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| 1 | Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales显示文摘BACKGROUND Seeking potentially novel blood markers of liver fibrosis and steatosis is constantly of crucial importance.Despite a growing number of studies in this field of hepatology,a certain role of hematological indices in the course of liver disorders has not been fully elucidated,yet.AIM To evaluate a diagnostic accuracy of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and mean platelet volume-to-platelet-ratio(MPR)in the course of alcoholic liver cirrhosis(ALC)and nonalcoholic fatty liver disease(NAFLD).METHODS One hundred forty-two patients with ALC,92 with NAFLD and 68 persons in control group were enrolled in the study.Hematological indices(NLR,PLR and MPR),indirect and direct markers of liver fibrosis(aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index,fibrosis-4,gamma-glutamyl transpeptidase to platelet ratio,procollagen Ⅰ carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,platelet-derived growth factor AB,laminin)were measured in each person.Model for end-stage liver disease(MELD)score in ALC group and NAFLD fibrosis score together with BARD score were calculated in NAFLD patients.Receiver operating characteristic(ROC)curves and area under the curve(AUC)values were applied to assess the sensitivity and specificity of examined markers and to evaluate proposed cut-offs of measured indices in the course of ALC and NAFLD.RESULTS MPR and NLR values in ALC patients were significantly higher in comparison to control group;PLR level was significantly lower.MPR and PLR correlated with assessed indirect and direct markers of liver fibrosis.MPR,NLR and PLR correlated with MELD score.NLR level in NAFLD patients was significantly higher in comparison to controls.MPR correlated with indirect markers of liver fibrosis and NAFLD fibrosis score.AUC values and proposed cut-offs for NLR,PLR and MPR in ALC patients were:0.821(>2.227),0.675(<70.445)and 0.929(>0.048),respectively.AUC values and proposed cut-offs for NLR,PLR and MPR in NAFLD group were:0.725(>2.034),0.528(>97.101)and 0.547(>0.038),respectively.CONCLUSION Hematological markers are inseparably connected with serological indices of liver fibrosis in ALC and NAFLD patients.MPR and NLR turned out to be the most powerful parameters in ALC patients. | Agata Michalak Halina Cichoz-Lach Malgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Andrzej Stepulak | 2020 | World Journal of Gastroenterology2020，26，47： | 6 |
| 2 | Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease显示文摘BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth exploring.There are still plenty of unresolved issues related to the actual role of hematological indices as potential markers of liver function.AIM To study red blood cell distribution width(RDW),RDW-to-platelet ratio(RPR)and RDW-to-lymphocyte ratio(RLR) in alcohol-related liver cirrhosis(ALC) and metabolic-associated fatty liver disease(MAFLD).METHODS The study group was composed of 302 people:142 patients with ALC and 92 with MAFLD;68 persons were included as controls.RDW,RPR and RLR were measured in each person.Indirect and direct parameters of liver fibrosis were also assessed [aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index(APRI),fibrosis-4(FIB-4),gamma-glutamyl transpeptidase to platelet ratio(GPR),procollagen I carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,plateletderived growth factor AB,laminin].MELD score in ALC patients and nonalcoholic fatty liver disease(NAFLD) fibrosis score together with BARD score were obtained in the MAFLD group.The achieved results were compared to controls.Then a correlation between assessed markers was done.Diagnostic value of each investigated parameter and its suggested cut-off in the research group RESULTS RDW,RPR and RLR values turned out to be significantly higher in ALC and MAFLD groups compared to controls(ALC:P<0.0001;NAFLD:P<0.05,P<0.0001 and P<0.0001,respectively).RPR correlated positively with MELD score(P<0.01) and indirect indices of liver fibrosis(FIB-4 and GPR;P<0.0001) in ALC patients;negative correlations were found between PDGF-AB and both:RDW and RPR(P<0.01 and P<0.0001,respectively).RPR correlated positively with NAFLD fibrosis score and APRI(P<0.0001) in the MAFLD group;a positive relationship was observed between RDW and FIB-4,too(P<0.05).AUC values and suggested cut-offs for RDW,RPR and RLR in ALC patients were:0.912(>14.2%),0.965(>0.075) and 0.914(>8.684),respectively.AUC values and suggested cut-offs for RDW,RPR and RLR in MAFLD patients were:0.606(>12.8%),0.724(>0.047) and 0.691(>6.25),respectively.CONCLUSION RDW with its derivatives appear to be valuable diagnostic markers in patients with ALC.They can also be associated with a deterioration of liver function in this group. | Agata Michalak Małgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Tomasz Lach Halina Cichoż-Lach | 2022 | World Journal of Gastroenterology2022，28，38： | 4 |
| 3 | Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner显示文摘遇到 hypoxic 应力的房间由 downregulating 保存资源和精力蛋白质合成。这里我们 demonstratethat 在这回答的一机制是最高的 mRNAs 的翻译压抑编码 translationalapparatus 的部件。规定的这个模式包含 TSC 和 Rheb,当 Rheb 的 TSC1 或 TSC2 或 overexpression 的大美人在剥夺氧的房间救了最高的 mRNA 翻译。导致压力的翻译 repressionof 这些 mRNAs 密切与 4E-BP 的 hypophosphorylated 状态相关,一个翻译抑压者。然而, seriesof 4E-BP loss-of-function 和 gain-of-function 实验在氧或生长因素剥夺下面反驳在 phosphorylation statusof 4E-BP 和最高的 mRNAs 的翻译压抑之间的一种 cause-and-effect 关系。而且,血缺氧的 repressiveeffect 类似于由 Torin 1,而是更多 pronouncedthan 猛禽或 rictor 大美人由 mTOR 活动的有效抑制到达了那。同样,猛禽或 rictor 的缺乏它温和地 downregulated TOPmRNAs 的基础翻译效率,没能压制最高的 mRNAs 的调停氧的翻译激活。最后, TIA-1 和 TIAR co 击倒,二 RNA 有约束力的蛋白质以前在氨基的酸饥饿的房间在最高的 mRNAs 的翻译压抑含有, failedto 在另外的压力条件下面减轻最高的 mRNA 翻译。因此,近似翻译管理者 ofTOP mRNAs 的性质留下逃犯。 | Rachel Miloslavski Elad Cohen Adam Avraham Yifat I luz Zvi Hayouka Judith Kasir Rajini Mudhasani Stephen N. Jones Nadine Cybulski Markus A. Ruegg Ola Larsson Valentina Gandin Arjuna Rajakumar Ivan Topisirovic Oded Meyuhas | 2014 | Journal of Molecular Cell Biology2014，8，3： | 3 |
| 4 | NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?显示文摘 | Cllins T Cybulsky MI | 2001 | J Clin Invest2001，107，3： | 2 |
| 5 | 显示文摘 | Cybulski Andrzej Moulijn Jacob A | 1994 | Catalysis Review-Science Engineering1994，36，2： | 2 |
| 6 | Complement C5b-9 membrane attack complex increases expression of endoplasmic reticulum stress proteins in glomerular epithelial cells 显示文摘 | Cybulsky AV Takano T Papillon J | 2002 | Biol Chem2002，277，41： | 1 |
| 7 | Endoplasmic reticulum stress in proteinuric kidneydisease显示文摘 | Cybulsky AV | 2010 | Kidney Intemaional2010，77，3： | 1 |
| 8 | NF--kappaB: pivotal mediator or innocent bystander in atherogenesis? 显示文摘 | Collins T Cybulsky MI | 2001 | J Clin Invest2001，107，3： | 1 |
| 9 | CHEK2 is a muhiorgan cancer susceptibility gene显示文摘 | Cybulski C Gorski B Huzarski T | 2004 | Am J Hum Genet2004，75，6： | 1 |
| 10 | Acute inflammation and microthrombosis induced by endotoxin interleukin-1 and tumor necrosis factor and their implication in gram-negative infection显示文摘 | Cybulsky MI Chan MK Movat HZ | 1998 | Lab Invest1998，58，4： | 1 |
| 11 | Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury 显示文摘 | Cybulsky AV Takano T Papillon J | 2005 | Biol Chem2005，280，24： | 1 |
| 12 | Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and with rabbit atheroma显示文摘 | Li H Cybulsky MI Gimbrone MA Jr | 1993 | Am J Pathol1993，143，6： | 1 |
| 13 | NBS1 is a prostate cancer sus- ceptibility gene显示文摘 | Cybulski C G6rski B Debniak T | 2004 | Cancer Res2004，64，4： | 1 |
| 14 | Gettingto the site of inflammation,the leukocyte adhesioncascade updated显示文摘 | LEY K LAUDANNA C CYBULSKY M I | | 0，，09： | 1 |
| 15 | Endoplasmic reticulum stress in proteinuric kidney disease显示文摘 | Cybulsky AV | 2010 | Kidney Int2010，77，3： | 1 |
| 16 | A major role for VCAM - 1 ,but not ICAM - 1, in early atherosclerosis显示文摘 | Cybulsky MI liyama K Li H | 2001 | J Clin Invest2001，107，10： | 1 |
| 17 | A major role for VCAM-1, but not ICAM-1, in early atherosclerosis 显示文摘 | Cybulsky MI Iiyama K Li H | 2001 | J Clin Invest2001，107，： | 1 |
| 18 | An atherogenic diet rapidly induces VCAM-1,a cytokine-regulatable mononuclear leukocyte adhesion molecule,in rabbit aortic endothelium 显示文摘 | MI Cybulsky MA Gimbrone Jr and P Libby | 1993 | Arterioscler Thromb Vasc Biol1993，13，： | 1 |
| 19 | Lysophosphatidylcholine,a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells显示文摘 | Kume N Cybulsky MI Gimbrone MA | 1992 | J Clin Invest1992，90，： | 1 |
| 20 | Prospective e- valuation of alcohol consumption and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers 显示文摘 | Cybulski C Lubinski J Huzarski T et a/ | 2015 | Breast Cancer Res Treat2015，151，2： | 1 |
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