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| 1 | 左心质量与脑磁共振成像和认知功能的关系显示文摘左心室质量(1eft ventricularmass,LVM)被证实可以作为长期暴露于数个危险因素下时造成的靶器官损害的评估标准。有关中年LVM和晚期认知表现之间联系的资料很少。纳入StrongHeart研究(SHS,1993—1995)及其附属的CDCAI(脑血管病及其对美国印第安人的影响)研究(2010—2013)中721名成年研究对象(平均基础年龄56岁),这些人群心血管病风险较高。 | 黄洁 叶鹏 Haring B Omidpanah A Suchy Dicey AM Best LG Verney SP Shibata DK Cole SA Ali T Howard BV Buchwald D Devereux RB | 2017 | 中华高血压杂志2017，25，10： | 4 |
| 2 | 被激光损伤软骨释放的凋亡因子诱导软骨细胞凋亡的研究显示文摘目的探讨组织损伤后凋亡信号怎样促进细胞的死亡进程。方法在激光照射后猪软骨块置培液中,在不同时间(3、6、9、12、24 h)收集的培液,即实验条件培养液(TCM),从未经激光照射的软骨块培液取得的为对照条件培养液(CCM)。软骨块继续培养28 d,用聚焦显微镜评价其受损区的进展。分离的软骨细胞单层放于 TCM、CCM 或正常培养液(NM)培养,阳性对照组单层细胞经紫外线照射10 min 后继续用正常培养液培养,培养24 h 后,收集细胞并用荧光标记物染色,经流式细胞仪分析。结果所有经 TCM 培养的细胞显现半胱氨酸蛋白水解酶(caspase)-3阳性、CMXRos 和一氧化氮信号减少或失去;经 CCM 或 NM 培养的细胞显现 caspase-3阴性、CMXRos 和一氧化氮信号完好;阳性对照组细胞显现 Caspase-3和 CMXRos 均阳性、一氧化氮信号减少或失去,代表处于凋亡早期的细胞。不同 TCM 浓度(100%、50%、25%、12.5%)和时间(0.5、1、3、9、12 h)对细胞作用后,所有细胞均呈现 caspase-3阳性、CMXRos 和一氧化氮信号减少或失去。结论激光照射受损软骨释放凋亡因子,可诱导单层细胞死亡。 | 郑敏 Grogan SP Schaffner T Mainil-Varlet P | 2007 | 中华医学杂志2007，87，21： | 3 |
| 3 | 农村人口亚临床动脉粥样硬化及其与冠状动脉疾病危险因素的关系显示文摘在美国〈65岁的人群中,包括无症状的个体在内,每年有超过15万的心血管事件发生。冠状动脉钙化(coronary artery calcium,CAC)是冠状动脉疾病(coronary artery disease,CAD)的亚临床指标,可提高无症状个体的危险分层。该研究旨在评估农村人口的CAC发生率,确定CAD传统危险因素和CAC评分之间的相关性。方法:2011年1月至2012年12月,研究人员对来自阿巴拉契亚中部地区无症状个体的CAC情况进行筛查,根据Agatston钙化评分将受试者分为4种CAC水平:无(CAC=0),轻度(CAC=1~99),中度(CAC=100~399)和重度(CAC≥400)。 | 刘莉 叶鹏 Mamudu HM Paul T Veeranki SP Wang L Panchal HB Budoff M | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 4 | Surgical stress and cytoskeletal changes in lens epithelial cells following manual and femtosecond laser-assisted capsulotomy显示文摘AIM:To study the effect of mechanical stress on the cytoskeleton in lens epithelial cells following conventional phacoemulsification surgery(CPS)and femtosecond laserassisted cataract surgery(FLACS).METHODS:The cytoskeleton of the epithelial cells of the anterior lens capsules(ALC)removed by CPS and FLACS was examined by immunohistochemistry.Expression of the intermediate filament,glial fibrillary acidic protein(GFAP),and glutamine synthetase(GS)immunoreactivity were detected.In order to map the actin network of cells,fluorescently labeled phalloidin was used.The samples were examined using confocal laser scanning microscopy.RESULTS:GFAP expression was visible in a larger number of the epithelial cells after CPS compared to FLACS.In CPS sample’s epithelial cells,GFAP immunoreactivity indicated robust morphological change.Regarding the actin filaments,the presence of tubular elements connecting epithelial cells,regular actin pattern and marked cortical network after CPS were found.Following FLACS,the actin cytoskeleton of the epithelial cells remained densely structured,and the tubular elements were undetectable,however,the above-mentioned regular actin pattern and the marked cortical network were visible.CONCLUSION:The conventional removal of the ALC induces more robust changes of the cytoskeleton of the lens epithelial cells. | ANDrea Krisztina Sükosd Krisztina Szabadfi Edina Szabó-Meleg Beáta Gáspár Pavel Stodulka Gyorgy SétálóJr Róbert Gábriel Miklós Nyitrai Zsolt Biró Hajnalka Abrahám | 2020 | International Journal of Ophthalmology(English edition)2020，13，6： | 2 |
| 5 | E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas显示文摘 | Tamura G Yin J Wang S Fleisher AS Zou T Abraham JM Kong D Smolinski KN Wilson KT James SP Silverberg SG Nishizuka S Terashima M Motoyama T Meltzer SJ | | 0，，： | 2 |
| 6 | The mitochondrial permea-bility transition initiates autophagy in rat hepatocytes显示文摘 | Elmore SP Qian T Grissom SF | 2001 | FASEB J2001，15，12： | 1 |
| 7 | Does needle insertion site affact discography results retrospective analysis 显示文摘 | Cohen SP Lark in T Fant GV | 2002 | Spine2002，27，20： | 1 |
| 8 | EC1 显示文摘 | Yi T Lee E H Ahn Y Ct Novel biodegradation pathways of cyclohexane by Rhodococcus sp | 2011 | Journal of Hazardous Materials2011，191，13： | 1 |
| 9 | Pathologic analysis of sentinel and nonsentinel lymph nodes in breast carcinoma显示文摘 | WEAVER DL ASHIKAGA T HARLOVO SP | 2000 | Cancer2000，88，5： | 1 |
| 10 | p16 (CDKN2/cyclin-depdendent Kinase-4 Inhibitor/multiple Tumor Supp-ressor-1) Gene is Not Altered in Uterine Cervical Carcinomas or cell lines显示文摘 | Miller CW Wilczynski SP | 1996 | Mod Pathol1996，9，1： | 1 |
| 11 | Robotic cardiac surgery: advanced minimally invasive technology hindered by barriers to adoption 显示文摘 | Athanasiou T Ashrafian H Rowland SP | 2011 | Future Cardiol2011，7，4： | 1 |
| 12 | Evaluation of cervical spine fracture in the elderly= can we trusl our physical examination? 显示文摘 | Ooode T Young A Wilson SP | 2014 | Am Surg2014，80，18： | 1 |
| 13 | An evaluation of teaching intervention to improve the practice of endotracheal suctioning in intensive care units显示文摘 | Day T Wainwright SP Wilson-Barnett J | 2001 | Journal of Clinical Nursing2001，10，： | 1 |
| 14 | Tumor-associated macrophages and survival in classic Hodgkin's lymphoma显示文摘 | Steidl C Lee T Shah SP | 2010 | N Engl J Med2010，362，： | 1 |
| 15 | The concept of damage control:extending the paradigm to emergency general surgery显示文摘 | Stawicki SP Brooks A Bilski T | 2008 | Injury2008，39，1： | 1 |
| 16 | Does needle in- sertion site affect diskography results? A retrospec- tive analysis显示文摘 | Cohen SP Larkin T Fant GV | 2002 | Spine2002，27，20： | 1 |
| 17 | Regulation if the angiotensin type-1 receptor by antisense oligonueleotides occurs through an RNase Htype mechanism显示文摘 | Ho SP Bao YJ Lesher T | 1999 | Molecular brain research1999，65，： | 1 |
| 18 | Regulation of the angiotensin type-1 receptor by antisense oligonucleotides occurs through an Rnase H-type mechanism显示文摘 | Ho SP Bao Y Lesher T | 1999 | Brain Res Mol Brain Res1999，65，1： | 1 |
| 19 | Development of a multiple-drug delivery implant for intraocular management of显示文摘 | Zhou T Lewis H Foster RE Schwendeman SP | 1998 | J Control Release1998，55，： | 1 |
| 20 | The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy 显示文摘 | Lemasters J J Nieminen AL Qian T Trost LC Elmore SP Nishimura Y | 1998 | Biochim Biophys Acta1998，1366，12： | 1 |
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