematics and motility,failure in capacitation and fertilization.The findings of this study may explain the decrease in the fertilizing ability of men with seminoma before starting cancer therapy. | Tania R Dias Ashok Agarwal Peter N Pushparaj Gulfam Ahmad Rakesh Sharma | 2020 | Asian Journal of Andrology2020，22，1： | 2 |
| 2 | Stability of fruit quality traits in diverse watermelon cultivars tested in multiple environments显示文摘Lycopene is a naturally occurring red carotenoid compound that is found in watermelon.Lycopene has antioxidant properties.Lycopene content,sugar content and hollowheart resistance are subject to significant genotype×environment interaction(G×E),which makes breeding for these fruit quality traits difficult.The objectives of this study were to(i)evaluate the influence of years and locations on lycopene content,sugar content and hollowheart resistance for a set of watermelon genotypes,and(ii)identify genotypes with high stability for lycopene,sugar,and hollowheart resistance.A diverse set of 40 genotypes was tested over 3 years and 8 locations across the southern United States in replicated,multi-harvest trials.Lycopene was tested in a subset of 10 genotypes.Data were analyzed using univariate and multivariate stability statistics(BLUP-GGE biplot)using SASGxE and RGxE programs.There were strong effects of environment as well as G×E interaction on watermelon quality traits.On the basis of stability measures,genotypes were classified as stable or unstable for each quality trait.'Crimson Sweet'is an inbred line with high quality trait performance as well as trait stability.'Stone Mountain','Tom Watson','Crimson Sweet'and'Minilee'were among the best genotypes for lycopene content,sugar content and hollowheart resistance.We developed a stability chart based on marketable yield and average ranking generated from different stability measures for yield attributes and quality traits.The chart will assist in choosing parents for improvement of watermelon cultivars.See http://gffzz783b6e01a04243c3hko960qnv65nb6pbu.ffgz.tsg.suse.edu.cn/cucurbit/wmelon/wmelonmain.html. | Mahendra Dia Todd C Wehner Penelope Perkins-Veazie Richard Hassell Daniel S Price George E Boyhan Stephen M Olson Stephen R King Angela R Davis Gregory E Tolla Jerome Bernier Benito Juarez | 2016 | Horticulture Research2016，3，1： | 2 |
| 3 | Robust H∞ filtering for uncertain discrete-time state-delayed 显示文摘 | Palhares R M SouzaQu C E Dias Peres P L | 2001 | IEEE Trans on Sig Processing2001，49，8： | 1 |
| 4 | Effect ofdietary carbohydrate - to - lipid ratios on growth,lipid deposition and metabolic hepatic enzymes injuvenile Senegalese sole ( Solea senegalensis, Kaup)显示文摘 | Dias J Rueda - Jasso R Panserat S | 2004 | Aquaculture Research2004，35，12： | 1 |
| 5 | Transvaginal ultrasonography and hysteroscopy as predictors of endometrial polyps in postmenopause 显示文摘 | de Godoy Borges PC Dias R Bonassi Machado R | 2015 | Womens Health (Lond Engl)2015，11，1： | 1 |
| 6 | 术中脑组织氧分压偏低与动脉瘤性蛛网膜下腔出血术后血管痉挛相关(英文)显示文摘Background Vasospasm is a frequent complication of subarachnoid hemorrhage ( SAH) ,implicated in poor outcome,and prediction of its occurrence might be important on the therapeutic approach of this condition. Brain oxygenation in aneurysmal SAH was prospectively monitored during surgery in 28 patients,using brain tissue oxygen pressure ( PbtO 2 ) ,studying its association with the occurrence of post-operative vasospasm,detected by transcranial Doppler. Methods PbtO 2 monitoring was performed during surgery of 28 patients with aneurysmal SAH,using a polarographic microcatheter ( Licox; GMS,Kiel,Germany) ,inserted into the cerebral tissue. The aneurysms were localized in the anterior communicating artery ( AcoA) complex ( eight cases) ,in the posterior communicating artery ( Pcom) origin ( seven cases) ,and in the middle cerebral artery ( MCA) bifurcation ( 13 cases) . Basal PbtO 2 values,obtained immediately before application of temporary or definitive clips,were studied according to age,clinical status and CT findings. The association between the basal values and the occurrence of increased blood flow velocity in the post-operative transcranial Doppler ( TCD vasospasm) was investigated. Results Post-operative TCD vasospasm developed in 13 patients,all of them with basal values inferior to 10 mmHg. PbtO 2 basal value was significantly lower in cases that developed TCD vasospasm. This association was independent of age, clinical status,or CT findings. Conclusion The finding of low intraoperative basal PbtO 2 values may be an indicator for a high risk of occurrence of post-operative TCD vasospasm in cases of aneurysmatic SAH. | Cerejo A Silva PA Vilarinho A Dias C Vaz R | 2012 | 中华神经外科疾病研究杂志2012，11，5： | 1 |
| 7 | 显示文摘 | Portela M F | 1995 | J Catal1995，157，： | 1 |
| 8 | Oxidative stress in diabetes-circulating advanced glycation end products, lipid oxidation and vascular disease显示文摘 | Dias I H riffiths H R | 2014 | Annals of Clinical Biochemistry2014，51，2： | 1 |
| 9 | Effect of experimental conditions on cogasification of coal,biomass and plastics wastes with air/steam mixtures in a fluidized-bed system显示文摘 | PINTO F FRANCO C ANDRE R TAVARES C DIAS M GULYURTLU I CABRITA I | 2003 | Fuel2003，82，1517： | 1 |
| 10 | Lipoprotein(a)and risk of cardiovascular disease--a systematic review and meta analysis of prospective studies显示文摘 | Genser B Dias KC Siekmeier R | 2011 | Clin Lab2011，57，34： | 1 |
| 11 | Seawater Sr isotope variation over the past 300 kyr and influence of global climate cycles 显示文摘 | Dia A N Cohen A S O'Nions R K | 1992 | Nature1992，356，： | 1 |
| 12 | Analysis and simu-lationonrural energy-economy System on Sheyang County in China显示文摘 | X H Wang Y R Hu X Q Dia | 2006 | Renewable and Sustainable Energy Reviews2006，10，： | 1 |
| 13 | Enzymatic kinetic of cel- lulose hydrolysis-Inhibition by ethanol and cellobiose 显示文摘 | BEZERRA R M F DIAS A A | 2005 | Applied Biochemistry and Biotechnology2005，126，1： | 1 |
| 14 | Prognostic factors and out- come for nasopharyngeal carcinoma 显示文摘 | Farias T P Dias F L Lima R A | 2003 | Arch Otolalyngol Head Neek Surg2003，129，7： | 1 |
| 15 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 16 | Risk factors associated with sero-positivity to Toxoplasma gondii in captive neotropical felids from Brazil显示文摘 | Ramossilva J C Marvulo M F Dias R A | 2007 | Prey Vet Med2007，78，34： | 1 |
| 17 | Exploring the potential of fimctionally graded materials concept for the development of fiber cement显示文摘 | Dias C M R Savastano Jr H John V M | 2010 | Construction and Building Materials2010，24，： | 1 |
| 18 | Measurement of Host-to-Activator Transfer Efficiency in Nano-Crystalline Y2 03:Eu3 + under VUV Excitation显示文摘 | Waite C Mann R Dias A L | 2013 | Journal of Solid State Chemistry2013，198，： | 1 |
| 19 | Supracricoid laryngectomy with cricohyoidoepiglottopexy for advanced glottic cancer显示文摘 | LIMA R A FREITAS E Q DIAS F L | 2006 | Head Neck2006，28，： | 1 |
| 20 | Toxoplasma gondii in fresh pork sausage and seroprevalence in butchers from factories in Londrina,Paraná State,Brazil显示文摘 | Dias R A Navarro I T Ruffolo B B | 2005 | Rev Inst Med Trop Sao Paulo2005，47，4： | 1 |
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