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| 1 | Circulating adhesion molecules in patients with virus-related chronic diseases of the liver显示文摘AIM: In the inflammatory state, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) play a key role in promoting migration of immunological cells from the circulation to target site.Aim of our study was to investigate soluble forms of these molecules in patients with virus-related chronic liver diseases, to assess their behavior in different pathologies and correlation with severity of liver damage.METHODS: Circulating ICAM-1 and VCAM-1 were assayed by EIA commercial kits (R&D System Co.,Abington, UK) in 23 patients with chronic active hepatitis (CH), 50 subjects affected by liver cirrhosis (LC) and 15 healthy controls comparable for sex and age. In patients, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also detected by autoanalyzer.RESULTS: LC patients had significantly higher ICAM-1 values than CH patients (38.56±7.4 ng/mL vs 20.89±6.42 ng/mL; P<0.001) and these ones had significantly higher values than controls (12.92±1.08 ng/mL; P<0.001). In CH group, ICAM-1 levels were significantly related to inflammatory activity (P= 0.041) and ALT values (r= 0.77;P<0.05). VCAM-1 values were significantly increased only in LC patients (P<0.001) and related to severity of liver impairment.CONCLUSION: These findings suggest that the determination of serum ICAM-1 can be considered as an additional useful marker of hepatocellular necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator of liver fibrogenesis and severity of disease in cirrhosis. | Cosimo Marcello Bruno Claudio Sciacca Danila Cilio Gaetano Bertino Anna Elisa Marchese Gaetana Politi Lucia Chinnici | 2005 | World Journal of Gastroenterology2005，11，29： | 19 |
| 2 | Plasma erythropoietin levels in anaemic and non-anaemic patients with chronic liver diseases显示文摘AIM: To investigate the serum erythropoietin (Epo) levels in patients with chronic liver diseases and to compare to subjects with iron-deficiency anaemia and healthy controls.METHODS: We examined 31 anaemic (ALC) and 22 non-anaemic (NALC) cirrhotic patients, 21 non-anaemic subjects with chronic active hepatitis (CAH), 24 patients with iron-deficiency anaemia (ID) and 15 healthy controls. Circulating Epo levels (ELISA; R&D Systems, Europe Ltd, Abingdon,UK) and haemoglobin (Hb) concentration were determined in all subjects.RESULTS: Mean±SD of Epo values was 26.9±10.8 mU/mL in ALC patients, 12.5±8.0 mU/mL in NALC subjects,11.6±6.3 mU/mL in CAH patients, 56.4±12.7 mU/mL in the cases of ID and 9.3±2.6 mU/mL in controls. No significant difference (P>0.05) was found in Epo levels between controls, CAH and NALC patients. ALC individuals had higher Epo levels (P<0.01) than these groups whereas ID subjects had even higher levels (P<0.001) than patients suffering from ALC.CONCLUSION: Increased Epo values in cirrhotics, are only detectable when haemoglobin was lesser than 12 g/dL.Nevertheless, this rise in value is lower than that observed in anaemic patients with iron-deficiency and appears blunted and inadequate in comparison to the degree of anaemia. | Cosimo MarcelloBruno Sergio Neri ClaudioSciacca Gaetano Bertino Pietro DiPrima Danila Cilio Luciano Caruso Raffaello Cristaldi Rinaldo Pellicano | 2004 | World Journal of Gastroenterology2004，10，9： | 5 |
| 3 | Timing of ketogenic di- etinitiation in an experimental epilepsy model显示文摘 | Su SW Cilio MR Sogawa Y | 2000 | Brain Res Dev Brain Res2000，125，12： | 1 |
| 4 | Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes 显示文摘 | AGARDH C D CILIO C M LETHAGEN A | 2005 | J Diabetes Complications2005，19，4： | 1 |
| 5 | Long-term effects of status epilepticus in the immature brain are specific for age and model显示文摘 | Cilio MR Sogawa Y Cha BH | 2003 | Epilepsia2003，44，4： | 1 |
| 6 | Intravenous leveti- racetam terminates refractory status epilepticus in two patients with migrating partial seizures in infancy显示文摘 | Cilio MR Bianchi R Balestri M | 2009 | Ep- ilepsy Res2009，86，1： | 1 |
| 7 | Long-term effects of status epilepticus in the immature brain are specific for age and model显示文摘 | Cilio MR Sogawa Y Cha BH | 2003 | Epilepsia2003，44，4： | 1 |
| 8 | Clinical evidence for the safety of GAD65 immunomodulation in adultonset autoimmune diabetes显示文摘 | Agardh CD Cilio CM Lethagen A | 2005 | J Diabetes Complications2005，19，： | 1 |
| 9 | Long-term effects of neonatal seizures:a behavioral,electrophysiological and histological study显示文摘 | Huang L Cilio MR Silveira DC | 1999 | Brain Res Dev Brain Res1999，118，12： | 1 |
| 10 | Sleep-wake cycling in a neonate admitted to the NICU:A video-EEG case study during hypothermia treatment显示文摘 | Axelin A Cilio MR Asunis M | 2013 | J Perin Neonatal Nurs2013，27，3： | 1 |
| 11 | Differential glu- cose-regulation of microRNAs in pancreatic islets of non- obese type 2 diabetes model Goto-Kakizaki rat显示文摘 | Esguerra JL Bolmeson C Cilio CM | 2011 | PLoS One2011，6，18： | 1 |
| 12 | Differences in islet-enriched miRNAs in healthy and glucose intolerant human subjects显示文摘 | Bolmeson C Esguerra JL Salehi A Speidel D Eliasson L Cilio CM | 2011 | Biochem Biophys Res Commun2011，404，1： | 1 |
| 13 | Clinical evidence for safety,efficacy,and autoimmunomodulation by a novel therapy显示文摘 | Cilio C M Lethagen A | 2005 | J Diabetes Complications2005，19，4： | 1 |
| 14 | Long term effects of status epilepticus in the immature brain are specific for age and model 显示文摘 | Cilio MR Sogawa Y Cha BH | 2003 | Epilesia2003，44，： | 1 |
| 15 | Long-term effects of status epilepticus in the immature brain are specific for age and model显示文摘 | Cilio MR Sogawa Y Cha BH | 2003 | Epilepsia2003，44，4： | 1 |
| 16 | Long - term effects of status epilepticus in the immature brain are specific for age and model 显示文摘 | Cilio M R Sogawa Y Cha B H | 2003 | Epilepsia2003，44，4： | 1 |
| 17 | Unusual cyclosporine-related neurological complications in recipients of liver transplants显示文摘 | Cilio MR Danhaive O Gadisseux JF | 1993 | Arch Dis Child1993，68，： | 1 |
| 18 | Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes显示文摘 | Agardh CD Cilio CM Lethagen A | 2005 | J Diabetes Complications2005，19，4： | 1 |
| 19 | Long - terra effects of status epilepticus in the immature brain are specific for age and model显示文摘 | Cilio MR Sogawa Y Cha BH | 2003 | Epilepsia2003，44，4： | 1 |
| 20 | Long - term effects of status epilepticus in the immature brain are specific for age and model显示文摘 | Cilio MR Sogawa Y Cha BH | 2003 | Epilepsia2003，44，4： | 1 |
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