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| 1 | Colorectal cancer and immunity:what we know and perspectives显示文摘Strong evidence supports the concept of immunosurveillance and immunoediting in colorectal cancer.In particular,the density of T CD8+and CD45+lymphocyte infiltration was recently shown to have a better prognostic value than the classic tumor node metastasis classification factor.Other immune subsets,as macrophages,natural killer cells or unconventionnal lymphocytes,seem to play an important role.Induction of regulatory T cells(Tregs)or immunosuppressive molecules such as PD-1 or CTLA-4 and downregulation of antigen-presenting molecules are major escape mechanisms to antitumor immune response.The development of these mechanisms is a major obstacle to the establishment of an effective immune response,but also to the use of immunotherapy.Although im-munotherapy is not yet routinely used in colorectal cancer,we now know that most treatments used(chemotherapy and biotherapy)have immunomodulatory effects,such as induction of immunogenic cell death by chemotherapy,inhibition of immunosuppression by antiangiogenic agents,and antibody-dependent cytotoxicity induced by cetuximab.Finally,many immunotherapy strategies are being developed and tested in phaseⅠtoⅢclinical trials.The most promising strategies are boosting the immune system with cytokines,inhibition of immunoregulatory checkpoints,vaccination with vectorized antigens,and adoptive cell therapy.Comprehension of antitumor immune response and combination of the different approaches of immunotherapy may allow the use of effective immunotherapy for treatment of colorectal cancer in the near future. | Simon Pernot Magali Terme Thibault Voron Orianne Colussi Elie Marcheteau Eric Tartour Julien Taieb | 2014 | World Journal of Gastroenterology2014，20，14： | 19 |
| 2 | Early renal failure as a cardiovascular disease:Focus on lipoprotein(a) and prothrombotic state显示文摘Patients with renal failure are at increased risk of cardiovascular events even at the earliest stages of disease.In addition to many classic cardiovascular risk factors,many conditions that are commonly identified as emerging risk factors might contribute to occurrence of cardiovascular disease.Changes in circulating levels of many of these emerging risk factors have been demonstrated in patients with early stages of renal failure caused by different types of renal disease and have been associated with detection of cardiovascular complications.However,for most of these factors evidence of benefits of correction on cardiovascular outcome is missing.In this article,we comment on the role of lipoprotein(a) and prothrombotic factors as potential contributors to cardiovascular events in patients with early renal failure. | Cristiana Catena Gian Luca Colussi Francesca Nait Francesca Pezzutto Flavia Martinis Leonardo A Sechi | 2015 | World Journal of Nephrology2015，4，3： | 4 |
| 3 | Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study显示文摘BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected patients.However,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well established.AIM To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with DAAs.METHODS Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern Italy.The study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be confounders.RESULTS The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persists in patients with advanced liver disease or with complications,such as mixed cryoglobulinemia or renal failure. | Gian Luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo | 2019 | World Journal of Gastroenterology2019，25，40： | 4 |
| 4 | 高血压患者同型半胱氨酸水平升高与代谢综合征和心血管事件相关显示文摘高同型半胱氨酸(homocysteine,Hcy)血症和代谢综合征(metabolic syndrome,MS)是明确的心血管危险因素,常与高血压相关。然而血浆Hcy与MS、胰岛素抵抗相关性存在争议,且在高血压患者中的研究较少。该研究探讨高血压患者Hcy与MS和心脑血管事件的相关性。 | Catena C Colussi G Nait F Capobianco F Sechi LA 陈云 叶鹏 | 2016 | 中华高血压杂志2016，24，1： | 2 |
| 5 | Pd/CeO2甲烷氧化催化剂的构效关系显示文摘钯基催化剂是甲烷氧化活最具活性的催化剂.在宏观和纳米尺度上,它们的组成、结构和形态的调整可以显著改变其催化行为和稳定性,对催化剂的整体性能有很大的影响.在已经应用的几种载体和促进剂组合中, Pd/CeO2由于其活性和耐用性以及Pd/Pd O载体之间较强的相互作用而引起了人们的极大关注.这使得人们可在纳米尺度上创建特定的结构,从而对甲烷活化特性产生重大的影响.本文综述了该领域的最新发现,特别是设想如何在纳米尺度上尽可能控制Pd-CeO2相互作用,从而有助于设计更强劲的甲烷氧化催化剂. | Sara Colussi Paolo Fornasiero Alessandro Trovarelli | 2020 | Chinese Journal of Catalysis2020，41，6： | 2 |
| 6 | The role of rare earth oxides as promoters and stabilizers in combustion catalysts 显示文摘 | Colussi S de Leitenburg C Dolcetti G | 2004 | Alloys Compd2004，374，： | 1 |
| 7 | Photodynamic therapy: A new concept in medical treatment 显示文摘 | Sibata CH Colussi VC Oleinick NL | 2000 | Braz J Med Biol Res2000，33，8： | 1 |
| 8 | Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients 显示文摘 | Colussi G Catena C Lapenna R | 2007 | Diabetes Care2007，30，9： | 1 |
| 9 | An efficient and reusable catalyst based on Pd/CeOz for the room temperature aerobic Suzuki-Miyaura reaction in water/ethanol显示文摘 | AMOROSO F COLUSSI ZOTTO A DE | 2010 | Journal of Molecular Catalysis A: Chemical2010，315，19： | 1 |
| 10 | Photodynamic therapy in oncology显示文摘 | Sibata CH Colussi VC Oleinick NL | 2001 | Expert Opin phamacother2001，2，： | 1 |
| 11 | The role of rare earth oxides as promoters and stabilizers in combustion catalysts显示文摘 | Sara Colussi Carlade Leitenburg Giuliano Dolcetti | 2004 | Journal of Alloys and Compounds2004，374，： | 1 |
| 12 | Relationships ofplasma renin levels with renal function in patients withprimary aldosteronism 显示文摘 | Catena C Colussi G Nadalini E | 2007 | Clin Am Soc Nephrol2007，，2： | 1 |
| 13 | Fish meal supplementation and ambulatory blood pressure in patients with hypertension:relevance of baseline membrane fatty acid composition显示文摘 | Colussi G Catena C Dialti V | 2014 | Am J Hypertens2014，27，3： | 1 |
| 14 | Photodynamic therapy: A new concept in medical treatment 显示文摘 | Sibata CH Colussi VC Oleinick NL | 2000 | Braz J Med Biol Res2000，33，： | 1 |
| 15 | Photodynamic therapy in oncology显示文摘 | Sibata CH Colussi VC Kinsella TJ | 2010 | Expert Opin Pharmacother2010，2，6： | 1 |
| 16 | Oxidative power of nitrogen - doped TiO2 photocatalysts undervisible illumination 显示文摘 | Marta M Willim B Colussi A J | 2004 | Journal of Physical Chemistry B2004，108，17： | 1 |
| 17 | Long-term cardiac effects of adrenalectomy or mineralocorticoid antagonists in pa- tients with primary aldosteronism显示文摘 | Catena C Colussi GL Lapenna R | 2007 | Hypertension2007，50，5： | 1 |
| 18 | Cardiovascular outcomes in patients with primary aldosteronism after treatment显示文摘 | Catena C Colussi G Nadalini E | 2008 | Arch Intern Med2008，168，1： | 1 |
| 19 | The effect of CeO, on the dynamics of Pd-Pdo transformation over Pd/Al2O3 combustion catalysts 显示文摘 | Colussi S TrovareUi A Groppi G | 2007 | Catal Commun2007，8，8： | 1 |
| 20 | Rice Germination and Its Impact on Technological and Nutritional Properties:A Review显示文摘Grain germination is a process involving numerous factors that influence the biochemical processes inside the plant cells.This review covered the abiotic factors that lead to the germination and significantly impact the nutritional properties and digestion behavior of rice grains.The macro-and micro-nutrients can be changed depending on the intensity of the applied variables during germination.For instance,germination time can increase the protein content in the grain and concurrently reduce its protein digestibility.In most cases,the number of bioactive compounds present in rice grains are increased regardless of germination conditions.Germination can promote the complexation of nutrients and thus negatively interfere with the digestibility of macronutrients.This review highlighted the influence of the germination process on the nutritional quality of rice grains,providing information about the germination conditions and their impacts on the anabolic and catabolic reactions of the grain,emphasizing the health benefits. | LucasÁvila do NASCIMENTO Abhilasha ABHILASHA Jaspreet SINGH Moacir Cardoso ELIAS Rosana COLUSSI | 2022 | Rice science2022，29，3： | 1 |
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