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| 1 | Outlining key inflammation-associated parameters during early phase of an experimental gram-negative sepsis model in rhesus macaques(Macaca mulatta)显示文摘The aim of this study was to identify inflammation-associated markers during the early phase of sepsis in rhesus macaque. Four rhesus macaques were given an intravenous dose of 1010 CFU/kg of E. coli. Blood samples were collected before, or 30 minutes, 2, 4, 6 and 8 hours after E. coli infusion. Physiological parameters, bacteremia, endotoxemia, C-reactive protein(CRP), procalcitonin(PCT), and plasma cytokines/chemokines were determined for each animal. Bacteremia was present in all animals from 30 minutes to 3 hours after E. coli infusion whereas endotoxin was detected during the full-time course. CRP and PCT levels remained at detectable levels during the whole experimental window suggesting an ongoing inflammatory process. Signature cytokines and chemokines such as TNF-α, MIP-1α, and MIP-1β peaked about 2 hours after E. coli infusion and decreased thereafter. Plasma IL-6, IL-12 p40, IFN-γ, and IL-1 Ra, as well as I-TAC, MIG, IP-10 and MCP-1, remained at detectable levels after 4 hours of E. coli infusion. This nonhuman primate model could be useful for the assessment of new therapeutics aiming to suppress key inflammatory markers throughout sepsis early phases. | Jose J.Rosado-Franco Marcos J.Ramos-Benitez Laura M.Parodi Derick Rosario Nicole Compo Luis D.Giavedoni Ana M.Espino | 2019 | Animal Models and Experimental Medicine2019，2，4： | 5 |
| 2 | A practical guide to wavelet analysis 显示文摘 | TORRENCE C COMPO G P | 1988 | Bulletin of the American Meteorological Society1988，79，1： | 1 |
| 3 | A practical guide to wavelet analysis显示文摘 | Torrence C Compo G P | 1998 | Bulletin of the American Meteorological Society1998，79，： | 1 |
| 4 | A practical guide to wavelet analysis显示文摘 | Torrence C Compo G P | 1998 | Bull Amer Meteor Soc1998，79，1： | 1 |
| 5 | A practical guide to wavelet analysis显示文摘 | TORRENCE C COMPO G P | 1998 | Bull Am Meteor Soc1998，79，1： | 1 |
| 6 | A practical guide to wavelet analysis 显示文摘 | Torrence C Compo G P | 1998 | Bulletin of the American Meteorological Society1998，79，1： | 1 |
| 7 | A practical guide to wavelet analysis显示文摘 | Torrence C Compo G P | 1995 | Bulletin of the American Meteorological Society1995，79，： | 1 |
| 8 | A practical guide to wavelet analysis显示文摘 | TORRENCE C COMPO G P | 1998 | Bulletin of the American Meteorological Society1998，79，1： | 1 |
| 9 | A Practical Guide to Wavelet Analysis 显示文摘 | Torrence C Compo G P | 1998 | Bulletin of the American Meteorological Society1998，79，1： | 1 |
| 10 | A practical guide to wavelet analysis 显示文摘 | Torrence C Compo G P | 1998 | Bull Amer Meteor Soc1998，79，1： | 1 |
| 11 | A Practical Guide to Wavelet Analysis 显示文摘 | Torrence C Compo G P | 1997 | Bulletin of the American Metorological Society1997，79，1： | 1 |
| 12 | A practical guide to wavelet analy- sis 显示文摘 | TORRENCE C COMPO G | 1998 | Bulletin of the American Meteorological Society1998，79，1： | 1 |
| 13 | A Practical Guide to Wavelet Analysis显示文摘 | TORRENCE C COMPO G P | 1998 | Bulletin of The American Meteorological Society1998，79，1： | 1 |
| 14 | A practical guide to wavelet analysis显示文摘 | Torrence C Compo G P | 1998 | Bulletin of American Meteorological Soci- ety1998，79，： | 1 |
| 15 | A practical guide to wavelet analysis显示文摘 | Torrence C and Compo G P | 1998 | Bulletin of the American Meteorological Socitety1998，79，1： | 1 |
| 16 | Distribution of the 72-kd type Ⅳ collagenase in nonneoplastic thyroid tissue显示文摘 | Compo E Merion MJ LiottaL etal | 1992 | Hum Pathol1992，23，12： | 1 |
| 17 | A practical guide to wavelet analysis 显示文摘 | Torrence C Compo G P | 1998 | Bulletin of the American Meteorological Society1998，79，1： | 1 |
| 18 | A Practical Guide to Wavelet Analysis 显示文摘 | Torrence C Compo G P | 1998 | Bulletin of American Meteorological Society1998，79，： | 1 |
| 19 | A practical guide to wavelet analysis显示文摘 | Torrence C Compo G P | 1998 | Bull Amer Meteor Soc1998，79，： | 1 |
| 20 | A practical guide to wavelet analysis显示文摘 | Compo G P | 1998 | Bull Am Meteor Soc1998，79，1： | 1 |
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