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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Optimal training sequences for channel estimation in cyclic-prefix-based single-carrier systems with transmit diversity显示文摘 | Coon J Beach M McGeehan J | 2004 | IEEE Signal Processing Letters2004，11，9： | 1 |
| 3 | Analysis of chromosome 22markers in nine schizophrenia pedigrees 显示文摘 | Coon H Holik J Hoff M | 1994 | Am J Med Genet1994，54，1： | 1 |
| 4 | Assessing the work environment for creativity 显示文摘 | AMABILE T M CONTI R COON H | 1996 | Academy of Management Journal1996，39，5： | 1 |
| 5 | The thermal stability of the polymorphs of hexanitrohexaazaisowurtzifane 显示文摘 | Foltz M F Coon C L Garcia F | 1994 | Propel- lants Explosives Pyrotechnics1994，19，： | 1 |
| 6 | A microstructure investigation of the origin of brittle behavior in the transverse direction in Mo-based alloy bars 显示文摘 | Wadsworth J Packer C M Chewey P M Coons W C | 1984 | Metallurgical Transactions A1984，15，9： | 1 |
| 7 | Diagnosis,treatment,and analysis of long-term outcomes in idiopathic normal-pressure hydrocephalus显示文摘 | McGirt M Woodworth G Coon A | 2005 | Neurosurgery2005，57，4： | 1 |
| 8 | Ammonia induces settlement behavior in oyster larvae显示文摘 | COON S L WALCH M FITT W K | 1990 | Biological Bulletin1990，179，： | 1 |
| 9 | As- sessing the Work Environment for Creativity显示文摘 | AMABILE T M CONTI R COON H | 1996 | Academy of Management Journal1996，39，5： | 1 |
| 10 | Assessing the work environment for creativity 显示文摘 | Amabile T M Conti R Coon H Lazenby J Herron M | 1996 | Academy of Management Journal1996，39，5： | 1 |
| 11 | Assessing the Work Envi- ronment for Creativity 显示文摘 | Amabile Teresa M Conti Regina Coon Heather Lazenby Jeffrey Herron Mihael | 1996 | Academy of Management Journal1996，39，5： | 1 |
| 12 | As-sessing the work environment for creativity显示文摘 | Amabile T.M Conti R Coon H Lazenby J.& Herron M | | 0，，05： | 1 |
| 13 | Assessing the work environment for creativity 显示文摘 | Amabile T M Conti R Coon H | 1996 | Academy of Man- agemet Journal1996，39，5： | 1 |
| 14 | Assessing the work environment for creativity显示文摘 | Amabile T M Conti R Coon H | 1996 | The Academy of Management Journal1996，39，5： | 1 |
| 15 | The thermal stability of the poly-morphs of HNIW( Part I ) 显示文摘 | Foltz F M Coon C L Gacia F | 1994 | Propellants Explosives and Pyrotechnics1994，19，1： | 1 |
| 16 | Effect of environmental temparature,dietary protein,and energy level on broiler performance显示文摘 | Cheng T K Hamra M L Coon C N 1997 | 1997 | Journal of Applied Poultry Research1997，6，： | 1 |
| 17 | Cytochrome P450 显示文摘 | Porter T D Coon M J | 2004 | J Biol Chem2004，266，13： | 1 |
| 18 | A Bayesian analysis of the compression set and stress-strain behavior in a thermally aged silicone foam 显示文摘 | Coons J E McKay M D Hamada M S | 2006 | Polymer Degradation and Stability2006，91，： | 1 |
| 19 | Control of oyster settlement and metamorphosis by endogenous and ex- ogenous chemical cues显示文摘 | Bonar D B Coon S L Walch M | 1990 | Bulletin of marine science1990，46，2： | 1 |
| 20 | Randomized trial ofradiation therapy plus procarbazine, lomustine, and vincri-stine chemotherapy for supratentorial adult low-gradeglioma: initial results of RTOG 9802 显示文摘 | Shaw EG Wang M Coons SW | 2012 | J Clin Oncol2012，30，： | 1 |
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