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| 1 | Platelet-rich plasma for muscle injuries: A systematic review of the basic science literature显示文摘BACKGROUND Platelet-rich plasma(PRP) is an increasingly used biologic adjunct for muscle injuries, as it is thought to expedite healing. Despite its widespread use, little is known regarding the mechanisms by which PRP produces its efficacious effects in some patients.AIM To clarify the effects of PRP on muscular pathologies at the cellular and tissue levels by evaluating the basic science literature.METHODS A systematic review of PubMed/MEDLINE and EMBASE databases was performed using the Preferred Reporting Items for Systematic Reviews and MetaAnalyses(PRISMA) guidelines and checklist. Level III in vivo and in vitro studies examining PRP effects on muscles, myocytes and/or myoblasts were eligible for inclusion. Extracted data included PRP preparation methods and study results.RESULTS Twenty-three studies were included(15 in vivo, 6 in vitro, 2 in vitro/in vivo). Only one reported a complete PRP cytology(platelets, and red and white blood cell counts). Five in vitro studies reported increased cellular proliferation, four reported increased gene expression, and three reported increased cellular differentiation. Five in vivo studies reported increased gene expression, three reported superior muscle regeneration, and seven reported improved histological quality of muscular tissue.CONCLUSION The basic science literature on the use of PRP in muscle pathology demonstrates that PRP treatment confers several potentially beneficial effects on healing in comparison to controls. Future research is needed to determine optimal cytology,dosing, timing, and delivery methods of PRP for muscle pathologies. | Kyle N Kunze Charles P Hannon Jared D Fialkoff Rachel M Frank Brian J Cole | 2019 | World Journal of Orthopedics2019，10，7： | 6 |
| 2 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence显示文摘 | Cole ST Brosch R Parkhill J | | 0，，： | 2 |
| 3 | Observations of the RT instability in laser imploded microballoons显示文摘 | Wark J S Kilkeany J D Cole A J | 1986 | Appl Phys Lett1986，48，15： | 2 |
| 4 | Response of dairy cows to high doses of a sustained- release bovine somatotropin administered during two lactations显示文摘 | EPARD P J HUDSON S COLE W J | 1991 | J Dairy Sci1991，74，： | 2 |
| 5 | Management of venous thromboembolism in patients with advanced cancer: a systematic review and meta-analysis显示文摘 | Simon IR Noble Mike D Shelley Bernadette Coles Susan M Williams Andrew Wilcock Miriam J Johnson | 2008 | Lancet Oncology2008，，6： | 2 |
| 6 | A Refinement of the Crystal Structure of Gypsum CaSO4 · 2H2O 显示文摘 | Cole W F Lancucki C J | 1974 | Acta Crystallogphy1974，30，： | 1 |
| 7 | Rehtionship between cellulolytic activity and adhesion to cellulose in Ruminococcus Atbus 显示文摘 | Morris E J Cole O J | 1987 | J Gen Microbiol1987，133，： | 1 |
| 8 | Deciphering the biology of Mycobacteriurn tuberculosis from the complete genome sequence 显示文摘 | Cole S T Broseh R Parkhill J | 1998 | Nature1998，393，： | 1 |
| 9 | Molecular genetics and pathogenesis of Clostridium perfringens 显示文摘 | COLE S T | 1991 | Microbiol Rev1991，55，： | 1 |
| 10 | EEG alpha activity reflects attentional demands,and beta activity reflects emotional and cognitive processes显示文摘 | RAY W J COLE H W | 1985 | Science1985，228，4700： | 1 |
| 11 | Terminal restriction fragment length polymorphism an analysis program,a web-based research tool for microbial community analysis显示文摘 | Marsh T L Saxman P Cole J | 2000 | Appl Environ Microbiol2000，66，8： | 1 |
| 12 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence显示文摘 | Cole S T Brosch R Parkhill J | 1998 | Nature1998，393，6685： | 1 |
| 13 | Novel bronsted acidic ionic liquids and their use as dual solvent-catalysts显示文摘 | Cole A C Jensen J L Ntai I | 2002 | Journal of the American Chemical Society2002，124，21： | 1 |
| 14 | Damper models for heav5 vehicle-ride dynamics显示文摘 | Besinger F H Cebon D Cole D J | 1995 | Vehicle System Dynamics1995，24，1： | 1 |
| 15 | The dietary energy values of soya-bean oil, tallow and their blends for growing/finishing pigs显示文摘 | WISEMAN J COLE D J A HARDY B | 1990 | Animal Production1990，50，3： | 1 |
| 16 | The Forgotten Stakeholder? Ethics and Social Respon- sibility in Relation to Competitors 显示文摘 | Spence L J Coles A Harris L | 2001 | Business and Society Review2001，106，4： | 1 |
| 17 | Temperature-humidity indices as indicators of milk p roduction losses due to heat stres s显示文摘 | Bohmanova J Misztal I Cole J B | 2007 | J Dairy Sci2007，90，： | 1 |
| 18 | Risk factors and outcomes in patients with coronary artery aneurysms显示文摘 | BAMAN T S COLE J H DEVIREDDY C M | 2004 | Am J Cardiol2004，93，12： | 1 |
| 19 | Bacterial production in fresh and saltwater ecosystems : a cross - system overview显示文摘 | Cole J J Findlay S Pace M L | 1988 | Mar Ecol Prog Set1988，43，： | 1 |
| 20 | Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence显示文摘 | Cole ST Broseh R Parkhill J | 1998 | Nature1998，393，6685： | 1 |
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