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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Paired box gene 8-peroxisome proliferator-activated receptor-gamma fusion protein and loss of phosphatase and tensin homolog synergistically cause thyroid hyperplasia in transgenic mice显示文摘 | Diallo-Krou E Yu J Colby LA | 2009 | Endocrinology2009，150，11： | 1 |
| 3 | Rhodium - Catalyzed C--C Bond Formation via heteroatom - directed C--H bond activation 显示文摘 | COLBY D A BERGMAN R G ELLMAN J A | 2010 | Chem Rev2010，110，2： | 1 |
| 4 | Lung nodule enhancement at CT:prospective findings 显示文摘 | Swensen S J Brown L R Colby T V | 1996 | Radiology1996，201，2： | 1 |
| 5 | Synthesis and characterization of long chain branched isotactic polypropylene via metallocene catalyst and T-reagent 显示文摘 | Langston J A Colby R H Chung T C M | 2007 | Macromolecules2007，40，8： | 1 |
| 6 | A critical examination of the immunophenotype of pulmonary sclerosing hemangioma显示文摘 | Colby TV Rouse RV | 2000 | Am J Surg Pathol2000，24，3： | 1 |
| 7 | 4He D-state effects in the 2H(d, ),)4 He reaction at low energies显示文摘 | WELLER H R COLBY P LANGENBRUN- NER J L | 1986 | Physical Re- view C1986，34，1： | 1 |
| 8 | Pulmonary nodules:CT evaluation of enhancement with iodinated contrast material显示文摘 | Swensen S J Brown L R Colby T V | 1995 | Radiology1995，，： | 1 |
| 9 | Lung nodule enhancement at CT: Prospective finding 显示文摘 | SWENSEN S J BROWN LR COLBY TV | 1996 | Radiology1996，201，： | 1 |
| 10 | Toward a Conuergence of Cognitiue and Symbolic Anthropology显示文摘 | FERNANDEZ J W KRONENFELD D B | 1981 | American Ethnologist1981，8，3： | 1 |
| 11 | Synthesis and Characterization of Long Chain Branched Isotactic Poly- propylene via Metalloeene Catalyst and T-Reagent显示文摘 | Langston J A Colby R H Chung T C M | 2007 | Macro- molecules2007，40，8： | 1 |
| 12 | Overexpression of cyclooxygenase-2 (COX-2) in the mouse urinary bladder induces the expression of immuneand cell proliferation-related genes 显示文摘 | Wang X Colby J K Rengel R C | 2009 | Mol Carcinog2009，48，1： | 1 |
| 13 | Synthesis of Dihydropyridines and Pyridines from Imines and Alkynes via C-H Activation显示文摘 | Colby D A Bergman R G Ellman J A | 2008 | J Am Chem Soc2008，130，11： | 1 |
| 14 | Polymethoxylated flavones induce Ca^2+-mediated apoptosis in breast cancer cells 显示文摘 | SERGEEV I N LI S COLBY J | 2006 | Life Sci2006，80，3： | 1 |
| 15 | Thoracic lymphangiomas,lymphangiectasis,lymphangiomatosis,and lymphatic dysplasia syndrome显示文摘 | Faul J L Berry G J Colby T V | 2000 | Am J Respir Crit Care Med2000，161，31： | 1 |
| 16 | Lymphangioleiomyomatosis:clinical course in 32 patients显示文摘 | Taylor JR Ryu J Colby TV | 1990 | N Engl J Med1990，323，18： | 1 |
| 17 | Remote sensing and geomorphometry for studying relief production in high mountains 显示文摘 | BISHOP M P SHRODER JR J F COLBY J D | 2003 | Geomorphology2003，55，： | 1 |
| 18 | Developmental anatomy of direct shoot organogenesis from leaf petioles of Vitis vinifera (Vitaceae)显示文摘 | Colby S M Juncosa A M Stamp J A | 1991 | Am J Bot1991，78，2： | 1 |
| 19 | Cytosolic factors which affect microsomal lipid peroxidation in lung and liver显示文摘 | Wright J R Colby H D | 1981 | Arch Biochem Biophys1981，206，： | 1 |
| 20 | Dynamics in Miscible Blends of Polystyrene and Poly(vinyl methyl ether) 显示文摘 | Pathak J A Colby R H Floudas G | 1999 | Macromolecules1999，32，： | 1 |
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