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| 1 | Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation显示文摘Allogeneic hematopoietic stem cell transplantation(alloHSCT)is a life-saving procedure used for the treatment of selected hematological malignancies,inborn errors of metabolism,and bone marrow failures.The role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against infection.However,recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered functions.Accordingly,neutrophils are emerging as highly versatile cells that are able to acquire different,often opposite,functional capacities depending on the microenvironment and their differentiation status.Herein,we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT,from the hematopoietic stem cell(HSC)mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion.We also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versushost disease(GVHD)prophylaxis.Finally,the potential involvement of neutrophils in alloHSCT-related complications,such as transplant-associated thrombotic microangiopathy(TA-TMA),acute and chronic GVHD,and cytomegalovirus(CMV)reactivation,is also discussed.Based on the data reviewed herein,the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial role.However,much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT. | Cristina Tecchio Marco Antonio Cassatella | 2021 | Cellular & Molecular Immunology2021，18，4： | 3 |
| 2 | Activation of the NF-kappa B pathway by inflammatory stimuli in the human neutrophils 显示文摘 | Bald A Cassatella MA | 1997 | Blood1997，89，9： | 1 |
| 3 | Tumor - associated macrophages as major source of APRIL in gastric MALT lymphoma显示文摘 | MUNARIF LONARDI S CASSATELLA M A | 2011 | Blood2011，117，24： | 1 |
| 4 | The defensive alliance between neutrophils and NK cells as a novel ann of innate immunity显示文摘 | Costantini C Cassatella MA | 2011 | J Leukoy Biol2011，89，2： | 1 |
| 5 | Soluble TNFlike cytokine (TL1 A) production by immune complexes stimulated monocytes in rheumatoid arthritis显示文摘 | Cassatella MA Pereira-da-Silva G Tinazzi I | 2007 | J Immunol2007，178，11： | 1 |
| 6 | Neu-trophils in the activation and regulation of innate andadaptive immunity显示文摘 | Mantovani A Cassatella MA Costantini C | 2011 | Nat Rev Immunol2011，11，8： | 1 |
| 7 | Activation of microglia cells by beta-amyloid protein and interferon-gamma 显示文摘 | MEDA L CASSATELLA MA SZENDREI GI | 1995 | Nature1995，374，6523： | 1 |
| 8 | Interleukin 10 (IL- 10) upregulates IL-1 receptor antagonist production from lipopolysaccharide stimulated human polymorphonuclear leukocytes by delaying mRNA degradation 显示文摘 | Cassatella MA Meda L Gasperini S | 1994 | J Exp Med1994，179，： | 1 |
| 9 | Activation of transcription factor NFkappa B by phagocytic stimuli in human neutrophils显示文摘 | McDonald PP Cassatella MA | 1997 | FEBS Lett1997，412，3： | 1 |
| 10 | Involvement ofsuppressor of eytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaeeharide-induede maerophage activation显示文摘 | Berlato C Cassatella MA Kinjyo I | 2002 | J Immunol2002，168，12： | 1 |
| 11 | Soluble TNF-like eytokine (TL1A) production by immune complexes stimulated monoeytes in rheumatoid arthritis显示文摘 | Marco A Cassatella GP Ilaria Tinazzi | 2007 | J Immunol2007，178，： | 1 |
| 12 | Regulation ofB-cell-activating factor (BAFF)/B lymphocyte stimulator (BLyS) expression in human neutrophils 显示文摘 | SCAPINI P BAZZONI F CASSATELLA M A | 2008 | Immunol Lett2008，116，1： | 1 |
| 13 | Activation of microglial cells by beta-amyloid protein and interferon-gamma 显示文摘 | Meda L Cassatella MA Szendrei GI Otvos L Jr Baron P Villalba M | 1995 | Nature1995，374，6523： | 1 |
| 14 | Changes in circulating tumor cell detection in patients with localized breast cancer before and after surgery显示文摘 | Sandri MT Zorzino L Cassatella MC | 2010 | Ann Surg Oncol2010，17，6： | 1 |
| 15 | Activation of the NF-gB pathway by in flammatory stimuli in human neutrophils 显示文摘 | MCDONALD P P BALD A CASSATELLA M A | 1997 | Blood1997，89，： | 1 |
| 16 | Phagocytosing neutrophils produce and release high amounts of the neutrophil-acti vating peptide 1/IL-8显示文摘 | Bazzoni F Cassatella MA Rossi F | 1991 | J Exp Med1991，173，3： | 1 |
| 17 | Activation of microglial cells by beta-amyloid protein and interferongamma显示文摘 | Meda L Cassatella MA Szendrei GI | 1995 | Nature1995，374，6523： | 1 |
| 18 | Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation显示文摘 | Berlato C Cassatella MA Kinjyo I | 2002 | J Immunol2002，168，12： | 1 |
| 19 | Interleukin-12 production by human polymorphonuclear leukocytes显示文摘 | Cassatella MA Meda L Gasperini S | 1995 | Eur J Immunol1995，25，1： | 1 |
| 20 | Activation of the NF-κB pathway by inflammatory stimuli in human neutrophils 显示文摘 | McDonald PP Bald A Cassatella MA | 1997 | Blood1997，89，9： | 1 |
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