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| 1 | 尿激酶治疗急性心肌梗塞多中心临床试验1406例总结显示文摘为观察尿激酶天普洛欣(UKTP)经静脉溶栓治疗急性心肌梗塞(AMI)的临床有效性及安全性。收集协作组148家医院1994年11月至1996年4月经静脉UKTP溶栓治疗AMI患者1406例,观察临床疗效、副作用及病死率等。其中124例行90分钟冠状动脉造影评价梗塞血管开通情况。结果:梗塞血管临床再灌注率为73.5%,90分钟冠状动脉造影血管开通率为72.6%,5周总病死率为7.8%(109/1406),轻度出血10.2%(143/1406),中重度出血0.43%(6/1406),脑出血0.50%(7/1406)。老年(>65岁)甚至高龄(>75岁)患者溶栓及距发病超过6小时者,其用药仍然安全有效,UKTP合适的用药剂量可能为150万U左右。结果提示UKTP治疗AMI安全有效。 | The collaborative study group for national multicenter clinical trial of urokinase thrombolytic therapy (Correspondence: Hu Dayi, Xu Zhimin. Beijing Red Cross Chao Yao Hospital, Beijing 100020) | 1997 | 中华心血管病杂志1997，25，3： | 139 |
| 2 | 不稳定性心绞痛、急性非Q波心肌梗死不同抗栓疗法的对比研究显示文摘目的 观察不同抗栓方案对急性冠状动脉综合征心脏事件、出血风险和预后的影响。方法 本研究为前瞻性、多中心、随机、开放试验 ,入选患者随机分为静脉滴注普通肝素组和皮下注射低分子量肝素组。入选对象为不稳定性心绞痛或非Q波心肌梗死 ,入选前 4 8小时以内至少有一次心绞痛发作 ,ST段无抬高。肝素 10 0IU/kg静注 ,续 10 0 0IU/h ,维持活化的部分凝血活酶时间 (APTT)或活化的全血凝固时间 (ACT)于正常的 1 5~ 2 0倍 ,连续 7日。低分子量肝素 0 4~ 0 6ml,每日两次皮下注射 ,连续 7日。主要观察终点 :随访治疗 3 0日内发生急性心肌梗死、心脏性或非心脏性死亡和药物治疗无法控制心绞痛 ,需行急性血运重建术。住院至少 7日 ,随访至治疗后 3 0日。结果 本研究共入选符合条件的患者 4 0 2例 ,两组在性别、年龄、心血管危险因素和心绞痛发作方面差异无显著性。治疗后 7日 ,两组用药期间平均胸痛发作次数差异无显著性 ,但肝素组有更多的患者需口服硝酸甘油缓解胸痛 ;病死率在低分子量肝素组较普通肝素组低 ,两组比较P值为 0 0 62 ,复合终点事件 (死亡、心肌梗死和紧急血管重建 )在低分子量肝素组明显下降。低分子量肝素组出血事件明显少于肝素组。治疗开始后 3 0日 ,低分子量肝素组死亡和复合终点事? | Clinical Collaborative Study Group of Low Molecular Weight Heparin (Correspondent: HU Dayi, XU Juntang. Beijing Red Cross Chaoyang Hospital, Beijing University of Medical Sciences, Beijing 100020, China) | 2000 | 中华心血管病杂志2000，28，1： | 172 |
| 3 | 女性急性心肌梗塞的临床特点显示文摘目的为了解女性急性心肌梗塞(AMI)的临床特点,以提高防治效果。方法对北京地区防治冠心病协作组1990~1991年连续收治的1614例患者(男1185,女429),进行男女比较分析。根据患者年龄分为(<45,45~54,55~64,≥65岁)四组,比较患者例数、并发症及病死率。结果四组男与女患者比例分别为17.8:1,6.1:1,3.2:1和1.8:1。女性并发心源性休克者明显多于男性。发病4周病死率,女性14.7%明显高于男性9.4%。在45~54岁组内,差异亦有显著性(1.2%比0.7%)。结论提示与年龄有关的雌激素水平变化对女性AMI临床特点有明显的影响。 | Beijing Collaborative Study Group of Coronary Heart Disease 100700 (correspondewce: Beijing General Hospital, PLA, Beijing 100700) | 1998 | 中华心血管病杂志1998，26，3： | 47 |
| 4 | Oral captopril versus placebo among 14962 patients with suspected acute myocardial infarction: a multicenter,randomized,double-blind,placebo controlled clinical trial显示文摘Oralcaptoprilversusplaceboamong14962patientswithsuspectedacutemyocardialinfarction:amulticenter,randomized,double┐blind,place... | Chinese Cardiac Study (CCS 1) Collaborative Group | 1997 | Chinese Medical Journal1997，，11： | 5 |
| 5 | MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals:a randomised placebo-controlled trial显示文摘 | Heart Protection Study Collaborative Group | | The Lancet0，，： | 2 |
| 6 | Randomised trial of intravenous Streptokinase,oral aspirin,both,or,neithcr among 17,187 cases of suspected acute myocardial infarction: ISIS-2 显示文摘 | Collins R Yusuf S ISIS-2 ( Second International Study of Infarct Survival Collaborative Group ) | | Lancet0，，： | 2 |
| 7 | C-reactive protein concentration and the vascular benefits of statin therapy: an analysis of 20 536 patients in the Heart Protection Study显示文摘 | Heart Protection Study Collaborative Group | 2011 | The Lancet . 2011 (9764)2011，，： | 2 |
| 8 | Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17187 cases of suspected acute myocardial infarction显示文摘 | ISIS-2( Second Intemational Study of Infarct Survival)Collaborative Group | 1988 | lancet1988，345，8613： | 1 |
| 9 | Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on morality and major morbidity in myo- cardial infarction survivors : a randomized trial 显示文摘 | Study of the Effectiveness of Additional Reductions in Cholesteroland Homocysteine (SEARCH) Collaborative Group Armitage JM Bowman L | 2010 | JAMA2010，303，24： | 1 |
| 10 | Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction:a double-blind randomised trial显示文摘 | Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group | | The Lancet0，，： | 1 |
| 11 | Randomized trial of intravenous streptokinase , oral aspirin ,both or neither among 17187 cases of suspected acute my ocardial in faretion显示文摘 | ISIS -2 ( stcond international study of in farctionsurviral ) Collaborative Group | 1988 | Lancet1988，2，： | 1 |
| 12 | MRC/BHF Heart protection study of cholesterol lowering with simvastatin in 20536 high-risk individuals:a randomized placebo-controlled trial显示文摘 | Heart protection study collaborative Group | 2002 | Lancet2002，360，： | 1 |
| 13 | Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults显示文摘 | O'Leary DH Polak JF Kronmal RA Manolio TA Burke GL Wolfson SK and The Cardiovascular Health Study Collaborative Research Group | 1999 | N Engl J Med1999，340，246： | 1 |
| 14 | MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536high-risk individuals:a randomised placebo-controlled trial显示文摘 | Heart Protection Study Collaborative Group | 2002 | Lancet2002，360，9326： | 1 |
| 15 | Minimally invasive liver resection for huge(≥10cm)tumors:an international multicenter matched cohort study with regression discontinuity analyses显示文摘Background:The application and feasibility of minimally invasive liver resection(MILR)for huge liver tumours(≥10 cm)has not been well documented.Methods:Retrospective analysis of data on 6,617 patients who had MILR for liver tumours were gathered from 21 international centers between 2009-2019.Huge tumors and large tumors were defined as tumors with a size≥10.0 cm and 3.0-9.9 cm based on histology,respectively.1:1 coarsened exact-matching(CEM)and 1:2 Mahalanobis distance-matching(MDM)was performed according to clinically-selected variables.Regression discontinuity analyses were performed as an additional line of sensitivity analysis to estimate local treatment effects at the 10-cm tumor size cutoff.Results:Of 2,890 patients with tumours≥3 cm,there were 205 huge tumors.After 1:1 CEM,174 huge tumors were matched to 174 large tumors;and after 1:2 MDM,190 huge tumours were matched to 380 large tumours.There was significantly and consistently increased intraoperative blood loss,frequency in the application of Pringle maneuver,major morbidity and postoperative stay in the huge tumour group compared to the large tumour group after both 1:1 CEM and 1:2 MDM.These findings were reinforced in RD analyses.Intraoperative blood transfusion rate and open conversion rate were significantly higher in the huge tumor group after only 1:2 MDM but not 1:1 CEM.Conclusions:MILR for huge tumours can be safely performed in expert centers It is an operation with substantial complexity and high technical requirement,with worse perioperative outcomes compared to MILR for large tumors,therefore judicious patient selection is pivotal. | Tan-To Cheung Xiaoying Wang Mikhail Efanov Rong Liu David Fuks Gi-Hong Choi Nicholas LSyn Charing CChong Iswanto Sucandy Adrian KHChiow Marco VMarino Mikel Gastaca Jae Hoon Lee TPeter Kingham Mathieu D’Hondt Sung Hoon Choi Robert PSutcliffe Ho-Seong Han Chung Ngai Tang Johann Pratschke Roberto ITroisi Brian KPGoh International Robotic and Laparoscopic Liver Resection Study Group Collaborators | 2021 | Hepatobiliary Surgery and Nutrition2021，10，5： | 1 |
| 16 | Treatment of severe meconium aspiration syndrome with porcine surfactant: a muhicenter, randomized, controlled trial显示文摘 | Chinese Collaborative Study Group for Neonatal Respiratory Diseases | 2005 | Acta Paediatr2005，94，6： | 1 |
| 17 | Effects of cholesterol-lowering with simvastatin on stroke and other major vascular events in 20 536 people with cerebrovascular disease or other high-risk conditions显示文摘 | Heart Protection Study Collaborative Group | 2004 | Lancet2004，363，9411： | 1 |
| 18 | Prognosis of epilepsy in newly referred patients :a prospective study of the effects of monotherapy on the long-term course of epilepsy显示文摘 | Collaborative Group for the study of epilepsy | 1992 | Epilepsia1992，33，： | 1 |
| 19 | Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12, 064 survivors of myocardial infarction: a double-blind randomised trial 显示文摘 | Study of the Effectiveness of Cholesterol and Homocysteine Additional Reductions in ( SEARCH ) Collaborative Group | 2010 | Lancet2010，376，9753： | 1 |
| 20 | Oral captopril versusplacebo among 13 634 patients with suspected acute myocardial infarction:interim report from the Chinese Cardiac Study (CCS-1)显示文摘 | Chinese Cardiac Study Collaborative Group | 1995 | Lancet1995，345，： | 1 |
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