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| 1 | 成人退变性腰椎侧凸的分型及手术方法选择显示文摘[目的]探讨一种对手术治疗具有指导意义的成人退变性腰椎侧凸的临床分型。[方法]回顾性分析1994~2004年10年间手术治疗的成人退变性腰椎侧凸患者168例,根据站立位脊柱全长X线平片上椎体的旋转、前后或侧方移位程度以及冠状面和矢状面躯干的平衡分为三型。Ⅰ型:很小或没有旋转;Ⅱ型:明显旋转和移位;Ⅲ型:重度旋转和移位,伴有冠状面和/或矢状面躯干的不平衡(C2铅垂线偏移〉4cm)。再结合患者的临床症状和体征(腰痛及神经根性疼痛)分为三个亚型。A型:腰痛,不伴有神经根性痛;B型:来自腰骶部代偿侧凸的神经根性痛,伴或不伴腰痛;C型:来自主侧凸的神经根性痛,伴或不伴腰痛。[结果]ⅠA型3例,IB型28例,IC型6例;ⅡA型21例,ⅡB型45例,ⅡC型39例;ⅢA型12例,ⅢB型6例,ⅢC型8例。其中IA型以后外侧椎间融合或经椎间孔椎间融合为主;IB、IC型的手术方法以单纯椎管减压为主;ⅡA、ⅡB、ⅡC型以后路椎管减压加后外侧融合术为主;ⅢA、ⅢB、ⅢC以前路椎间融合加后路器械矫形、椎管减压及后外侧融合术为主。[结论]此分型简便实用,尤其对手术方法的选择具有指导意义。 | 刘洪 米川 Ploumis A Transfeldt E Denis F | 2010 | 中国矫形外科杂志2010，18，1： | 13 |
| 2 | Colon cancer-associated B2 Escherichia coli colonize gut mucosa and promote cell proliferation显示文摘AIM:To provide further insight into the characterization of mucosa-associated Escherichia coli(E.coli)isolated from the colonic mucosa of cancer patients.METHODS:Phylogroups and the presence of cyclomodulin-encoding genes of mucosa-associated E.coli from colon cancer and diverticulosis specimens weredetermined by PCR.Adhesion and invasion experiments were performed with I-407 intestinal epithelial cells using gentamicin protection assay.Carcinoembryonic antigen-related cell adhesion molecule 6(CEACAM6)expression in T84 intestinal epithelial cells was measured by enzyme-linked immunosorbent assay and by Western Blot.Gut colonization,inflammation and procarcinogenic potential were assessed in a chronic infection model using CEABAC10 transgenic mice.Cell proliferation was analyzed by real-time mRNA quantification of PCNA and immunohistochemistry staining of Ki67.RESULTS:Analysis of mucosa-associated E.coli from colon cancer and diverticulosis specimens showed that whatever the origin of the E.coli strains,86%of cyclomodulin-positive E.coli belonged to B2 phylogroup and most harbored polyketide synthase(pks)island,which encodes colibactin,and/or cytotoxic necrotizing factor(cnf)genes.In vitro assays using I-407 intestinal epithelial cells revealed that mucosa-associated B2 E.coli strains were poorly adherent and invasive.However,mucosa-associated B2 E.coli similarly to Crohn’s disease-associated E.coli are able to induce CEACAM6expression in T84 intestinal epithelial cells.In addition,in vivo experiments using a chronic infection model of CEACAM6 expressing mice showed that B2 E.coli strain11G5 isolated from colon cancer is able to highly persist in the gut,and to induce colon inflammation,epithelial damages and cell proliferation.CONCLUSION:In conclusion,these data bring new insights into the ability of E.coli isolated from patients with colon cancer to establish persistent colonization,exacerbate inflammation and trigger carcinogenesis. | Jennifer Raisch Emmanuel Buc Mathilde Bonnet Pierre Sauvanet Emilie Vazeille Amélie de Vallée Pierre Déchelotte Claude Darcha Denis Pezet Richard Bonnet Marie-Agnès Bringer Arlette Darfeuille-Michaud | 2014 | World Journal of Gastroenterology2014，20，21： | 12 |
| 3 | 外加应力对贝氏体相变组织形貌的影响显示文摘为揭示贝氏体相变机制及外加应力对它的影响,采用透射电镜研究了140MPa的外加拉应力对中碳低合金钢35MV7的450°C等温贝氏体相变组织形貌的影响.研究发现,由于外加应力的存在,贝氏体相变基元及其组成的铁素体条的尺寸变得非常粗大并形成多样的变态.这种尺寸的变化是由于外加应力产生额外的相变驱动力,使相变基元块可以克服更大的弹性应变能而长成更大的体积. | 苏铁健 李树奎 张朝晖 AEBY-GAUTIER E DENIS S BRIEN V | 2005 | 材料科学与工艺2005，13，3： | 3 |
| 4 | Factor analysis identifies subgroups of constipation显示文摘AIM:To determine whether distinct symptom groupings exist in a constipated population and whether such grouping might correlate with quantifiable pathophysiological measures of colonic dysfunction.METHODS:One hundred and ninety-one patients presenting to a Gastroenterology clinic with constipation and 32 constipated patients responding to a newspaper advertisement completed a 53-item,wide-ranging selfreport questionnaire.One hundred of these patients had colonic transit measured scintigraphically.Factor analysis determined whether constipation-related symptoms grouped into distinct aspects of symptomatology.Cluster analysis was used to determine whether indi-vidual patients naturally group into distinct subtypes.RESULTS:Cluster analysis yielded a 4 cluster solution with the presence or absence of pain and laxative unresponsiveness providing the main descriptors.Amongst all clusters there was a considerable proportion of patients with demonstrable delayed colon transit,irritable bowel syndrome positive criteria and regular stool frequency.The majority of patients with these characteristics also reported regular laxative use.CONCLUSION:Factor analysis identified four constipation subgroups,based on severity and laxative unresponsiveness,in a constipated population.However,clear stratification into clinically identifiable groups remains imprecise. | Philip G Dinning Mike Jones Linda Hunt Sergio E Fuentealba Jamshid Kalanter Denis W King David Z Lubowski Nicholas J Talley Ian J Cook | 2011 | World Journal of Gastroenterology2011，17，11： | 3 |
| 5 | Transformation kinetics and microstructures of Ti17 titanium alloy during continuous cooling显示文摘 | TEIXEIRA J APPOLAIRE B AEBY-GAUTIER E DENIS S CAILLETAUD G SPAAETH N | 2007 | Materials Science and Engineering A2007，448，12： | 1 |
| 6 | A knowledge--based system for non--destructive diagnostics of fa- cade isolation using the information fusion of visual and IR images 显示文摘 | Slobodan Ribari c Darijan Marceti e Denis Stjepan Vedrina | 2009 | Expert Systems with Applications2009，，36： | 1 |
| 7 | The three column spine and its significance in the classification of acute thoracolumbar spinal injuries显示文摘 | Denis E | 1983 | Spine1983，8，8： | 1 |
| 8 | Genetically engineered immunity to papaya ringspot virus in Australian papaya cultures显示文摘 | Rosemarie E L Denis P James L D | 2002 | Molecular Breeding2002，10，： | 1 |
| 9 | Synthesis and electrochemical properties of numerous classes of vanadates显示文摘 | Denis S Baudrin E Orsini F | 1999 | J Power Sources1999，8182，： | 1 |
| 10 | Policies and struc- tures for spinning off new companies from research and de- velopment organizations 显示文摘 | ROBERTS E B DENIS E MALONET | 1996 | R&D Management1996，26，： | 1 |
| 11 | Final results of the94-01 french head and neck oncology and radiotherapy group randomized trim comparing radiotherapy alone with concomitant radioch emotherapy in advanced stage oropharynx carcinoma 显示文摘 | Denis F Garand P Bardet E | 2004 | Clin Oncol2004，22，1： | 1 |
| 12 | Advanced screen printing technique for high definition front side metallization of crystal- line silicon cells 显示文摘 | Denis E Aleksander F Marc R | 2010 | Solar Energy Materials and Solar Cells2010，94，1： | 1 |
| 13 | 57Fe M ossbauer study of the electrochemical reaction of lithium with tri- clinic iron vanadate显示文摘 | Denis S Dedryvare R Baudrin E | 2000 | Chem Mater2000，12，： | 1 |
| 14 | Prospect, Perspective and the Evolution Landscape Idea显示文摘 | COSGROVE Denis E | 1985 | Transactions of the Institute of British geographers New Series1985，10，1： | 1 |
| 15 | Degenerative lumbar scoliosis associated with spinal stenosis 显示文摘 | Ploumis A Transfledt E E Denis F | 2007 | Spine2007，7，4： | 1 |
| 16 | Degenerative lumbar scoliosis associated with spinal stenosis显示文摘 | PLOUMIS A TRANSFLEDT E E DENIS F | 2007 | Spine Jour- nal2007，7，4： | 1 |
| 17 | Synthesis and electrochemical properties of numerous classes of vanadates 显示文摘 | DENIS S BAUDRIN E ORSINI F OUVRARD G TOUBOUL M TARSCOM J M | 1999 | J Power Sources1999，8182，： | 1 |
| 18 | Final results of the 94-01 French Head and Neck Oncology and Radiotherapy Group randomized trial comparing radiotherapy alone with concomitant radiochemotherapy in advanced-stage oropharynx carcinoma显示文摘 | Garaud P Bardet E | 2004 | J Clin Oncol2004，22，： | 1 |
| 19 | Stress-phase-transformation interactions-basic principles, modelling and calculation of internal stresses显示文摘 | Denis S Gautier E Simon A | 1985 | Mater Sci Technol1985，，1： | 1 |
| 20 | Saturated faTTy acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus:implications for the pathogenesis of obesity显示文摘 | Milanski M Degasperi G Coope A Morari J Denis R Cintra D E Tsukumo D M Anhe G | | 0，，02： | 1 |
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