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| 1 | 血管内超声去肾交感神经术治疗高血压:一项多中心,国际,单盲,随机,假手术对照试验显示文摘早期研究表明,基于射频的去肾交感神经术可降低中度高血压患者的血压。研究者研究了在没有使用抗高血压药物的情况下,使用血管内超声去。肾交感神经术是否会降低高血压患者的动态血压。 | 刘青 叶鹏 Azizi M Schmieder RE Mahfoud F Weber MA Daemen J Davies J Basile J Kirtane AJ Wang Y Lobo MD Saxena M Feyz L Rader F Lurz P Sayer J Sapoval M Levy T Sanghvi K Abraham J Sharp ASP Fisher NDL Bloch MJ Reeve-Stoffer H Coleman L Mullin C Mauri L | 2018 | 中华高血压杂志2018，26，10： | 27 |
| 2 | Oedema and glial cell involvement in the aged mouse brain after permanent focal ischaemia显示文摘 | Fotheringham A P Davies C A Davies I | 2000 | Neuropathol Appl Neurobiol2000，26，5： | 4 |
| 3 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 4 | Relation of cerebral vasospasm to subaraclmoid hemorrhage visualized by computerized to mographic scanning显示文摘 | FISHER C M KISTLER J P DAVIS J M | 1980 | Neurosurgery1980，6，： | 1 |
| 5 | Electromagnetic determination of soil water content: measurement in coaxial transmission lines显示文摘 | Topp G C Davis J L Annan A P | 1980 | Water Resources Research1980，16，3： | 1 |
| 6 | Bioretention column studies of phosphorus removal from urban storm water runoff显示文摘 | Hsieh C H Davis A P Needleman B A | 2007 | Water Environ Res2007，79，2： | 1 |
| 7 | Mutations of the BRAF gene in human cancer显示文摘 | Davies H Bignell G R Cox C Stephens P Edkins S Clegg S et al | 2002 | Nature2002，417，： | 1 |
| 8 | Two new mechanisims of macrolide resistace in clinical mains of Streptococcus pneumoniase from Eastern Europe and North America 显示文摘 | Tait-Kamradt A Davies T A ppebatun P C | 2000 | Antimitrob Agents Chemother2000，44，11： | 1 |
| 9 | Canine tumor cross-species genomics uncovers targets linked to osteosarcoma progression显示文摘 | Paoloni M Davis S Lana S Withrow S Sangiorgi L Picci P Hewitt S Triche T Meltzer P Khanna C | | 0，，： | 1 |
| 10 | Exercise and children's intelligence, cognition, and academic achievement 显示文摘 | TOMPOROWSKI P D DAVIS C L NAGLIERI J A | 2008 | Edu Psychol Rev2008，20，2： | 1 |
| 11 | Application of the Australian river bioassessmentsystem ( AUSRIVAS) in the Brantas River, East Java,Indonesia 显示文摘 | Hart B T Davies P E Humphrey C L | | Journal of Environmental Management0，，： | 1 |
| 12 | A computer simulation of multi-ship encounters显示文摘 | DAVIS P V DOVE M J STOCKEL C T | 1982 | Journal of Navigation1982，35，： | 1 |
| 13 | Evidence for the presence of a major gene influencing ovulation rate on the X chromosome of sheep显示文摘 | Davis G H McEwan J C Fennessy P F | 1991 | Biol Reprod1991，44，4： | 1 |
| 14 | Modern management of cancerOrelat2ed intestinal obstruction显示文摘 | Davis M P Nouneh C | 2001 | Curr Pain Headache Rep2001，5，3： | 1 |
| 15 | Multiple-event study of bioretention for treatment of urban storm water runoff显示文摘 | Hsieh C H Davis A P | 2005 | Water Sci Technol2005，51，34： | 1 |
| 16 | Electromagnetic determination of soil water content:measurements in coaxial transmission lines显示文摘 | TOPP G C DAVIS J L ANNAN A P | 1980 | Water Resources Research1980，16，3： | 1 |
| 17 | A Kalman filter clock algorithm for use in the presence of flicker frequency modulation noise显示文摘 | Davis J A Greenhall C A Stacey P W | 2005 | Metrologia2005，42，1： | 1 |
| 18 | Transverse response of underground cavities and pipes to incident SV waves显示文摘 | Davis C A Lee V W Bardet J P | 2001 | Earthquake Engineering and Structural Dynamics2001，30，： | 1 |
| 19 | Treatment of grape berries,a noncli- maeterie fruit with a synthetic auxin, retards ripening and alters the expres- sion of developmentally regulated genes显示文摘 | Davies C Boss P K Robinson S P | | Plant Physiology0，115，3： | 1 |
| 20 | Starch damage part 1 : Characterization of granule damage in ball-milled potato starch study by SEM 显示文摘 | Baldwin P M Adler J Davies M C | 1995 | Starch1995，47，： | 1 |
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