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| 1 | Cytoreduction and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from pseudomixoma peritonei显示文摘AIM:To investigate the most important aspects of hyperthermic intraperitoneal chemotherapy (HIPEC) that has been accepted as the standard treatment for pseudomyxoma peritonei (PMP),with special regard to morbidity,overall survival (OS) and disease free survival (DFS) over 10 years. METHODS:Fifty-three patients affected by PMP underwent cytoreduction (CCR) and HIPEC with a 'semi-closed' abdomen technique in our institution. The peritonectomy procedure and completeness of CCR were classifi ed according to Sugarbaker criteria. Preoperative evaluation always included thoracic and abdominal CT scan to stage peritoneal disease and exclude distant metastases. Fifty-one patients in our series were treated with a protocol based on administration of cisplatinum 100 mg/m2 plus mitomycin C 16 mg/m2,at a temperature of 41.5℃ for 60 min. Anastomoses were always performed at the end of HIPEC. The mean duration of surgery was 12 h including HIPEC. Continuous monitoring of hepatic and renal functions and hydroelectrolytic balance was performed in the postoperative period. RESULTS:Twenty-four patients presented with postoperative complications:surgical morbidity was observed in 16 patients and 6 patients were re-operated. All complications were successfully treated and no postoperative deaths were observed. Risk factors for postoperative morbidity were considered to be gender,age,body surface,duration of surgery,Peritoneal Cancer Index (PCI) and tumor residual value (CC score). No statistically signifi cant correlation was found during the multivariate analysis:only the CC score was statistically significant. The OS in our experience was 81.8%,with a DFS of 80% at 5 years and of 70% at 10 years. CONCLUSION:In our experience,even if HIPEC combined with cytoreductive surgery involves a high risk of morbidity,postoperative complications can be resolved favorably in most cases with correct patient selection and adequate postoperative care,thus minimizing mortality. The association of CCR and HIPEC can be considered as the standard treatment for PMP. The OS and DFS results confi rm the validity of this combined approach for the treatment of this rare neoplasm. The impact of preoperative chemotherapy on OS,in our opinion,is due to a major aggressiveness of tumors in treated patients. | Tommaso Cioppa Marco Vaira Camilla Bing Silvia D'Amico Alessandro Bruscino Michele De Simone | 2008 | World Journal of Gastroenterology2008，14，44： | 13 |
| 2 | Treatment of Peritoneal Carcinomatosis by Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemoperfusion (IHCP): Postoperative Outcome and Risk Factors for Morbidity显示文摘 | Franco Roviello Daniele Marrelli Alessandro Neri Daniela Cerretani Giovanni Manzoni Corrado Pedrazzani MD Tommaso Cioppa MD Giacomo Nastri MD Giorgio Giorgi Enrico Pinto | 2006 | World Journal of Surgery2006，，11： | 3 |
| 3 | Spatial Variations in Particle Size and Magnetite Concentration on Cedar Beach:Implications for Grain-Sorting Processes,Western Lake Erie,Canada显示文摘这研究在雪松沙滩上在集中,谷物尺寸和重矿物质集合检验了空间变化(湖伊利湖,加拿大) 。在沙滩上在场的重充实矿物质的、黑暗微红的沙的磁性的研究显示出那个磁铁矿(~ 150 m ) 是主导的磁性的矿物质。地表的磁性的危险性价值定义三个地区:向著湖的区域结束到水线(地区 1 ) ,上面冲激地区(地区 2 ) 和这个区域朝陆地上面冲激地区(地区 3 ) 。地区 2 显示出最高的体积和集体危险性(,) 并且更小的谷物尺寸的最高集体的百分比(< 250 m ) 在体积沙样品的部分。危险性(即并且)价值减少了,谷物尺寸从地区 2 lakewards 变粗(进地区 1 )并且朝陆地(进地区 3 ),并且与重矿物质集合的分发相关,最可能思考的优先的分离大,由沿着并且越过沙滩的波浪和水流的不太稠密的粒子。雪松沙滩的侵蚀的西方的节比增大包括磁铁矿,和更好的沙谷物尺寸显示出重矿物质的高得多的集中东方节,建议磁性的技术能被用作沿着敏感海岸线区域检验侵蚀的一个快速的、划算的方法。 | ZHANG Shuwei Maria T. CIOPPA ZHANG Shihong | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 3 |
| 4 | Facing Classification Problems with Particle Swarm Optimization显示文摘 | Faleo I D Cioppa A D Tarantino E | 2007 | Applied Soft Computing2007，7，3： | 1 |
| 5 | Efficient nearly orthogonal and space-filling latin hypereubes 显示文摘 | Cioppa T M Lucas T W | 2007 | Technometrics2007，49，1： | 1 |
| 6 | Cytoplasmic inhibi-tion of carotenoid biosynthesis with virus-derived RNA 显示文摘 | KumagaiM H Donson J Della - Cioppa G | 1995 | ProcNatl Acad Sci USA1995，92，5： | 1 |
| 7 | Trivalent and quadrivalent MF59 (R)-adjuvanted influenza vaccine in young children: a dose- and schedule-finding study 显示文摘 | DELLA CIOPPA G VESIKARI T SOKAL E | 2011 | Vaccine2011，29，47： | 1 |
| 8 | Proceedings of geofluids V, fifth international confer- ence on fluid evolution, migration and interaction in Sedimentary basins and orogenic belts, Windsor, On- tario, Canada显示文摘 | SAMSON I M CIOPPA M T SYMONS D T A | 2006 | Journal of Geochemical Explora- tion2006，89，13： | 1 |
| 9 | Effects of hydroxymethylglutaryl coenzyme a reductase inhibitors simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury显示文摘 | Indofi C Cioppa A Stabile E | 2000 | J Am Coll Cardiol2000，35，1： | 1 |
| 10 | Evaluation of the biode- gradable peripheral igaki-tamai stent in the treatment of de novo lesions in the superficial femoral artery:the gaia study显示文摘 | Werner M Micari A Cioppa A | 2014 | JACC Cardiovase Interv2014，7，3： | 1 |
| 11 | Fa- cing classification problems with particle swarm optimi- zation 显示文摘 | De FALCO I Della CIOPPA A TARANTINO E | 2007 | Applied Soft Computing2007，7，3： | 1 |
| 12 | Facing classification problems with particle swarm optimization 显示文摘 | FALCO D CIOPPA A D TARANTINO E | 2007 | Applied Soft Computing2007，，7： | 1 |
| 13 | Facing classification problems with Particle Swarm Optimization 显示文摘 | I De Falco A Della Cioppa E Tarantino | 2007 | Applied Sott Computing (S1568-4946)2007，7，3： | 1 |
| 14 | Where are the niches? Dynamic fitness sharing 显示文摘 | CIOPPA A D STEFANO C D MARCELLI A | 2007 | IEEE Transactions on Evolutionary Computation2007，11，4： | 1 |
| 15 | Radiation dose exposure during cardiac and peripheral arteries catheteisation显示文摘 | Kocinaj D Cioppa A Ambrosini G | 2006 | INT J Cardiol2006，113，2： | 1 |
| 16 | Military application of agent-based simulation显示文摘 | Thomas M Cioppa Thomas W Lucas Susan M Sanchez | 2004 | WSC2004，2004，： | 1 |
| 17 | Percutaneous femoral artery angioplasty with stent-in-stent technique and tiroflban administration显示文摘 | Ambrosini V Battaglia S Cioppa A | 2002 | Invasive Cardiol2002，14，10： | 1 |
| 18 | Evaluation of particle swarm optimization effectiveness in classification 显示文摘 | FALCO I CIOPPA A TARANTINO E | 2006 | Lecture Notes in Computer science2006，3849，： | 1 |
| 19 | Effects of bydroxymethylghltaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro arid neointimal fbrmation in vivo aftei vascular injury 显示文摘 | hldolil C Cioppa A Stabile E | 2000 | J Am Coll Cardiol2000，35，1： | 1 |
| 20 | Management of pseudomyxoma peritonei by cytoreduction plus hipec (hyperthermic intraperitoneal chemotherapy): results analysis of a twelve-year experience显示文摘 | Vaira M Cioppa T De Marco G | 2009 | In Vivo2009，23，4： | 1 |
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