|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cyclosporin A protects Balb/c mice from liver damage induced by superantigen SEB and D-GaIN显示文摘AIM To investigate the pathogenic effect ofSEB and D-GalN on liver and the protection ofcyclosporin A, the relationship between hepaticapoptosis and necrosis and the possiblemechanism of acute hepatic necrosis.METHODS After staphylococcal enterotoxin B(SEB ) mixed with D--galactosamine (D-GaiN )were injected intraperitoneally into Balb/c miceand those previously treated with cyclosporin A,blood samples were collected and livers wereisolated at 2, 6, 12 and 24 h. Patterns othepatocellular death were studiedmorphologically and biochemically, circulatingcytokines (TNF-a, IFN--y ) and mice mortalitywithin 24h was assessed.RESU’LTS The SEB could induce the typicalapoptotic changes of hepatocytes, the D-GaiNcould induce hepatocytes apoptosis anddegeneration at the same time, and the micehaving received the SEB + D-GaiN injectionsdeveloped apoptosis at 2 and 6 h, but after 12 hhepatocytes were characterized by severein jury, whereas all the examinations in thecyclosporin A treated mice were normal.CONCLUSION Hepatic cell apoptosis might berelated to necrosis, and massive hepatocyteapoptosis is likely the initiating step of acutehepatic necrosis in mice. The effects induced bySEB and D--GaiN on hepatocytes might bemediated by T cells, and could be prevented bycyclosporin A. | Yin, T Tong, SQ Xie, YC Lu, DY | 1999 | World Journal of Gastroenterology1999，5，3： | 2 |
| 2 | Transvaginal sonography and theconservative management of spontaneous abortion 显示文摘 | Haines C J Chung T Leung DY | 1994 | Gyneeol Obstet Invest1994，37，1： | 1 |
| 3 | Efficacy of platinum-based chemotherapy after cranial radiation in patients with brain me- tastasis from non-small cell lung cancer显示文摘 | Kim DY Lee KW Yun T | 2005 | Oncol Rep2005，14，1： | 1 |
| 4 | Functional diversification of the two C-class genes OsMADS3 and OsMADS58 in Oryza sativa 显示文摘 | YAMAGUCHI T LEE DY MIYAO A | 2006 | The Plant Cell2006，18，： | 1 |
| 5 | Pharmacokinetic study of moda-finil in relation to gender and ethnicity in healthy youngchinese volunteers显示文摘 | GUO T ZHAO LS XIA DY | 2010 | J Pharm Pharmaceut Sci2010，13，3： | 1 |
| 6 | Normal range and variation of the zona pellucida-induced acrosome reaction in fertilemen显示文摘 | Liu DY Stewart T Baker HW | | 0，，02： | 1 |
| 7 | Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord 显示文摘 | Steve S Kang DY Mujtaba T | 2002 | Exp Neurol2002，177，： | 1 |
| 8 | CsBi4Te6:A high-performance thermoelectric material for low-temperature applications显示文摘 | Chang DY Hogan T Brazis P | 2000 | Science2000，287，5455： | 1 |
| 9 | Allele and genotype frequencies of CYP3A4,CYP2C19,and CYP2D6 in Han,Uighur,Hui,and Mongolian Chinese populations显示文摘 | Zuo LJ Guo T Xia DY | | 0，，： | 1 |
| 10 | Diffusion-weighted magnetic resonance imaging in differentiation of postobstructive consolidation from central lung carcinoma显示文摘 | Baysal T Mutlu DY Yologlu S | 2009 | Magnetic Resonance Imaging2009，27，10： | 1 |
| 11 | Small cell lung cancer显示文摘 | Sher T Dy GK Adjei AA | 2008 | Mayo Clin Proc2008，83，3： | 1 |
| 12 | Atopic dermatitis显示文摘 | Leuag DY Bieber T | 2003 | Laneet2003，361，9352： | 1 |
| 13 | Diffusion-weighted magnetic resonance imaging in differentiation of postobstruetive consolidation from central lung carcinoma显示文摘 | Baysal T Mutlu DY Yologlu S | 2009 | Magn Reson Imaging2009，27，10： | 1 |
| 14 | Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl-2-picrykhydrazyl radical 显示文摘 | Cho EJ Yokozawa T Rhyu DY | 2003 | Phytomedicine2003，10，67： | 1 |
| 15 | Isolation and localization of type Ⅱb Na/Pi cotransporter in the developing rat lung显示文摘 | Hashimoto M Wang DY Kamo T | 2000 | Am J Pathol2000，157，1： | 1 |
| 16 | Effects intracere- bral microinjection and intraperitoneal injection of fullerene on brain functions differ in rats显示文摘 | Yamada T Jung DY Sawada R | 2008 | J Nanosci Nanotechnol2008，8，8： | 1 |
| 17 | Identification of the gene for vitamin K epoxide reductase显示文摘 | Li T Chang CY Jin DY | 2004 | Nature2004，427，5： | 1 |
| 18 | Immunoglobulin M antibodies present in the acute phase of Kawasaki syndrome lyse cultured vascular endothelial cells stimulated by gamma interferon显示文摘 | Leung DY Collins T Lapierre LA | 1986 | J Clin Invest1986，77，： | 1 |
| 19 | Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1 显示文摘 | Jo DY Rafii S Hamada T | 2000 | J clin Invest2000，105，： | 1 |
| 20 | Immune mechanisms leading to atopic dermatitis显示文摘 | Novak N Bieber T Leung DY | 2003 | J Allergy Clin Immunol2003，112，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员