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| 1 | 面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明显示文摘尽管脑血管病有着全球性影响且对其病理生理学的认识有了很多进步,但是'卒中'这一术语在临床实践、临床研究或公共卫生评估中的定义却不一致。传统的定义依据于临床,却没有考虑到科学技术的进步。美国心脏协会(AHA)和美国卒中协会(ASA)卒中分会组织了写作小组,为21世纪卒中新定义撰写专家共识性声明。中枢神经系统(CNS)梗死,指由缺血所导致的脑、脊髓或视网膜的细胞死亡,是基于持续性损害的神经病理学、神经影像学和(或)临床证据。CNS梗死表现为一个临床谱:缺血性卒中特指伴有明显症状的CNS梗死,而静息性梗死根据定义指未引起已知的症状的梗死。卒中也还包括脑出血和蛛网膜下腔出血。新定义的卒中结合了临床和组织学标准,可被用于实践、研究和公共卫生评估。 | 俞羚 董荃 宋叶平 江静雯 李卉 刘亮贤 苏爱萍 李焰生 Sacco RL Kasner SE Broderick JP Caplan LR Connors JJ Culebras A Elkind MS George MG Hamdan AD Higashida RT Hoh BL Janis LS Kase CS Kleindorfer DO Lee JM Moseley ME Peterson ED Turan TN Valderrama AL Vinters HV | 2013 | 神经病学与神经康复学杂志2013，10，2： | 188 |
| 2 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 3 | Brain-derived neurotrophic factor and inflammation in depression:Pathogenic partners in crime?显示文摘Major depressive disorder is a debilitating disorder affecting millions of people each year.Brain-derived neurotrophic factor(BDNF)and inflammation are two prominent biologic risk factors in the pathogenesis of depression that have received considerable attention.Many clinical and animal studies have highlighted associations between low levels of BDNF or high levels of inflammatory markers and the development of behavioral symptoms of depression.However,less is known about potential interaction between BDNF and inflammation,particularly within the central nervous system.Emerging evidence suggests that there is bidirectional regulation between these factors with important implications for the development of depressive symptoms and antidepressant response.Elevated levels of inflammatory mediators have been shown to reduce expression of BDNF,and BDNF may play an important negative regulatory role on inflammation within the brain.Understanding this interaction more fully within the context of neuropsychiatric disease is important for both developing a fuller understanding of biological pathogenesis of depression and for identifying novel therapeutic opportunities.Here we review these two prominent risk factors for depression with a particular focus on pathogenic implications of their interaction. | Grace A Porter Jason C O’Connor | 2022 | World Journal of Psychiatry2022，12，1： | 4 |
| 4 | Induction of apoptosis by the Bcl-2 homologue,bak显示文摘 | Chittenden T Harrington E A O'Connor R | 1995 | Nature1995，374，6524： | 2 |
| 5 | Personalising pancreas cancer treatment:When tissue is the issue显示文摘The treatment of advanced pancreatic cancer has not moved much beyond single agent gemcitabine until recently when protocols such as FOLFIRINOX(fluorouracil,leucovorin,irinotecan and oxaliplatin)and nab-paclitaxelgemcitabine have demonstrated some improved outcomes.Advances in technology especially in massively parallel genome sequencing has progressed our understanding of the biology of pancreatic cancer especially the candidate signalling pathways that are involved in tumourogenesis and disease course.This has allowed identification of potentially actionable mutations that may be targeted by new biological agents.The heterogeneity of pancreatic cancer makes tumour tissue collection important with the aim of being able to personalise therapies for the individual as opposed to a one size fits all approach to treatment of the condition.This paper reviews the developments in this area of translational research and the ongoing clinical studies that will attempt to move this into the everyday oncology practice. | Katrin M Sjoquist Venessa T Chin Lorraine A Chantrill Chelsie O'Connor Chris Hemmings David K Chang Angela Chou Marina Pajic Amber L Johns Adnan M Nagrial Andrew V Biankin Desmond Yip | 2014 | World Journal of Gastroenterology2014，20，24： | 2 |
| 6 | lntrathecal HIV- 1 envelope glycoprotein gp120 induces enhanced pain states mediated by spinal cord proinflammatory cytokines 显示文摘 | Milligan E D O'Connor K A Nguyen K T | 2001 | J Neurosci2001，21，8： | 1 |
| 7 | Phase solubility techniques 显示文摘 | HIGUCHI T CONNORS K A | 1965 | Advances in Analytical Chemistry and Instrumentation1965，4，： | 1 |
| 8 | 9-bromonoscapine induced mitotic arrest of cigarette smoke condensate-trans formed breast epithelial cells 显示文摘 | Jaiswal A S Aneja R Connors S K | 2009 | J Cell Biochem2009，106，6： | 1 |
| 9 | Heavy metal sequential extraction methods-A modification for tropical soils显示文摘 | SILVEIRA M L ALLEONI L R F O' CONNOR G A | 2006 | Chemosphere2006，64，： | 1 |
| 10 | The stability of cyclodextrin complexes in solution 显示文摘 | Connors K A | 1997 | Chemical Reviews1997，97，5： | 1 |
| 11 | Effects of residual and reapplied biosolids on performance and mineral status of grazing beef steers显示文摘 | Tiffany M E Me Dowell L R O'connor G A etal | 2002 | Journal of Animal Science2002，80，： | 1 |
| 12 | Changes in fruit antioxidant activity among blueberry cultivars during cold-temperature storage显示文摘 | Connor A M | 2002 | Journal of Agricultural and Food Chemistry2002，50，4： | 1 |
| 13 | The cytosolic subunit p67^phax contains an NADPH-binding site that participates in catalysis by the leukocyte NADPH oxidase 显示文摘 | SMITH R M CONNOR J A CHEN L M | 1996 | J Clin Invest1996，，98： | 1 |
| 14 | Genotypic and environmental variation in antioxidant activity, total phenolic content, and anthocyanin content among blueberry cultivars显示文摘 | CONNOR A M LUBY J J TONG C B S | 2002 | Journal of American Society for Horticultural Science2002，127，1： | 1 |
| 15 | The Stability of Cyclodextrin Complexes in Solution显示文摘 | Connors K A | 1997 | Chem Rev1997，，97： | 1 |
| 16 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 17 | Pharmacologic management of neuropathic pain: evidence - based recommendations 显示文摘 | DWORKIN R H O'CONNOR A B BACKONJA M | 2007 | Pain2007，132，3： | 1 |
| 18 | Local music policies within a global music industry:cultural quarters in Manchester and Sheffield 显示文摘 | Brown A O'Connor J Coben S | 2000 | Geoforum2000，31，4： | 1 |
| 19 | The atretic plate--a conduit for dril vibration to the inner ear?显示文摘 | Eze N Jiang D O'Connor A F | 2014 | Acta Oto-Laryngologica2014，134，1： | 1 |
| 20 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
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