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| 1 | Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN显示文摘AIM To investigate the pathogenic effect ofSEB and D-GalN on liver and the protection ofcyclosporin A, the relationship between hepaticapoptosis and necrosis and the possiblemechanism of acute hepatic necrosis.METHODS After staphylococcal enterotoxin B(SEB ) mixed with D--galactosamine (D-GaiN )were injected intraperitoneally into Balb/c miceand those previously treated with cyclosporin A,blood samples were collected and livers wereisolated at 2, 6, 12 and 24 h. Patterns othepatocellular death were studiedmorphologically and biochemically, circulatingcytokines (TNF-a, IFN--y ) and mice mortalitywithin 24h was assessed.RESU’LTS The SEB could induce the typicalapoptotic changes of hepatocytes, the D-GaiNcould induce hepatocytes apoptosis anddegeneration at the same time, and the micehaving received the SEB + D-GaiN injectionsdeveloped apoptosis at 2 and 6 h, but after 12 hhepatocytes were characterized by severein jury, whereas all the examinations in thecyclosporin A treated mice were normal.CONCLUSION Hepatic cell apoptosis might berelated to necrosis, and massive hepatocyteapoptosis is likely the initiating step of acutehepatic necrosis in mice. The effects induced bySEB and D--GaiN on hepatocytes might bemediated by T cells, and could be prevented bycyclosporin A. | Yin, T Tong, SQ Xie, YC Lu, DY | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 2 | Immunological role of indoleamine 2,3-dioxygenase in rat liver allograft rejection and tolerance显示文摘 | Lin YC Chen CL Nakano T | 2008 | J Gastroenterol Hepatol2008，23，72： | 1 |
| 3 | Role of PKC in the novel synergistic action of urotensin Ⅱ and angiotensin Ⅱ and in urotensin Ⅱ-induced vasoconstriction显示文摘 | Ding YJ Zhu YZ Shi Y Yao T Zhu YC | 2007 | Am J Physiol Heart Circ Physiol2007，292，1： | 1 |
| 4 | Cortieosteroids reduee IL-6 in ASM cells via up regulation of MKP-1显示文摘 | Quante T Ng YC Ramsay EE | 2008 | Am J Respir Cell Mol Biol2008，39，2： | 1 |
| 5 | Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells显示文摘 | Zhou S Lien YC Shuvaeva T | 2013 | Int J Biochem Cell Biol2013，45，2： | 1 |
| 6 | A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nucle- ar chaperone in the activation of STAT transcription factors显示文摘 | Kawashima T Bao YC Minoshima Y | 2009 | Mol Cell Biol2009，29，7： | 1 |
| 7 | Using multi-detector row CT in neonates with complex congenital heart disease to replace diagnostic cardiac catheterization for anatomic investigation:initial experiences in technical and clinical feasibility显示文摘 | Lee T Tsai IC Fu YC | 2006 | Pediatr Radiol2006，36，12： | 1 |
| 8 | Report on the distribution, population, and ecology of the Yunnan snub-nosed monkey( Rhinopithecus bieti) 显示文摘 | Long YC Kirkpatrick RC Zhong T | 1994 | Primates1994，35，： | 1 |
| 9 | Genetic etiology study of the non-syndromic deafness in Chinese Hans by targeted next-generation sequencing显示文摘 | Yang T Wei XM Chai YC | 2013 | Orphanet J of Rare Dis2013，8，： | 1 |
| 10 | Expression of survivin in invasive pituitary adenoma显示文摘 | Zhang YC Gao J Xin T | 2008 | Saudi Med J2008，29，11： | 1 |
| 11 | Social organization and range use in the Yunnan snub-nosed monkey Rhinopithecus bieti 显示文摘 | Kirkpauick RC Long YC Zhong T | 1998 | Int JPrimatol1998，19，： | 1 |
| 12 | Lysophosphatidic acid signaling may initiate fetal hydrocephalus 显示文摘 | Yung YC Mutoh T Lin ME | 2011 | Sci Transl Med2011，3，99： | 1 |
| 13 | Pleural infection:changing bacteriology and its implications显示文摘 | Lisboa T Waterer GW Lee YC | 2011 | Respirology2011，16，4： | 1 |
| 14 | A preliminary investigation ofthe association between serum uric acid andimpaired renal function显示文摘 | Chen YC Su C T Wang S T | 2009 | Chang Gung Med J2009，32，1： | 1 |
| 15 | Expression of survivin in invasive pituitary adenoma 显示文摘 | Zhang YC Gao J Xin T | 2008 | Saudi Med J2008，29，： | 1 |
| 16 | The human obesity gene map: the 2005 update 显示文摘 | Rankinen T Zuberi A Chagnon YC | 2006 | Obesity ( Silver Spring)2006，14，： | 1 |
| 17 | Influence of genetic and environmental factors on the immunogenicity of Hib vaccine in Gambian twins显示文摘 | Lee YC Newport MJ Goetghebuer T | 2006 | Vaccine2006，24，25： | 1 |
| 18 | Using multidetector-row CT in neonates with complex congenital heart disease to replace diagnostic cardiac catheterization for anatomical investigation: initial experiences in technical and clinical feasibility 显示文摘 | Lee T Tsai IC Fu YC | 2006 | Pediatr Radiol2006，36，12： | 1 |
| 19 | The human obesity gene map:the 2002 update显示文摘 | Chagnon YC Rankinen T Snyder EE | 2003 | Obes Res2003，11，3： | 1 |
| 20 | Distribution of human papilloma-virus genotypes among cervical intraepithelial neoplasia and inva-sive cancers in Macao显示文摘 | Hlaing T Yip YC Nqai KL | 2010 | Med Virol2010，82，9： | 1 |
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