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| 1 | Alcoholic pancreatitis:New insights into the pathogenesisand treatment显示文摘Acute pancreatitis is a necro-inflammatory disease of the exocrine pancreas that is characterized by inappropriate activation of zymogens, infiltration of the pancreas by inflammatory cells, and destruction of the pancreatic exocrine cells. Acute pancreatitis can progress to a severe life-threatening disease. Currently there is no pharmacotherapy to prevent or treat acute pancreatitis. One of the more common factors associated with acute pancreatitis is alcohol abuse. Although commonly associated with pancreatitis alcohol alone is unable to cause pancreatitis. Instead, it appears that alcohol and its metabolic by-products predispose the pancreas to damage from agents that normally do not cause pancreatitis, or to more severe disease from agents that normally cause mild pancreatic damage. Over the last 10 to 20 years, a tremendous amount of work has defined a number of alcohol-mediated biochemical changes in pancreatic cells. Among these changes are: Sustained levels of intracellular calcium, activation of the mitochondrial permeability transition pore, endoplasmic reticulum stress, impairment in autophagy, alteration in the activity of transcriptional activators, and colocalization of lysosomal and pancreatic digestive enzymes. Elucidation of these changes has led to a deeper understanding of the mechanisms by which ethanol predisposes acinar cells to damage. This greater understanding has revealed a number of promising targets for therapeutic intervention. It is hoped that further investigation of these targets will lead to the development of pharmacotherapy that is effective in treating and preventing the progression of acute pancreatitis. | Dahn L Clemens Katrina J Schneider Christopher K Arkfeld Jaclyn R Grode Mark A Wells Shailender Singh | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 10 |
| 2 | Alcoholic pancreatitis:Lessons from the liver显示文摘The association between alcohol consumption and pancreatitis has been recognized for over 100 years. Despite the fact that this association is well recognized, the mechanisms by which alcohol abuse leads to pancreatic tissue damage are not entirely clear. Alcohol abuse is the major factor associated with pancreatitis in the Western world. Interestingly, although most cases of chronic pancreatitis and many cases of acute pancreatitis are associated with alcohol abuse, only a small percentage of individuals who abuse alcohol develop this disease. This situation is reminiscent of the association between alcohol abuse and the incidence of alcoholic liver disease. The liver and the pancreas are developmentally very closely related. Even though these two organs are quite different, they exhibit a number of general structural and functional similarities. Furthermore, the diseases mediated by alcohol abuse in these organs exhibit some striking similarities. The diseases in both organs are characterized by parenchymal cell damage, activation of stellate cells, aberrant wound healing, and fibrosis. Because of the similarities between the liver and the pancreas, and the alcohol-associated diseases of these organs, we may be able to apply much of the knowledge that we have gained regarding the effects of alcohol on the liver to the pancreas. | Dahn L Clemens Katrina J Mahan | 2010 | World Journal of Gastroenterology2010，16，11： | 5 |
| 3 | Electrochemical and in situ X-ray diffraction studies of the reaction of lithium with tin oxide composites显示文摘 | COURTNEY I A DAHN J R | 1997 | J Electrochem Soc1997，144，： | 2 |
| 4 | Structure and electrochemistry of LiMO2 ( M = Ti, Mn, Fe, Co, Ni ) prepared by mechanochemical synthesis 显示文摘 | OBROVAC M N MAO O DAHN J R | 1998 | Solid State Ionics1998，，112： | 2 |
| 5 | High omega arachidonic acid/docosahexaenoic acid ratio induces mitochondrial dysfunction and altered lipid metabolism in human hepatoma cells显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD) is a common cause of liver disease worldwide and is a growing epidemic. A high ratio of omega-6 fatty acids to omega-3 fatty acids in the diet has been implicated in the development of NAFLD. However, the inflicted cellular pathology remains unknown. A high ratio may promote lipogenic pathways and contribute to reactive oxygen species(ROS)-mediated damage, perhaps leading to mitochondrial dysfunction.Therefore, these parameters were investigated to understand their contribution to NAFLD development.AIM To examine the effect of increasing ratios of omega-6:3 fatty acids on mitochondrial function and lipid metabolism mediators.METHODS Hep G2-derived VL-17 A cells were treated with normal(1:1, 4:1) and high(15:1,25:1) ratios of omega-6: omega-3 fatty acids [arachidonic acid(AA):docosahexaenoic acid(DHA)] at various time points. Mitochondrial activity and function were examined via MTT assay and Seahorse XF24 analyzer, respectively.Triglyceride accumulation was determined by using Enzy Chrom? and levels of ROS were measured by fluorescence intensity. Protein expression of the mediators of lipogenic, lipolytic and endocannabinoid pathways was assessed by Western blotting.RESULTS High AA:DHA ratio decreased mitochondrial activity(P < 0.01;up to 80%) and promoted intracellular triglyceride accumulation(P < 0.05;40%-70%).Mechanistically, it altered the mediators of lipid metabolism;increased the expression of stearoyl-Co A desaturase(P < 0.05;22%-35%), decreased the expression of peroxisome proliferator-activated receptor-alpha(P < 0.05;30%-40%) and increased the expression of cannabinoid receptor 1(P < 0.05;31%).Furthermore, the high ratio increased ROS production(P < 0.01;74%-115%) and reduced mitochondrial respiratory functions such as basal and maximal respiration, ATP production, spare respiratory capacity and proton leak(P < 0.01;35%-68%).CONCLUSION High AA:DHA ratio induced triglyceride accumulation, increased oxidative stress and disrupted mitochondrial functions. Stimulation of lipogenic and steroidal transcription factors may partly mediate these effects and contribute to NAFLD development. | Reem Ghazali Kosha J Mehta SW Annie Bligh Ihab Tewfik Dahn Clemens Vinood B Patel | 2020 | World Journal of Hepatology2020，12，3： | 2 |
| 6 | Study of irreversible capacities for Li insertion in hard and graphitic carbons显示文摘 | Xing W Dahn J R | 1997 | J Electrochemical Society1997，144，4： | 1 |
| 7 | 显示文摘 | Luo W B Dahn J R | 2009 | Electrochimica Acta2009，54，： | 1 |
| 8 | Studies of the Layered Manganese Bronzes, Na2/3 O2 with M = Co, Ni, Li and Li2/2 O2 Prepared by Ion-exchange 显示文摘 | J M Paulsen J R Dahn | 1999 | Solid State Ionics1999，126，1： | 1 |
| 9 | Reducing carbon in LiFePO4/C composite electrodes to maximize specific energy, volumetric energy, and tap density显示文摘 | Chen Z Dahn J R | 2002 | J Electrochem Soc2002，149，： | 1 |
| 10 | 17O NMR Spectra of Carbonyl Compounds ArCOX:Influence of Groups X on the Polarity of the Carbonyl Group 显示文摘 | Dahn H Pechy P Toan V V | 1997 | Magn Reson Chem1997，35，9： | 1 |
| 11 | Reducing carbon in LiFePO4/C composite electrodes to maxing specific energy, volumetric energy, and tap density 显示文摘 | Zhaohui C Dahn J R | 2002 | Journal of the Electrochemical Society2002，149，9： | 1 |
| 12 | Layered LiO2 cathode materials for lithium-ion batteries显示文摘 | Lu Zhonghua MacNeil D D Dahn J R | 2001 | Electrochemical and Solid State Lett2001，4，11： | 1 |
| 13 | Structure and electrochemistry of Li (NixCo1-2xMnx) O2 (0 ≤ x≤ 1/2)显示文摘 | Macneil D D Lu Z Dahn J R | 2002 | Electrochemical Soc2002，149，10： | 1 |
| 14 | The effect of boron substitution in carbon on the intercalation of lithium in Lix (B2C1-x )6 显示文摘 | Way B M Dahn J R | 1994 | J Electrochem Soc1994，141，4： | 1 |
| 15 | Li-insertion in hard carbon anode materials for Li-ion batteries 显示文摘 | BUIEL E DAHN J R | 1999 | Electrochim Acta1999，45，： | 1 |
| 16 | A new layered cathode material for rechargeable lithium batteries显示文摘 | Paulsen J M Larcher D Dahn J R | 2000 | J Electrochem Soc2000，147，8： | 1 |
| 17 | Thermal stability of LixCoO2,LixNiO2 and LixMnO2 and consequences for the safety of Li-ion cells显示文摘 | DAHN J R FULLER E W OBROVAC M | 1994 | Solid State Ionics1994，69，： | 1 |
| 18 | Trigonometric parallaxes of planetary-nebulae显示文摘 | HARRIS H C DAHN C C MONET D G | 1997 | IAU Syrup1997，180，： | 1 |
| 19 | Mechanically alloyed Sn-Fe(-C) powders as anode materials for Li-ion batteries--The SnFe2 SnFe3C active/inactive system 显示文摘 | Mao O Dahn J R | 1999 | Journal of the Electrochemical Society1999，146，2： | 1 |
| 20 | Structure and electro- chemistry of the spinel oxides LiTi204 and Li4~TisaO4显示文摘 | COLBOW K M DAHN J R HAERING R R | 1989 | J Power Sources1989，，26： | 1 |
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