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| 1 | 血栓形成的抗栓治疗和预防,第9版:美国胸科医师学院循证的临床实践指南显示文摘【缩写】ACS=急性冠脉综合征;AF=心房纤颤;AIS=动脉性缺血性卒中;APLA=抗磷脂抗体;ASA=阿司匹林;AT9=第9版血栓的抗栓治疗和预防:美国胸科医师学院循证的临床实践指南;BMS=裸金属支架;CABG=冠状动脉旁路移植术;CAD=冠状动脉疾病;CDT=导管接触溶栓;CHADS2=充血性心力衰竭,高血压,年龄≥75岁,糖尿病,有卒中或TIA病史; | 潘元美 曹雯炜 秦洁行 周洁茹 金海峰 朱莹 李焰生 Guyatt GH Akl EA Crowther M Gutterman DD Schu nemann HJ | 2012 | 神经病学与神经康复学杂志2012，9，1： | 195 |
| 2 | 全髋关节置换术全身麻醉与蛛网膜下腔阻滞麻醉的比较显示文摘全髋关节置换术(total hip arthroplasty,THA)被认为是目前最成功的骨科手术之一,全世界每年约有一百万例THA手术。全身麻醉一直是髋关节手术的金标准,但目前THA手术也常采用蛛网膜下腔阻滞麻醉(脊椎麻醉),最佳的麻醉方法一直存有争议。既往的几项研究显示,相较于全身麻醉,椎管内麻醉具有减少失血量和输血需求量、降低血栓栓塞发生率和手术部位感染率的优点,但这些结果大都来自于小样本、单一机构,缺乏直接比较THA全麻与脊椎麻醉围术期效果的大样本、多中心研究。 | Basques BA Toy JO Bohl DD 胡玮 | 2015 | 中国骨科临床与基础研究杂志2015，7，4： | 39 |
| 3 | 产ESBL大肠埃希菌和肺炎克雷伯菌导致的社区获得性血流感染在中国广泛流行显示文摘产ESBL大肠埃希菌(ESBL-EC)和肺炎克雷伯菌(ESBL-KP)导致的社区获得血流感染(COBSI)近年来在全球范围内均有增多。本研究旨在分析ESBL-EC和ESBL-KP导致COBSI的流行和危险因素。 | Quan JJ Zhao DD Liu LL 郝敏 林东昉 | 2017 | 中国感染与化疗杂志2017，17，3： | 29 |
| 4 | 肽酰基精氨酸脱亚氨酶4和中性粒细胞胞外诱捕网形成在实验性动脉粥样硬化和动脉损伤中的作用:浅表糜烂的影响显示文摘中性粒细胞可能促进人类动脉粥样硬化的血栓并发症的发生。特别是中性粒细胞胞外诱捕网(neutrophil extracellular traps,NETs)可加剧局部炎症,并放大和加剧动脉内膜损伤和血栓形成。肽酰基精氨酸脱亚氨酶4(peptidyl arginine deiminase 4,PAD4)参与NET的形成,但对该酶在动脉粥样硬化血栓形成中的作用的认识仍然不足。 | 刘青 叶鹏 Franck G Mawson TL Folco EJ Molinaro R Ruvkun V Engelbertsen D Liu X Tesmenitsky Y Shvartz F Sukhova GK Michel JB Nicoletti A Lichtman AH Wagner DD Croce KJ Libby P | 2018 | 中华高血压杂志2018，26，5： | 13 |
| 5 | 阿法骨化醇对去卵巢大鼠骨质疏松症防治作用的实验研究显示文摘目的 探讨从骨量、骨结构、骨力学和骨转换等方面研究阿法骨化醇对去卵巢大鼠骨质疏松症的防治作用。方法 5 3只健康雌性未交配 6个月龄Wistar大鼠分为 6组 (1)基线组 (Base) 6个月龄时处死 ;(2 )假手术组 (Sham) ;(3)去卵巢 (OVX)治疗前对照组 (OVXb) ;(4 )OVX治疗末对照组(OVXe) ;(5 )OVX后雌激素治疗组 (O +E) ;(6 )OVX后阿法骨化醇治疗组 (O +VD)OVX后 6周开始经胃肠给予阿法骨化醇每天 0 .1μg/kg ,共 8周。动物处死前留取 2 4h尿标本 ,处死时留取右侧胫骨、股骨和血标本。进行骨组织计量学动态和静态指标分析 ,计算机断层扫描 (pQCT)检查 ,股骨远端凹入实验和血尿骨转换指标测定。结果 O +VD的骨小梁面积较未治疗组增加l0 6 .7% (12 .0 %± 1.1%比 5 .8%± 1.3% ,P <0 .0 1)。pQCT检查表明 ,O +VD的股骨远端松质骨骨量和骨密度分别较OVXe增加 10 9.2 %和 133.1% ,P均 <0 .0 1。O +VD组的股骨远端松质骨的最大载荷较OVXe增加 170 .8%(2l.3%± 4.0 %比 7.9%± 1.9%P <0 .0 5 )。O +VD的尿脱氧吡啶啉较OVXe显著下降 (降低5 8 9% ,P <0 .0l)。结论 阿法骨化醇能使OVX骨质疏松症大鼠的骨量增加 ,骨小梁的结构改善 ,同时使松质骨的力学特性得以改善 。 | 夏维波 孟迅吾 邢小平 周学瀛 胡莹莹 Victor Shen DD WU | 2000 | 中华医学杂志2000，80，9： | 9 |
| 6 | Nitrite-derived nitric oxide by xanthine oxidoreductase protects the liver against ischemia- reperfusion injury显示文摘It was demonstrated that xanthine oxidoreductase (XOR), during ischemia, catalyzes the formation of nitric oxide (NO) from nitrite (NO2-) and this NO2--derived NO protects the isolated perfused rat heart against the damaging effects of ischemia-reperfusion (I/R) when conventional nitric oxide synthase (NOS) -dependent NO production is impaired. Liver is one of the organs with the highest XOR concentration. This study was designed to determine whether NO2--derived NO by XOR protects liver against I/R injury in vivo. For its minute amounts and active reactivity, NO can not be detected directly in real time in vivo by this time. We have to prove the above hypothesis indirectly. METHODS:Wistar rats were pretreated with saline, NOS inhibitor L-NAME (10 mg/kg intravenously), XOR inhibitor allopurinol (1.5 mg/kg orally), L-NAME +allopurinol and NO scavenger carboxy-PTIO (0.6 mg/kg intravenously) respectively (12 animals per group). And then, they were subjected to total liver ischemia for 40 minutes followed by reperfusion. Blood samples and liver tissues were obtained for analysis after 3 hours of reperfusion. Survival was also investigated. RESULTS:Allopurinol-treated animals exhibited further increased serum alanine aminotransferase (ALT) levels and liver myeloperoxidase (MPO) activities, but further decreased liver adenosine triphosphate (ATP) stores after I/R compared to saline-treated counterparts (830.5±108.3 U/L, 56.5±11.0 U/mg protein and 1.93±0.47 μmol/g vs. 505.8± 184.2 U/L, 41.5±10.2 U/mg protein and 3.05±0.55 μmol/g respectively, P<0.01, P<0.05 and P<0.01 respectively). The hepatocyte injury was further exacerbated and the overall survival rate was significantly decreased after I/R in animals given by allopurinol compared to those pretreated by saline (P<0.05). L-NAME and allopurinol co-treated animals exhibited more severe liver injury (P<0.05 and P<0.01) and a further decreased overall survival rate (P<0.05) compared to L-NAME or allopurinol alone-treated counterparts, but they were not different from carboxy-PTIO treated animals (P>0.05). CONCLUSION:NO2--derived NO by XOR in the hypoxic and acidic environment induced by hepatic I/R protects the liver against I/R injury in vivo. | Department of General Surgery ( Lu P, Wang CY and Chen DD), and Department of Radiology (Liu F), Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Cold Spring Harbor Laboratory, New York 11724, USA ( Yao Z) General Surgery Laboratory, Union Hospital, Tongji Medical College , Huazhong University of Science and Technology, Wuhan 430022 , China (Tian Y, Zhang JH and Wu YH) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 4 |
| 7 | 柳州市看护者教育水平与饮食方式对学前儿童缺铁的影响显示文摘缺铁是世界上营养失调的最常见原因,且是唯一在发展中国家和工业化国家都十分流行的营养缺乏现象[1]。当一个人的铁储量被耗尽且血红素形成减缓,就会出现缺铁。缺铁性贫血是铁耗尽的严重阶段,如果没有尽早治疗,缺铁性贫血会导致儿童出现许多临床并发症,包括不可逆的认知功能障碍[2]和教育成效不佳[3]。 | Magvanjav O Perkins DD Lilienthal GM Kopsombut UG 周丽芳 白娟 张永 | 2016 | 中国学校卫生2016，37，2： | 4 |
| 8 | ^(99m)Tc制剂作心肌灌注显像的生理学基础显示文摘近年来,人们对几种^(99m)Tc标记的心肌灌注显像剂进行了研究,以确定它们在评价局部心肌血流和细胞存活力的效果。由于极好的物理学特征,这些^(99m)Tc制剂可能比^(201)Tl更适合作心肌灌注显像。^(99m)Tc的能峰为140keV,适宜于γ照相成像,且成象质量比^(201)Tl高。^(99m)Tc半衰期短,更好的放射剂量测定使它的使用剂量可比铊大10~15倍。 | Beller GA Watson DD 曹亦洪 | 1993 | 国外医学(放射医学核医学分册)1993，17，4： | 3 |
| 9 | 6 儿童血管瘤的流行病学、影像学特征及治疗效果显示文摘对1998—2007年间收治的58例血管瘤患者进行回顾性研究,分析患者人口学资料、影像学特点、治疗方法及其结果。结果:男19例,女39例,64%的患者病变位于头颈部.3例合并卡-梅综合征.21例无影像学资料.37例行B超和(或)MRI检查,85%的患者B超为混合性回声。 | Rasalkar DD Chu WC Cheng FW | 2010 | 中国口腔颌面外科杂志2010，8，6： | 2 |
| 10 | 膳食硝酸盐通过减少交感神经过度激活的机制降低血管紧张素Ⅱ诱导的高血压大鼠的血压显示文摘几项实验和临床研究表明,膳食中添加硝酸盐可提高一氧化氮的生物利用度。在口腔中,共生细菌将硝酸盐还原成亚硝酸盐,其随后被吸收到循环中,通过酶系统还原为一氧化氮。已知增加硝酸盐-亚硝酸盐-一氧化氮途径可以改善心血管、肾脏和代谢功能,并且交感神经兴奋有助于疾病的进展,但是膳食硝酸盐对交感神经活动的潜在影响仍有待阐明。 | 刘莉 叶鹏 ■ DD Cruz JC ■ A Zhuge Z Marques SM Naves LM Persson AEG Weitzberg E Lundberg JO Balarini CM Pedrino GR Braga VA ■ M | 2019 | 中华高血压杂志2019，0，3： | 2 |
| 11 | Cerebral circulation in chronic arterial hypertension显示文摘 | Baumbach GL Heistad DD | 1988 | Hypertension1988，12，2： | 2 |
| 12 | 甘蔗产量的相关和通径分析显示文摘 | Main.,DD 邹宗兰 | 1993 | 国外农学(甘蔗)1993，，2： | 2 |
| 13 | Changing trends of surgical treatment of hilar bile duct cancer:clinical and experimental perspectives显示文摘HISTORICAL POINT OF VIEWCarcinoma of the confluence of the hepatic ductshas been thought to be a rare disease until recently.Carcinoma of the large hepatic ducts was rarelydiagnosed correctly premorterned.Because of itsdeeply seated location,resection was once thoughtto be impossible.In 1957,Altemeier reported | Huang ZQ Zhou NX Wang DD Lu JG Chen MY | 2000 | World Journal of Gastroenterology2000，6，6： | 2 |
| 14 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 15 | 地中海膳食干预研究中来自胆碱通路的血浆代谢物与心血管病风险的关系显示文摘血浆甜菜碱水平以及胆碱代谢水平与主要心血管病终点之间的联系仍不清楚。研究者评估了胆碱通路的代谢物与偶发心血管病风险以及地中海膳食干预的潜在调节效应之间的相关性。 | 黄洁 叶鹏 Guasch-Ferré M Hu FB Ruiz-Canela M Bulló M Toledo E Wang DD Corella D Gómez-Gracia E Fiol M Estruch R Lapetra J Fitó M Arós F Serra-Majem L Ros E Dennis C Liang L Clish CB Martínez-González MA Salas-Salvadó J | 2017 | 中华高血压杂志2017，25，12： | 2 |
| 16 | A case of acute epididymo-orchitis due to Pseudomonas aeruginosa presenting as ARDS in an immunocompetent host显示文摘Acute eididymo-orchitis is the most common cause of intrascrolal inflammation,and retrograde ascent of pathogens is the usual route of infection.Here we intend to present a case of young hoy. not sexually active,suffering from acute epididymo-orchitis due lo Pseudomonas aeruginosa presented with acute respiratory distress syndrome.Proper timely diagnosis of the primary cause and prompt treatment including support with nun invasive ventilation lead lo a favourable outcome in the same case. | Sameer Singhal DD Wagh Shivali Kashikar Yeshwant Lonkar | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 2 |
| 17 | Clinical experience with the effectiveness and tolerability of hylan G-F 20 in 1047 patients with osteoarthritis of the knee显示文摘 | Waddell DD Bricker D | | Journal of Knee Surgery0，，： | 2 |
| 18 | 在接受治疗的急性冠状动脉综合征患者中,肌钙蛋白峰值与长期缺血事件之间的关系显示文摘非ST段抬高急性冠状动脉综合征(acutecoro-narysyndromes,ACS)患者肌钙蛋白水平与结局的关系虽然已经明确,但接受抗血小板治疗管理的非ST段抬高ACS患者肌钙蛋白水平与长期结局的关系尚未明确。 | 刘莉 叶鹏 Goldstein SA Newby LK Cyr DD Neely M Lüscher TF Brown EB White HD Ohman EM Roe MT Hamm CW | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 19 | Hylan G-F 20 tolerability with repeat treatment in a large orthopedic practice:a retrospective review显示文摘 | Waddell DD Bricker DC | | Journal of Surgical Orthopaedic Advance0，，： | 2 |
| 20 | Long-term prognosis of patients with variant angina 显示文摘 | Walling A Waters DD Miler D | 1987 | Circulation1987，76，： | 2 |
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