|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunogenicity and safety of NVSI-06-07 as a heterologous booster after priming with BBIBP-CorV:a phase 2 trial显示文摘The increased coronavirus disease 2019(COVID-19)breakthrough cases pose the need of booster vaccination.We conducted a randomised,double-blinded,controlled,phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine(BBIBP-CorV)followed by a recombinant protein-based vaccine(NVSI-06-07),using homologous boost with BBIBP-CorV as control.Three groups of healthy adults(600 individuals per group)who had completed two-dose BBIBP-CorV vaccinations 1–3 months,4–6 months and≥6 months earlier,respectively,were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost.Immunogenicity assays showed that in NVSI-06-07 groups,neutralizing antibody geometric mean titers(GMTs)against the prototype SARS-CoV-2 increased by 21.01–63.85 folds on day 28 after vaccination,whereas only 4.20–16.78 folds of increases were observed in control groups.For Omicron variant,the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14,however,a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster.Similar results were obtained for other SARS-CoV-2 variants of concerns(VOCs),including Alpha,Beta and Delta.Both heterologous and homologous boosters have a good safety profile.Local and systemic adverse reactions were absent,mild or moderate in most participants,and the overall safety was quite similar between two booster schemes.Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs,including Omicron. | Nawal Al Kaabi Yun Kai Yang Jing Zhang Ke Xu Yu Liang Yun Kang Ji Guo Su Tian Yang Salah Hussein Mohamed Saif ElDein Shuai Shao Sen Sen Yang Wenwen Lei Xue Jun Gao Zhiwei Jiang Hui Wang Meng Li Hanadi Mekki Mekki Walid Zaher Sally Mahmoud Xue Zhang Chang Qu Dan Ying Liu Jing Zhang Mengjie Yang Islam Eltantawy Peng Xiao Zhao Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zhang Ning Liu Fu Jie Shen Liang Qu Yun Tao Zhang Xiao Ming Yang Guizhen Wu Qi Ming Li | 2022 | Signal Transduction and Targeted Therapy2022，7，7： | 2 |
| 2 | Use of response surface methodology to optimize culture medium for production of lovastatin by Monascus rubber显示文摘 | Chang Yaw-Nan Huang Jen-Chang Lee Chih-Chen et al | 2002 | Enzyme and Microbial Technology2002，30，3： | 1 |
| 3 | Association between blood pressure variability and inflammatory marker in hypertensive patients 显示文摘 | Kim K I Lee J H Chang H J et al | 2008 | Circ J2008，72，2： | 1 |
| 4 | Dexamethasone suppresses apoptosis in a human gastric cancer cell line through modulation of bcl-x gene expression显示文摘 | Chang T C Hung M W Jiang S Y el al | 1997 | FEBS Lett1997，415，1： | 1 |
| 5 | Surgical treatment of severe angular kyphosis with myelopathy: anterior and poste- rior approach with pedicle screw instrumentation 显示文摘 | Song KS Chang BS Yeom JS el al | 2008 | Spine2008，33，11： | 1 |
| 6 | Delayed preconditioning by scvoflurane elicits changes in the mitochondrial proteome in ischemia-repeffused rat hearts 显示文摘 | Xiao YY Chang YT Ran K ct al | 2011 | Anesthesia & Analgesia2011，113，2： | 1 |
| 7 | Pediatric traumatic brain injury:the utility of beta-natriuretie peptide显示文摘 | Chang TP Nager AL | 2010 | J Trauma2010，68，6： | 1 |
| 8 | Continuous intravenous infusion of CGS 26303, an endothelin-coverting enzyme inhibitor, prevents and reverses cerebral vasospasm after experimental subarachnoid hemorrhage 显示文摘 | Kwan AL Lin CL Chang CZ | 2001 | Neurosur-gery2001，49，2： | 1 |
| 9 | Margin clearance and outcome in resected pancreatic cancer显示文摘 | Chang DK Johns AL Merrett ND | 2009 | J Clin Oncol2009，27，17： | 1 |
| 10 | Alpha - phenyl - N - tert - butylni-trone attenuates hyperoxia - induced lung injury by down - modulatinginflammation in neonatal rats 显示文摘 | Chang YS Kim YJ Yoo HS e( al | 2009 | Exp Lung Res2009，35，3： | 1 |
| 11 | A routine model for studying diffusely injected human fat 显示文摘 | Thanik VD Chang CC Lerman OZ ct al | 2009 | Plast Reconstr Surg2009，124，1： | 1 |
| 12 | Mutation analysis of Crouzon syndrome in Taiwanese patients 显示文摘 | Chang CP Wan L Tsai CH et al | 2006 | J Clin Lab Anal2006，20，： | 1 |
| 13 | Awareness of memory impair-ment increases the adherence to immunosuppressants in kidney trans-plant recipients 显示文摘 | Cheng CY Lin BYJ Chang KH e? al | 2012 | Transplant Proceed Elsevi2012，44，3： | 1 |
| 14 | Mechanisms of X-chromosome inactivation显示文摘 | Tucker T Tboregcod NP at al | 2006 | Front Biosc2006，11，： | 1 |
| 15 | 15-1Apoxygenastel interleukin-4 mediates apoptosis in oral cavily cancer cells 显示文摘 | Kim JH Chang JH Yoon JH el al | 2006 | Oral Oncol2006，42，8： | 1 |
| 16 | Association of cortactin and fascin-1expression in gastric adenocarcinoma: correlation with clinicopathologicalparameters显示文摘 | Tsai WC Jin JS Chang WK ef al | 2007 | J Histochem Cytochem2007，55，9： | 1 |
| 17 | Bone man'ow-derived mesenehymal stem cells differentiate to hepatic myofibroblasts by transfi~rming growth faetor-~l via sphingosine kinase/sphingosine l-phosphate ( SI P)/S1 P receptor axis显示文摘 | Yang L Chang N Liu X el al | 2012 | Am J Patho]2012，181，1： | 1 |
| 18 | Dietary administration of the probiotic, Lactobacil lus plantarum, enhanced the growth, innate immune responses, and disease resistance of the grouper Epi- nephelus coioides显示文摘 | Son Vo Minh Chang Chin-Chyuan Wu Mi Chen et al | 2009 | Fish : Shellfish Immunology2009，26，5： | 1 |
| 19 | Genetic dele-tion of IL - 17A reduces cigarette smoke - induced inflammationand alveolar type II cell apoptosis显示文摘 | CHANG Y AL ALWAN L AUDUSSEAU S | | Am J Physiol Lung Cell0，，： | 1 |
| 20 | Tribological properties of epoxy nanoeomposites(I): Enhancement of the wear resistance by nano-TiO2 particles显示文摘 | Chang Lin Zhang Zuo Breidt C er al | 2005 | Wear2005，258，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员