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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | A parallel sort merge JOIN algorithm for managing data skew显示文摘 | Wolf J L Dias D M Yu P S | 1993 | IEEE Transactions Parallel and Distributed Systems1993，4，1： | 2 |
| 3 | Evaluation of brain natri-uretic peptide in the diagnosis of heart failure显示文摘 | Bettenc Ourt P Ferreira A Dias P | 2000 | Cardiology2000，93，： | 1 |
| 4 | Hydrophobic, highly conductive ambient-temperature molten salts显示文摘 | Bomhote P Dias A P Papageorgiou N | 1996 | Inorg Chem1996，35，： | 1 |
| 5 | Robust H∞ filtering for uncertain discrete-time state-delayed 显示文摘 | Palhares R M SouzaQu C E Dias Peres P L | 2001 | IEEE Trans on Sig Processing2001，49，8： | 1 |
| 6 | Risk of human exposure to paralytic loxlns of algal origin显示文摘 | Batoreu M C C Dias E Pereira P | 2005 | Environmental Toxicology and Pharmacology2005，19，： | 1 |
| 7 | Adhesion of statistical andblocky ethylene-octene polypropylene显示文摘 | Dias P J Lin Y Poon B | 2008 | Polymer2008，49，： | 1 |
| 8 | Novel antiviral thera- peutics to control foot - and - mouth disease 显示文摘 | DIAS C C MORAES M P WEISS M | 2012 | J Interferon Cyto- kine Res2012，32，10： | 1 |
| 9 | The flavonoid rich fraction of Coreopsis tinctoria promotes glucose tolerance regain through pancreatic function recovery in streptozotocin induced glucose intolerant rats显示文摘 | T Dias MR Bronze P J Houghton | 2010 | Journal of Ethnophannacology2010，132，： | 1 |
| 10 | Availability of phosphorus in a Brazilian Oxisol cultivated with Eucalyptus after nine years as influenced by phosphorus-fertilizer source,rate and placement显示文摘 | DIAS L E FERNANDEZ J Q P BARROS N F | 2001 | Communications in soil science and plant analysis2001，32，78： | 1 |
| 11 | ATR-FTIR: studies of poly ( propylene oxide)/polybutadiene hi-soft segment urethane/urea membranes 显示文摘 | Queiroz D P De Pinho M N Dias C | 2003 | Macromolecules2003，36，11： | 1 |
| 12 | MyoD1 protein expression in alveolar soft part sarcoma as confimatory evidence of its skdetal muscle nature显示文摘 | Rosia J Dias P David M | 1991 | Am J surg pathol1991，，： | 1 |
| 13 | Vertex component analysis:a fast algorithm to unmix hyperspectral data显示文摘 | Nascimento J M P Dias J M B | 2005 | IEEE Transactions on Geoeienees and Remote Sensing2005，43，4： | 1 |
| 14 | Prognostic value of neutrophil gelatinase-associated lipocalin in acute heart failure 显示文摘 | Alvelos M Loureno P Dias C | 2013 | Int Urol Nephrol2013，165，1： | 1 |
| 15 | Value of frational flow reserve in the management of patients with moderate coronary stenosis 显示文摘 | Dias CC Mateus P Bettencourt N | 2004 | Rev Port Cardil2004，23，11： | 1 |
| 16 | Fracture toughness of geopolymetric concretes reinforced with basalt fibers显示文摘 | Dias D P Thaumaturgo C | 2005 | Cement and Concrete Composites2005，27，： | 1 |
| 17 | Prdictors of preognosis in patients with stable mild to moderateheartfailure显示文摘 | Bettencourt P Ferreira A Dias P | 2000 | JCard Fail2000，6，： | 1 |
| 18 | Reliability and validity of the spanish version of the GMS-AGECATE package for the assessment of dementia and cognitive disturbances显示文摘 | Saz P Dia JL De la Camara C | 1996 | Int J Geriatr Psychiatry1996，11，8： | 1 |
| 19 | Hydrophobic , highly conductive ambient-temperature molten salts 显示文摘 | Dias A P Papageorgiou N | 1996 | Inorg Chem1996，35，5： | 1 |
| 20 | Evaluation of brain natriuretic peptide in the diagnosis of heart failure显示文摘 | Bettencourt P Ferreira A Dias P | 2000 | Cardiology2000，93，： | 1 |
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