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| 1 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 2 | Coronary artery disease in congenital single coronary artery in adults:A Dutch case series显示文摘AIM:To assess the current diagnostic and therapeutic management and the clinical implications of congenital single coronary artery(SCA) in adults.METHODS:We identified 15 patients with a SCA detected from four Dutch angiography centers in the period between 2010 and 2013.Symptomatic patients who underwent routine diagnostic coronary angiography(CAG) for suspected coronary artery disease and who incidentally were found to have isolated SCA were analyzed.RESULTS:Fifteen(7 females) with a mean age of 58.5 ± 13.78 years(range 43-86) had a SCA.ConventionalCAG demonstrated congenital isolated SCA originating as a single ostium from the right sinus of Valsalva in 6 patients and originating from the left in 9 patients.Minimal to moderate coronary atherosclerotic changes were found in 4,and severe stenotic lesions in another 4 patients.Seven patients were free of coronary atherosclerosis.Runs of non-sustained ventricular tachycardia were documented in 2 patients,one of whom demonstrated transmural ischemic changes on presentation.Myocardial perfusion scintigraphic evidence of transmural myocardial ischemia was found in 1 patient due to kinking and squeezing of the SCA with an interarterial course between the aorta and pulmonary artery.Multi-slice computed tomography(MSCT) was helpful to delineate the course of the anomalous artery relative to the aorta and pulmonary artery.Percutaneous coronary intervention was successfully performed in 3 patients.Eight patients were managed medically.Arterial bypass graft was performed in 4 patients with the squeezed SCA.CONCLUSION:SCA may be associated with transient transmural myocardial ischemia and aborted sudden death in the absence of coronary atherosclerosis.The availability and sophistication of MSCT facilitates the delineation of the course of a SCA.We present a Dutch case series and review of the literature. | Salah AM Said Willem G de Voogt Suat Bulut Jacques Han Peter Polak Rogier LG Nijhuis Jeroen W op den Akker Andries Slootweg | 2014 | World Journal of Cardiology2014，6，4： | 3 |
| 3 | Formation of polychlorinated benzenes during the catalytic combustion of chlorobenzene using a Pt/v-Al2O3 catalyst显示文摘 | R W von den Brink R Louw P Mulder | 1998 | Applied Catalysis B:Environmental1998，16，： | 2 |
| 4 | Efficiency estimation from cobb-douglas production functions with composed error显示文摘 | Meeusen W & J van den Broeck | 1977 | International Economic Review1977，18，2： | 2 |
| 5 | Postprandial blood hormone and metabolite concentrations influenced by feeding frequency and feeding level in veal calves显示文摘 | VICARI T VAN DEN BORNE J J G C GERRITS W J J | 2008 | Domestic Animal Endocrinology2008，34，： | 1 |
| 6 | Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion 显示文摘 | Le Poole IC van den Wijngaard RM Westerhof W | 1997 | Br J Dermatol1997，137，2： | 1 |
| 7 | Treatment of asperginosis:Clinical prcatice guidelines of the infectious diseases society of America显示文摘 | Walsh T J Anaissie E J Denning D W | 2008 | Clin Infect Dis2008，46，： | 1 |
| 8 | Experimental evidence for water weakening of quartzite by microcracldng plus solution-precipitation creep显示文摘 | Den Brok S W J Spiers C J | 1991 | Journal of Geologlcal Society1991，148，3： | 1 |
| 9 | Mutation in mitochondrion t-RNALeu(URR) gene in a large pedigree with mater- nally transmitted type II diabetes melitus and deafness 显示文摘 | Van den Ouweland JM Lemkes HH Ruitenbeek W | 1992 | Nat Genet1992，1，5： | 1 |
| 10 | Re cent sedimentation and sediment accumulation rates of the Ba Lat prodelta(Red River, Vietnam) 显示文摘 | van den Bergh G D Boer W Schaapveld M A S | 2007 | Journal of Asian Earth Sciences2007，，29： | 1 |
| 11 | Fructan ac-cumulation induced by nitrogen deficiency in barley leaves correlates with the level of sucrose: fructan 6-fruc-tosyltransferase mRN A显示文摘 | Wang C W Van den Ende W TillbergJ E | 2000 | Planta2000，211，： | 1 |
| 12 | Acceptance and long- term compliance of nCPAP in obstructive sleep apnea 显示文摘 | Richard W Venker J den Herder C | 2007 | Eur Arch Otorhinolaryngo12007，264，： | 1 |
| 13 | Recovery of selenium from copper anode slimes 显示文摘 | DUTTON W A van den STEEN A J THEMELIS N J | 1971 | Metallurgical Transactions1971，2，： | 1 |
| 14 | Effect of wheat cultivar and enzyme addition to broiler chicken diets on nutrient digestibility,performance,and apparent metabolizable energy content显示文摘 | Gutierrez del Alamo A Verstegen M W Den Hartog L A | 2008 | Poult Sci2008，87，4： | 1 |
| 15 | A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis显示文摘 | Robberecht W Aguirre T Van Den Bosch L | 1996 | Neurology1996，47，： | 1 |
| 16 | New and emerging treatments for fungal infections 显示文摘 | PASQUALOTTO A C DENNING D W | 2008 | J Antimicrob Chem2008，61，1： | 1 |
| 17 | A new model of diffuse brain injury in rat: part Ⅰ: pathophysiology and biomechanics 显示文摘 | Foda AAA van den Brink W | 1994 | J Neurosurg1994，80，： | 1 |
| 18 | Fluoro scopic positioning of sacroiliac serews in 88 patients显示文摘 | Van den Bosch E W Van Zwienen C M Van Vugt A B | 2002 | JTrauma2002，53，1： | 1 |
| 19 | Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of florfenicol显示文摘 | HILLAERT S van den BOSSCHE W | 2004 | Journal of Pharmaceutical and Biomedical Analysis2004，36，3： | 1 |
| 20 | Morphological and biochemical aspects of apoptosis, oncosis and necrosis 显示文摘 | Van Cruchten S Van Den Broeck W | 2002 | Anat Histol Embryol2002，31，4： | 1 |
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