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| 1 | Triglyceride levels and apolipoprotein E polymorphism in patients with acute pancreatitis显示文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients' progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption. | Radka Ivanova Susana Puerta Alfonso Garrido Ignacio Cueto Ana Ferro María José Ariza Andrés Cobos Pedro González-Santos Pedro Valdivielso | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 26 |
| 2 | Determination of REE,U,Тh,Ba,and Zr in simulated hydrogeological leachates by ICP-AES after matrix solvent extraction显示文摘A fast, reliable and precise method for the determination of Ba, Zr, Th, U, La, Ce, Eu, Hf and Gd in leaching solutions containing up to 1 mol/L FeCl3 by inductively coupled plasma-atomic emission spectrometry(ICP-AES) was described.Liquid-liquid extraction with diethyl ether was applied for selective and quantitative extraction of the iron with a decontamination factor of 65000.The study has enabled the determination of rare earth elements, U, Th Ba, and Zr, from the solution with high iron content with detection limits in the range of 1-24 ng/ml and a precision of 0.9%-4.6 % relative standard deviation.The developed method was simple and was adopted for implementation in a glove box for handling radioactive materials. | Marin Ayranov Joaquin Cobos Karin Popa Vincenzo V.Rondinella | 2009 | Journal of Rare Earths2009，27，1： | 8 |
| 3 | Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina显示文摘AIM To investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. METHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical visit.RESULTS A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). The prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P < 0.0001). Accordingly, a higher prevalence of diabetes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P < 0.0001). Lower median AFP values at HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher mortality.CONCLUSION The growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications. | Federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva | 2018 | World Journal of Hepatology2018，10，1： | 4 |
| 4 | Applications of genomics in NSCLC显示文摘 | Rosell R Cobo M Isla D | | 0，，2： | 2 |
| 5 | 显示文摘 | COBO M SILVA M | 1999 | J Chromatogr: A1999，848，12： | 1 |
| 6 | ERCC1 mRNA-based ran- domized phase Ⅲ trial of docetaxel doublets with cisplatin or gemcitabine in stage Ⅳ non-small-cell lung cancer patients显示文摘 | Rosell R Cobo M Massuti B | 2005 | J Clin Oncol2005，23，16： | 1 |
| 7 | Two-microphone multi-speaker localization based on a laplacian mixture model显示文摘 | Cobos M Lopez J J and Martinez D | 2010 | Digital Signal Processing2010，21，1： | 1 |
| 8 | Maturation in vitro of human oocytes from unstimulatedcycles : selection of the optimal day for ovum retrieval based on follicular size 显示文摘 | Cobo AC Requena A Neuspiller F | 1999 | Hum Reprod1999，14，7： | 1 |
| 9 | Albendazole Plus Praziquantel Versus Albendazole Alone as a Pre-operative Treatment in Intra-abdominal Hydatisosis Caused by Echinococcus granulosus显示文摘 | Cobo F Yarnoz C Sesma B | 1998 | Trop Med Int Health1998，3，6： | 1 |
| 10 | Hilbert-Huang adysis of BWR neutron detector signals: Application to DR calculation and to corrupted signal analysis显示文摘 | Montesinos M E Munoz - Cobo L Perez C | 2003 | Annals of Nuclear Energy2003，30，： | 1 |
| 11 | Analysis of mortality and risk factors associated with native valve endocarditis in drug users: The importance of vegetation size显示文摘 | Pilar Martín-Dávila Enrique Navas Jesús Fortún Jose Luis Moya Javier Cobo Vicente Pintado Carmen Quereda Manuel Jiménez-Mena Santiago Moreno | 2005 | American Heart Journal2005，，5： | 1 |
| 12 | Microperforated insertion units: An alternative strategy to design microperforated panels显示文摘 | Jaime Pfretzschner Pedro Cobo Francisco Simón María Cuesta Alejandro Fernández | 2005 | Applied Acoustics2005，，1： | 1 |
| 13 | Chia seeds: microstructure, mucilage extraction and hydration显示文摘 | Munoz LA Cobos A Diaz O Aguilera JM | 2012 | J Food Eng2012，108，1： | 1 |
| 14 | Thrombectomy within 8 hours after symptom onset in ischemic stroke显示文摘 | Jovin TG Chamorro A Cobo E | 2015 | N Engl J Med2015，372，： | 1 |
| 15 | The cylindrical titanium mesh cage for treatment of a long hone se~nental defect: description of a new technique and report of two cases显示文摘 | Cobos JA lJndsey RW Gug~a Z | 2000 | J Orthop Trauma2000，14，1： | 1 |
| 16 | Role of the p38MAPK pathway in cisplatin-based therapy显示文摘 | Losa J H Parada Cobo C Viniegra JG | 2003 | Oncogene2003，22，26： | 1 |
| 17 | Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitri- fied by the cryotop method显示文摘 | Cobo A Kuwayama M Perez S | 2008 | Fertil Steril2008，89，6： | 1 |
| 18 | Mesenchy- real stem ceils expressing vasoactive intestinal peptide ameliorate symptoms in a model of chronic multiple scleros显示文摘 | COBO M ANDERSON P BENABDELLAH K | 2013 | Cell Trans- plantation2013，22，5： | 1 |
| 19 | Treatment with amniopatch of premature rupture of membranes after first-trimester chorionic villus sampling显示文摘 | Cobo T Borrell A Fortuny A | | 0，，11： | 1 |
| 20 | Single phase power factor correction: a survey显示文摘 | Garcia O Cobos J A Prieto R | 2003 | IEEE Transactions on Power Electronics2003，18，3： | 1 |
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