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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico显示文摘 | Perez-Padilla R de la Rosa Zamboni D Ponce de Leon S | 2009 | N Engl J Med2009，361，7： | 1 |
| 3 | Nm23/nucleoside diphosphate kinase:toward a structural and biochemical understanding of its bio logical functions显示文摘 | de la Rosa A Williams R L Steeg P S | 1995 | Bioessays1995，17，1： | 1 |
| 4 | Parosteal lipoma of therib: CT findings and pathologic correlation 显示文摘 | Imbriaco M Ignarra R De Rosa N | 2003 | Clin Imaging2003，27，： | 1 |
| 5 | Secondary metabolites and nutrient concentra- tions in silver bitch seedling under five levels of daily UV-B exposure and two relative nutrient addition rates 显示文摘 | DE LA ROSA TM JULKUNEN-TIIT- TO R LEHTO T | 2001 | New Phytologist2001，150，1： | 1 |
| 6 | Graftversus-host disease,an eight case report and literature review 显示文摘 | de la Rosa Garcia E Bologna Molina R Vega Gonzflez Tde J | 2006 | Med Oral Patol Oral Cir Bucal2006，11，6： | 1 |
| 7 | A new mesophase of isotactic polypropylene in copolymers of propylene with long branched comonomers 显示文摘 | De Rosa C Auriemma F Di Girolamo R | 2010 | Macromolecules2010，43，20： | 1 |
| 8 | Role of nitric oxide in the functional response to ischemia reperfusion of heart mitochondria from hyperthyroid rats显示文摘 | Venditti P De Rosa R Cigliano L | 2004 | Cell Mol Life Sci2004，61，17： | 1 |
| 9 | Effect of thyroid state on H2O2 production by mt liver mitochondria 显示文摘 | Venditti P De Rosa R Di Meo S | 2003 | Mol Cell Endocrinol2003，205，12： | 1 |
| 10 | Interleukin-2 is essential for CD4^+ CD25^+ regulatory T cell function 显示文摘 | Maurus de la Rosa Sascha R Heike D | 2004 | Eur J Immunol2004，34，9： | 1 |
| 11 | Development ofEST-derived SSR markers with long-core repeat in olive and theiruse for paternity testing显示文摘 | De la Rosa R Belaj A Munoz-M6rida A | 2013 | Journal of the American Society forHorticultural Science2013，138，4： | 1 |
| 12 | On the inter-harmonics components generated by adjustable speed drives显示文摘 | De Rosa F Langella R Sollazzo A | 2005 | IEEE Trans on Power Delivery2005，20，4： | 1 |
| 13 | Myocardial expression of FOXO3a-Atrogin-1 pathway in human heart failure显示文摘 | Galasso G De Rosa R Piscione F | 2010 | Eur J Heart Fail2010，12，12： | 1 |
| 14 | Regulated recruitment of DC-SIGN to cell-cell contact regions during zymosan-induced human dendritic cell aggregation显示文摘 | Yanez MM Samaneigo R | 2005 | J Leukoc Biol2005，77，5： | 1 |
| 15 | Pneumonia and respiratory failure from swine origin influenzaA (H1N1) in Mexico显示文摘 | PerezPadilla R de la Rosa Zamboni D Ponce de Leon S etal | 2009 | N EnglJ Med2009，361，7： | 1 |
| 16 | Transcoronary Concentration Gradients of Circulating MicroRNAsClinical Perspective显示文摘 | De Rosa S Fichtlscherer S Lehmann R | 2011 | Circulat2011，124，18： | 1 |
| 17 | Pneumonia and respiratory failure from swine origin influenza A (H1N1) in Mexico显示文摘 | Perez- Padilla R de la Rosa - Zamboni D Ponce de Leon S | 2009 | N Engl J Med2009，361，7： | 1 |
| 18 | A convenient catalytic procedure for the highly enantioselective aldol condensation of O-silyldienolates显示文摘 | De Rosa M Acocella M R Villano R | 2003 | Tetrahedron: Asymmetry2003，14，： | 1 |
| 19 | Effects of the growth stage on the heavy metal tolerance of alfalfa plants显示文摘 | Peralta-Videa J R Rosa G de la Gonzalez J H | 2004 | Advances in Environmental Research2004，，8： | 1 |
| 20 | The role of the crust in the magmatic evolution of the island of Lipari (Aeolian Island, Italy) 显示文摘 | CRISCI G M de ROSA R | 1992 | Contrib Mineral Petrol1992，112，： | 1 |
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