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| 1 | Diagnosis and treatment of hepatocellular carcinoma: An update显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignancies leading to high mortality rates in the general population; in cirrhotic patients, it is the primary cause of death. The diagnosis is usually delayed in spite of at-risk population screening recommendations, i.e., patients infected with hepatitis B or C virus. Hepatocarcinogenesis hinges on a great number of genetic and molecular abnormalities that lead to tumor angiogenesis and foster their dissemination potential. The diagnosis is mainly based on imaging studies such as computed tomography and magnetic resonance, in which lesions present a characteristic classical pattern of early arterial enhancement followed by contrast medium 'washout' in late venous phase. On occasion, when imaging studies are not conclusive, biopsy of the lesion must be performed to establish the diagnosis. The Barcelona Clinic Liver Cancer staging method is the most frequently used worldwide and recommended by the international guidelines of HCC management. Currently available treatments include tumor resection, liver transplant, sorafenib and locoregional therapies(alcoholization, radiofrequency ablation, chemoembolization). The prognosis of hepatocarcinoma is determined according to the lesion's stage and in cirrhotic patients, on residual liver function. Curative treatments, such as liver transplant, are sought in patients diagnosed in early stages; patients in more advanced stages, were not greatly benefitted by chemotherapy in terms of survival until the advent of target molecules such as sorafenib. | Javier Tejeda-Maldonado Ignacio García-Juárez Jonathan Aguirre-Valadez Adrián González-Aguirre Mario Vilatobá-Chapa Alejandra Armengol-Alonso Francisco Escobar-Penagos Aldo Torre Juan Francisco Sánchez-ávila Diego Luis Carrillo-Pérez | 2015 | World Journal of Hepatology2015，7，3： | 22 |
| 2 | Depression, quality oflife, andglycemic control in individuals with type 2 diabetes 显示文摘 | Lee H J Chapa D Kao CW | 2009 | J Am Acad Nurse Pratt2009，21，4： | 1 |
| 3 | Gender differences in sympathetic nervous system regulation显示文摘 | Hinojosa-Laborde C Chapa I Lange D | 1999 | Clin Exp Pharmacol Physiol1999，26，2： | 1 |
| 4 | Applying petri nets in active database systems显示文摘 | LI XIAOOU MEDINA J M CHAPA S V | 2007 | IEEE Transactions on Systems Man and Cybernetics2007，37，4： | 1 |
| 5 | Effects of interventions on depression in heart failure: A system- atic review 显示文摘 | Woltz PC Chapa DW Friedmann E | 2012 | Heart Lung2012，41，5： | 1 |
| 6 | Depression,quality of life, and glyeemie contrilin individuals with type 2 diabetes显示文摘 | Lee H J Chapa D Kao C W | 2009 | Am Acad Nures Praet2009，21，4： | 1 |
| 7 | A remarkable iodine-catalyzed protection of carbonyl compounds显示文摘 | Banik B K Chapa M Marquez J | 2005 | Tetrahedron Lett2005，46，： | 1 |
| 8 | Modeling of thermal stresses in a graded Cu/W joint 显示文摘 | Chapa J Reimanis I | 2002 | Journal of Nuclear Materials2002，303，： | 1 |
| 9 | Depression, quality of life, and glycemic control in individuals with type 2 dia- betes 显示文摘 | Lee HJ Chapa D Kao CW | 2009 | JAmAcadNursePract2009，21，4： | 1 |
| 10 | Nonlinear prefilter to pre- vent pilot-induced oscillations due to actuator rate limiting 显示文摘 | Liebst B S Chapa M J Leggett D B | 2002 | Journal of Guidance Control and Dynamics2002，25，4： | 1 |
| 11 | Successful treatment of atrophic postoperative and traumatic scarring with carbon dioxide ablative fractional resurfacing: quantitative volumetric scar improvement 显示文摘 | Weiss ET Chapas A Brightman L | 2010 | Arch Dermatol2010，146，2： | 1 |
| 12 | Class specifie antibody responses tonewborn larva antigens during Trichinella spit alis human infection显示文摘 | Mendez LB Martinezy ZR Chapa RR | 2001 | Parasite2001，8，2： | 1 |
| 13 | Influence of Al and Nb on Optimum Ti/N Ratio in Controlling Austenite Grain Growth at Reheating Temperatures显示文摘 | Chapa M Medina S F Lopez V | 2002 | ISIJ International2002，42，11： | 1 |
| 14 | Efficacy of early treatment of facial port wine stains in newborns : a review of 49 cases显示文摘 | CHAPAS A M EICKHORST K GERONEMUS R G | 2007 | Lasers Surg Med2007，39，7： | 1 |
| 15 | Knowledge management in research and development显示文摘 | Armbrencht Jr Ross F M Chapas R B | 2001 | Research Technology Management2001，44，4： | 1 |
| 16 | Depression,quality of life,and glycemic control in individuals with type 2 diabetes显示文摘 | Lee HJ Chapa D Kao CW | 2009 | J Am Acad Nurse Pract2009，21，21： | 1 |
| 17 | Vanilloids induce oral cancer apoptosis independent of TRPV1 显示文摘 | Gonzales CB Kirma NB De La Chapa JJ | 2014 | Oral oncology2014，50，5： | 1 |
| 18 | Determination of critical temperatures Tnr,Ar3,Arl in hot rolling of structural steels with different Ti and N contents 显示文摘 | Vega M I Medina S F Chapa M | 1999 | ISIJ International1999，39，12： | 1 |
| 19 | Modeling of thermal stresses in a graded Cu/W joint显示文摘 | CHAPA J REIMANIS I | 2002 | Journal of Nuclear Materials2002，303，23： | 1 |
| 20 | Physiologic changes in vascular birthmarks during early infancy: mechanisms and clinical implications显示文摘 | Chapas AM Geronemus RG | 2009 | J Am Acad Dermatol2009，61，6： | 1 |
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