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| 1 | Upper esophageal sphincter abnormalities are strongly predictive of treatment response in patients with achalasia显示文摘AIM: To investigate the relationship between upper esophageal sphincter abnormalities achalasia treatment METHODS: We performed a retrospective study of 41 consecutive patients referred for high resolution esophageal manometry with a final manometric diagnosis of achalasia. Patients were sub-divided by presence or absence of Upper esophageal sphincter(UES) abnormality, and clinical and manometric profiles were compared.Correlation between UES abnormality and sub-type(i.e.,hypertensive, hypotensive or impaired relaxation) and a number of variables, including qualitative treatment response, achalasia sub-type, co-morbid medical illness,psychiatric illness, surgical history, dominant presentingsymptom, treatment type, age and gender were also evaluated.RESULTS: Among all 41 patients, 24(58.54%) had a UES abnormality present. There were no significant differences between the groups in terms of age, gender or any other clinical or demographic profiles. Among those with UES abnormalities, the majority were either hypertensive(41.67%) or had impaired relaxation(37.5%) as compared to hypotensive(20.83%), although this did not reach statistical significance(P = 0.42). There was no specific association between treatment response and treatment type received; however, there was a significant association between UES abnormalities and treatment response. In patients with achalasia and concomitant UES abnormalities, 87.5% had poor treatment response, while only 12.5% had favorable response. In contrast, in patients with achalasia and no UES abnormalities, the majority(78.57%) had good treatment response, as compared to 21.43% with poor treatment response(P = 0.0001). After controlling for achalasia sub-type, those with UES abnormality had 26 times greater odds of poor treatment response than those with no UES abnormality(P = 0.009). Similarly, after controlling for treatment type, those with UES abnormality had 13.9 times greater odds of poor treatment response compared to those with no UES abnormality(P = 0.017).CONCLUSION: The presence of UES abnormalities in patients with achalasia significantly predicted poorer treatment response as compared to those with normal UES function. | Simon C Mathews Maria Ciarleglio Yamile Haito Chavez John O Clarke Ellen Stein Bani Chander Roland | 2014 | World Journal of Clinical Cases2014，2，9： | 5 |
| 2 | Reduced mitochondrial respiration in mouse cerebral cortex during chronic hypoxia显示文摘 | Chavez J C Pichiule P Boero J | 1995 | Neurosci Lett1995，193，3： | 2 |
| 3 | Poultry slaughter wastewater treatment with an up-flow anaerobic sludge blanket(UASB)reactor显示文摘 | CHAVEZ P C CASTILLO L R DENDOOVEN L | 2005 | Bioresource Technology2005，96，： | 1 |
| 4 | Size paradigms in copepod communities: a re examination显示文摘 | HOP('ROFT R R ROFF J C and CHAVEZ F P | 2001 | Hydrobiologia2001，，： | 1 |
| 5 | Comparison of three different method to merge multiresolution and multispectral data,Landsat TM and SPOT panchromatic 显示文摘 | Sides S C Anderson J A | 1991 | Photogrammetric Engineering & Remote Sensing1991，57，3： | 1 |
| 6 | Joint interpretation of gravity and magnetic data over axial symmetric bodies with application to the Darnley Bay anomaly显示文摘 | CHAVEZ R E BAILEY R C GARLAND G D | 1987 | Nwt Canada Geophysical Prospecting1987，35，： | 1 |
| 7 | Genetic and phenotypic variation across a hybrid zone between ecologically divergent tree squirrels (Tamiasciurus) 显示文摘 | Chavez A S Saltzberg C J Kenagy G J | 2001 | Molecular Ecology2001，20，6： | 1 |
| 8 | Functional characterization of multiple domains in- volved in the subcellular localization of the hematopoi- etic Pbx interacting protein (HP1P) 显示文摘 | Abramovich C Chavez E A Lansdorp P M | 2002 | Oncogene2002，21，44： | 1 |
| 9 | Compari-son of three different methods to merge multiresolutionand multispectral data:TM&SPOT pan显示文摘 | CHAVEZ P S SIDES S C ANDERSON J A | 1991 | Photoga-mmetric Engineering and Remote Sensing1991，57，3： | 1 |
| 10 | Time of birth and the risk of neonatal death显示文摘 | Gould J B Qin C Chavez G | 2005 | Obstet Gynecol2005，106，20： | 1 |
| 11 | Drying of municipal sewage sludge:From a laboratory scale batch indirect dryer to the paddle dryer显示文摘 | Arlabosse P Chavez S Prevot C | 2005 | Brazilian Journal of Chemical Engineering2005，22，2： | 1 |
| 12 | Comparison of three different methods to merge multiresolution and multispeetral data显示文摘 | Chavez P R Sides S C Anderson J A | 1991 | Photogrammetric Engineering and Remote Sensing1991，57，3： | 1 |
| 13 | The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia显示文摘 | AGANI F H PICHIULE P CHAVEZ J C | 2000 | J Biol Chem2000，275，35： | 1 |
| 14 | Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage显示文摘 | CHAVEZ L JOZEFCZUK J GRIMM C | 2010 | Genome Res2010，20，10： | 1 |
| 15 | Pharmaeokinetics of lithium in healthy volunteers after exposure to high altitude 显示文摘 | Arancibia A Paulos C Chavez J | 2003 | Int J Clin Pharmacol Ther2003，41，5： | 1 |
| 16 | Expression of hypoxia-inducible factor-1alpha in the brain of rats during chronic hypoxia显示文摘 | Chavez J C Agani F Pichiule P | 2000 | J Appl Physiol2000，89，5： | 1 |
| 17 | GS-9620,an oral agonist of Toll-like receptor-7,induces prolonged suppression of hepatitis B virus in chronically infected chimpanzees显示文摘 | Lanford R E Guerra B Chavez D Frey C R Ohmstede C Hesselgesser J Kearney B Moorehead L Subramanian G M McHutchison J G | 2013 | Gastroenterology2013，144，7： | 1 |
| 18 | Arid land monitoring using Landsat albedo different images 显示文摘 | ROBINOVE C J CHAVEZ P S | 1981 | Remote Sensing of Environment1981，11，2： | 1 |
| 19 | Cross-listing and Liquidity in Emerging Market Stocks显示文摘 | Silva A C Chavez G A | 2008 | Journal of Banking & Finance2008，32，3： | 1 |
| 20 | New high-nitrogen materials based on nitroguanyl-tetra-zines:Explosive properties,thermal decomposition and combustion studies显示文摘 | Chavez D E Tappan B C Hiskey M A | 2005 | Propellants Explosives Pyrotechnics2005，30，6： | 1 |
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