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| 1 | 哮喘治疗的新进展显示文摘没有强有力的循证医学证据表明饮食方法或Buteyko技术对哮喘的临床管理有很大益处需要进一步研究确定当哮喘控制欠佳时患者应该怎么做小剂量吸入皮质激素可以和长效β2激动剂联合应用,以提供安全有效的哮喘控制静脉镁制剂和白三烯受体拮抗剂对急性哮喘可能具有一些作用,但仍需进一步评价将来哮喘治疗是否能得到炎症生物标志或患者基因型认识的帮助。 | Graeme P Currie Graham S Devereux Daniel K C Lee Jon G Ayres 刘艳(译) 代华平(校) | 2005 | 英国医学杂志中文版2005，8，4： | 3 |
| 2 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 3 | 慢性阻塞性肺疾病知识(一) 诊断显示文摘和其他常见的疾病一样,慢性阻塞性肺疾病(COPD)的诊断依靠相关病史和适当的检查。确诊的客观证据依靠呼吸功能测量。对于35岁以上,有吸烟史及相关呼吸道症状的患者,医生应考虑到COPD的可能。 | Graeme P Currie Joe S Legge 陈奇 | 2007 | 英国医学杂志中文版2007，10，1： | 3 |
| 4 | Effects of earthworms on biomass production,nitrogen allocation and nitrogen transfer in wheat-clover intercropping model systems显示文摘 | Schmidt O Curry J P | 1999 | Plant and Soil1999，214，： | 1 |
| 5 | Exploring the Supply - side of IT Outsourcing: Evaluating the Emerging Role of Application Service Providers 显示文摘 | Currie WL Sehsikas P | 2001 | European Journal of Information Systems2001，10，12： | 1 |
| 6 | Palaeontology, sedimentology and palaeoecology of the Iren Dabasu Formation (Upper Creta- ceous) ,Inner Mongolia, People's Republic of China显示文摘 | Currie P J Eberth D A | 1993 | Creta- ceous research1993，14，2： | 1 |
| 7 | The Dempster-Shafer theory of evidence: an alternative approach to multicriteria decision modeling 显示文摘 | M Beynon B Curry P Morgan | 2000 | Omega2000，28，： | 1 |
| 8 | The short form of the alternatively spliced flt-4 but not its ligand vascular endothelial growth factoa C is related to lymph node mestasis in homan breast cancer显示文摘 | Gunningham S P Currie M J Han C | 2000 | Clin Cancer Res2000，6，11： | 1 |
| 9 | Modulation of North Pa- cific tropical cyclone activity by three phases of ENSO 显示文摘 | KIM H M WEBSTER P J CURRY J A | 2011 | Jour- nal of Climate2011，24，6： | 1 |
| 10 | Grassland Invertebrates: ecology, influence on soil fertility, and effects on plant growth 显示文摘 | Curry J P | 1994 | Chapman and Hall1994，437，： | 1 |
| 11 | Delivering Business Critical Information Systems though Application Service Providers -The Need for a Market Segmentation Strategy 显示文摘 | Currie WL Sehsikas P | 2001 | International Journal of Innovation Management2001，5，3： | 1 |
| 12 | Calculated optimal cooling rates for ram and human sperm cryopreservation fail to conform with empircal observations 显示文摘 | Curry M R Millar J D Watson P F | 1994 | Biol Reprod1994，51，： | 1 |
| 13 | Delivering Enterprise Resource Planning Systems through Application Service Providers 显示文摘 | Ekanayake Y Currie WL Seltsikas P | 2002 | Logistics Information Management2002，15，3： | 1 |
| 14 | Chicken-sized oviraptoric dinosaurs from central China and their ontogeneticimplications 显示文摘 | Lti J Currie P J Xu L | 2013 | Natursissenschaften2013，100，2： | 1 |
| 15 | Molecular aspects of iron up- take and storage in ferritin 显示文摘 | Curry P M P Chasteen N D | 1995 | Coordination Chemistry Reviews1995，144，： | 1 |
| 16 | MART-1 is expressed less frequently on circulating melanoma cells in patients who develop distant compared with locoregional metastases显示文摘 | Myers K Hersey P | 1999 | J Clin Oncol1999，17，8： | 1 |
| 17 | The Dempster-Shafer theory of evidence : an alternative approach to multicriteria decision model- ing 显示文摘 | Beynon M Curry B Morgan P | 2000 | The International Journal of Management Science2000，28，： | 1 |
| 18 | The angiogenic switch for vascular endothelial growth factor (VEGF)-A,VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression显示文摘 | Hanrahan V Currie M J Gunningham S P | 2003 | J Pathol2003，200，2： | 1 |
| 19 | Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility,Ca^2+ sensitivity and SERCA-2 in rat after myocardial infarction显示文摘 | Wisloff U Loennechen J P Currie S | 2002 | Cardiovasc Res2002，54，1： | 1 |
| 20 | Changes in tropical cyclone number, duration, and intensity in a warming environment 显示文摘 | WEBSTER P J HOLLAND G J CURRY J A | 2005 | Science2005，309，： | 1 |
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