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| 1 | 罕札族人的长寿之谜显示文摘巴基斯坦的罕札族人素有"世界上最健康的部族"之称,他们长寿的秘密也让许多科学家无从解释。有人认为是他们常年食素的原因,也有说法是他们的其他饮食习惯所致。不过真正让他们长寿的原因远没那么简单,在人类学家LászlóCsáji看来,"大多数罕札人都与巫术和灵性世界有连接,他们的世界里充满精灵、鬼魂、灵性帮手,对他们来说,在日常生活中它们就显而易见,而且充满了方方面面。在罕札,几乎每个人都懂得一些法术力量。"或许这就是秘密所在。 | 他者others László Csáji Human of Hunza | 2017 | 人与自然2017，0，9： | 0 |
| 2 | Exploring the mobility of mobile phone users显示文摘 | Balázs Cs. Csáji Arnaud Browet V.A. Traag Jean-Charles Delvenne Etienne Huens Paul Van Dooren Zbigniew Smoreda Vincent D. Blondel | 2012 | Physica A: Statistical Mechanics and its Applications2012，，： | 1 |
| 3 | An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways显示文摘Increasing evidence suggests that the use of potent neuroprotective agents featured with novel pharmacological mechanism would offer a promising strategy to delay or prevent the progression of neurodegeneration.Here,we provide the first demonstration that the chiral nonracemic isochroman-2H-chromene conjugate JE-133,a novel synthetic 1,3-disubstituted isochroman derivative,possesses superior neuroprotective effect against oxidative injuries.Pretreatment with JE-133(1–10μM)concentration-dependently prevented H2O2-induced cell death in SH-SY5Y neuroblastoma cells and rat primary cortical neurons.Pretreatment with JE-133 significantly alleviated H2O2-induced apoptotic changes.These protective effects could not be simply attributed to the direct free radical scavenging as JE-133 had moderate activity in reducing DPPH free radical.Further study revealed that pretreatment with JE-133(10μM)significantly decreased the phosphorylation of MAPK pathway proteins,especially ERK and P38,in the neuronal cells.In addition,blocking PI3K/Akt pathway using LY294002 partially counteracted the cell viability-enhancing effect of JE-133.We conclude that JE-133 exerts neuroprotection associated with dual regulative mechanisms and consequently activating cell survival and inhibiting apoptotic changes,which may provide important clues for the development of effective neuroprotective drug lead/candidate. | Ling-xue Tao Sha-sha Ji Dóra Szalóki Tibor Kovács Attila Mándi Sándor Antus Xun Ding Tibor Kurtán Hai-yan Zhang | 2021 | Acta Pharmacologica Sinica2021，42，1： | 0 |
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