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| 1 | 三电平和两电平逆变器效率分析与比较显示文摘在分析、计算二极管箝位型三电平逆变器和两电平逆变器的通态损耗、开关损耗以及输出滤波电感损耗的基础上,对这两种逆变器的损耗、效率进行了比较。 | Boris L Corral Martinez 马柯 李睿 徐德鸿 | 2009 | 电力电子技术2009，43，7： | 25 |
| 2 | Innate immune signaling and regulation in cancer immunotherapy显示文摘先存在的 T 煽动房间的肿瘤微型环境有预示的用途并且能也为对当代的癌症免疫疗法的反应预兆。对联系肿瘤的抗原的自发的 T 房间回答的产生取决于天生的有免疫力的激活,运动打它我干扰素(IFN ) 生产。最近的工作为在这个过程察觉到的 cytosolic DNA 的 STING 小径揭示了一个主要角色。事件的这串联贡献 Batf3 系树枝状的房间(DC ) 的激活,它看起来对反肿瘤免疫中央。Non-T 煽动房间的肿瘤为 Batf3 DC 招募缺乏 chemokines,有很少 Batf3 DC,并且缺乏一种类型我 IFN 基因签名,建议那没有通过天生的有免疫力的激活可以是因缺乏自发的 T 房间激活和累积的最终的原因。与手里的这个信息,为触发天生的有免疫力的激活和 Batf3 DC 招募的新策略正在被开发,包括为 de novo 免疫者 priming 的新奇圈套收缩筋。最终,有效天生的有免疫力的使活跃之物的成功的发展应该扩展能对免疫疗法作出回应的病人的部分,例如与检查点封锁抗体。 | Leticia Corrales Vyara Matson Blake Flood Stefani Spranger Thomas F Gajewski | 2017 | Cell Research2017，27，1： | 13 |
| 3 | 三相四线整流器的中线电流控制显示文摘六开关三相四线PWM整流器拓扑是适合于中大功率高频UPS装置的前级整流器拓扑。与常规的六开关三相三线整流器相比,三相四线整流器输出正负直流母线,并且输入侧存在零序电流通路,如果沿用三相三线整流器的控制方法,必然会引起很大的中线电流。针对此问题。讨论了三相四线PWM整流器输出为正负直流母线电压均衡控制和中线电流控制问题,建立了三相四线整流器数学模型,分析了中线电流产生的机理以及抑制的方法,设计了基于同步旋转坐标系的三相四线整流器的控制算法。在功率40kW的实验样机上验证了控制方法的有效性,保证了输出正负母线电压的平衡及较小的输入电流谐波。 | BORIS Luis Corral Martinez 李睿 马柯 徐德鸿 | 2009 | 电机与控制学报2009，13，3： | 7 |
| 4 | Quasispecies dynamics in main core epitopes of hepatitis B virus by ultra-deep-pyrosequencing显示文摘AIM:To investigate the variability of the main immunodominant motifs of hepatitis B virus(HBV) core gene by ultra-deep-pyrosequencing(UDPS).METHODS:Four samples(2 genotype A and 2 genotype D) from 4 treatment-na ve patients were assessed for baseline variability.Two additional samples from one patient(patient 4,genotype D) were selected for analysis:one sample corresponded to a 36-mo treatment-free period from baseline and the other to the time of viral breakthrough after 18 mo of lamivudine treatment.The HBV region analyzed covered amino acids 40 to 95 of the core gene,and included the two main epitopic regions,Th50-69 and B74-84.UDPS was carried out in the Genome Sequencer FLX system(454 Life Sciences,Roche).After computer filtering of UDPS data based on a Poisson statistical model,122 813 sequences were analyzed.The most conserved position detected by UDPS was analyzed by site-directed mutagenesis and evaluated in cell culture.RESULTS:Positions with highest variability rates were mainly located in the main core epitopes,confirming their role as immune-stimulating regions.In addition,the distribution of variability showed a relationship with HBV genotype.Patient 1(genotype A) presented the lowest variability rates and patient 2(genotype A) had 3 codons with variability higher than 1%.Patient 3 and 4(both genotype D) presented 5 and 8 codons with variability higher than 1%,respectively.The median baseline frequencies showed that genotype A samples had higher variability in epitopic positions than in the other positions analyzed,approaching significance(P = 0.07,sample 1 and P = 0.05,sample 2).In contrast,there were no significant differences in variability between the epitopic and other positions in genotype D cases.Interestingly,patient 1 presented a completely mutated motif from amino acid 64 to 67(E 64 LMT 67),which is commonly recognized by T helper cells.Additionally,the variability observed in all 4 patients was particularly associated with the E 64 LMT 67 motif.Codons 78 and 79 were highly conserved in all samples,in keeping with their involvement in the interaction between the HBV virion capsid and the surface antigens(HBsAg).Of note,codon 76 was even more conserved than codons 78 and 79,suggesting a possible role in HBsAg interactions or even in hepatitis B e antigen conformation.Sequential analysis of samples from patient 4(genotype D) illustrated the dynamism of the HBV quasispecies,with strong selection of one minor baseline variant coinciding with a decrease in core variability during the treatment-free and lamivudinetreated period.The drop in variability seemed to result from a 'steady state' situation of the HBV quasispecies after selection of the variant with greatest fitness.CONCLUSION:Host immune pressure seems to be the main cause of HBV core evolution.UDPS analysis is a useful technique for studying viral quasispecies. | Maria Homs Maria Buti David Tabernero Josep Quer Alex Sanchez Noelia Corral Rafael Esteban Francisco Rodriguez-Frias | 2012 | World Journal of Gastroenterology2012，18，42： | 5 |
| 5 | Helicobacter pylori recurrence after eradication in Latin America:Implications for gastric cancer prevention显示文摘AIM To estimate Helicobacter pylori(H. pylori) recurrence rate in Latin America, a region with a significant H. pylori prevalence and gastric cancer burden.METHODS Pub Med, LILACS, Sci ELO, Cochrane databases and abstracts from relevant meetings were reviewed. Information collected included: Participants' characteristics, recruitment strategy, diagnostic modality, treatment arms, follow-up and recurrence rates. Recurrence was calculated using 100-patients-year rates, and data were pooled using a random effects model. The I2 statistic assessed between study heterogeneity. Meta-regression analyses evaluated for effect modifying variables. RESULTS Literature search yielded 163 articles. Twelve studies involving 4848 patients from 9 countries met inclusion criteria. Four hundred and thirty-two reinfections were recorded in 5487 person-years of follow-up. Pooled analysis showed a recurrence rate of 7.9 cases per 100 person-years(95%CI: 5.3-10.5). Meta-regression revealed that neither the antibiotic schema, a second antibiotic course, nor the diagnostic modality had an impact on the observed risk of recurrence. The recurrence rate in the first year after treatment, predominantly recrudescence,was 11.2(6.1-16.4) per 100 patient years. Recurrence in subsequent years, was only 6.2(3.8-8.7).CONCLUSION H. pylori recurrence rates in Latin America are significant, and with geographic variability, yet are acceptable based upon the current literature for consideration of large scale intervention trials. Further research in Latin America is warranted to evaluate the efficacy, cost-effectiveness, and potential adverse outcomes of proposed eradication programs. | Juan E Corral Robertino Mera Corey W Dye Douglas R Morgan | 2017 | World Journal of Gastrointestinal Oncology2017，9，4： | 5 |
| 6 | 椭圆函数滤波器边带特性优化方法显示文摘本文对椭圆函数滤波器边带特性优化方法进行了研究,给出了一种新方法的详细分析、算法和设计实例。该方法充分利用滤波器阶数余量,通过相应的计算方法在不增加阶数的前提下使滤波器边带选择特性最大化,有效地减小了过渡带宽。 | 王田 Celestino A Corral 杨士中 | 2005 | 电路与系统学报2005，10，5： | 3 |
| 7 | New horizons for uncommon mutations in non-small cell lung cancer: BRAF, KRAS, RET, MET, NTRK, HER2显示文摘The 2004 discovery of EGFR mutations,followed by ALK rearrangements,ushered in a targeted therapy era for advanced non-small cell lung cancer(NSCLC).Tyrosine kinase inhibitors targeting gene alterations have substantially improved survival and quality of life for patients with NSCLC.In the last decade,rearrangements of the ROS1 oncogene have been incorporated into healthcare practice that are applicable to another small subgroup of patients who benefit from similar targeted strategies.Recent genome studies of lung adenocarcinoma have identified other possible therapeutic targets,including RET,NTRK fusions,c-MET alterations,and activating mutations in KRAS,BRAF,and HER2,all with frequencies greater than 1%.Lung cancers harbouring these genome changes can potentially be treated with agents approved for other indications or under clinical development.This review updates the therapeutic arsenal that especially targets those genes. | Maria Eugenia Olmedo Raquel Cervera Luis Cabezon-Gutierrez Yolanda Lage Elena Corral de la Fuente Ana Gomez Rueda1,Xabier Mielgo-Rubio Juan Carlos Trujillo Felipe Counago | 2022 | World Journal of Clinical Oncology2022，13，4： | 3 |
| 8 | Extraction of anthocyanins from grape by-products assisted by ultrasonics, high hydrostatic pressure or pulsed electric fields: a comparison显示文摘 | Corrales M Toepfl S Butz P | 2008 | Innovative Food Science and Emerging Technologies2008，9，1： | 1 |
| 9 | Sialic acid and cardiovascular mortality显示文摘 | Corrall RJ Waters PJ | 1991 | BMJ1991，302，： | 1 |
| 10 | Investigaciones termoquimicas sobre los acidos toluiicos ydimetilbenzoicos显示文摘 | Corral L B | 1960 | Rev R Acad Cienc1960，，54： | 1 |
| 11 | Infection control strategies in a neonatal intensive care nuit in Argentina 显示文摘 | Kurlat I Corral G Oliveira F | 1998 | J Hosp Infect1998，40，2： | 1 |
| 12 | A common polymorphism flanking the ATG initiator codon of GPIba doesnot affect expression and is not a major risk for arterial thrombosis显示文摘 | Corral J Lozano ML Gonzalez-Conejero R | 2000 | Thromb Haemost2000，83，： | 1 |
| 13 | Aerobic granulation with industrial wastewater in sequencing batch reactors 显示文摘 | Arrojo B B Mosquera Corral A Garrldo J M | 2004 | Water Res2004，38，： | 1 |
| 14 | Free radical macrophotoinitiators: an overview on recent advances显示文摘 | Corrales T Catalina F Peinado C | 2003 | Journal of Photochemistry and Photobiology A: Chemistry2003，159，2： | 1 |
| 15 | Synthesis and cytotoxicity of new aminoterpenylquinones显示文摘 | JOSE M DEL CORRAL M CASTRO M A | 2005 | Bioorganic & Medicinal Chemis- try2005，13，3： | 1 |
| 16 | Stabilityof the ANAMMOX process in a gas - lift reactor and a SBR 显示文摘 | Dapena - Mora A Campos J L Mosquera - Corral A | 2004 | journal of Biotechnology2004，110，2： | 1 |
| 17 | Extraction of anthocyanins from grape skins assisted by high hydrostatic pressure 显示文摘 | Corrales M Avelina Ferndndez Garci Peter Butz a | 2009 | J Food Eng2009，90，4： | 1 |
| 18 | Umbilical artery aneurysm:prenatal identifieation in three fetuses with trisomy 18显示文摘 | Sepulveda W Corral E Kottmann C | 2003 | Ultrasound Obstet Gynecol2003，21，3： | 1 |
| 19 | Thalidomide costimu- lates primary human T lymphocytes, preferentially inducing pro- liferation, cytokine production, and cytotoxic responses in the CD8+ subset显示文摘 | Haslett PA Corral LG Albert M | 1998 | J Exp Med1998，187，11： | 1 |
| 20 | Extraction of anthocyanins from grape by-products assisted by ultrasonics,high hydrostatic pressure or pulsed electric fields:A comparison显示文摘 | Corrales M Toepfl S Rutz P | | 0，，09： | 1 |
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