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| 1 | Pediatric gastrointestinal bleeding: Perspectives from the Italian Society of Pediatric Gastroenterology显示文摘There are many causes of gastrointestinal bleeding(GIB) in children, and this condition is not rare, having a reported incidence of 6.4%. Causes vary with age, but show considerable overlap; moreover, while many of the causes in the pediatric population are similar to those in adults, some lesions are unique to children. The diagnostic approach for pediatric GIB includes definition of the etiology, localization of the bleeding site and determination of the severity of bleeding; timely and accurate diagnosis is necessary to reduce morbidity and mortality. To assist medical care providers in the evaluation and management of children with GIB, the 'Gastro-Ped Bleed Team' of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition(SIGENP) carried out a systematic search on MEDLINE via Pub Med(http://gffzz16a62c593b5540cehbpb5uuon905066p5.ffgz.tsg.suse.edu.cn/pubmed/) to identify all articles published in English from January 1990 to 2016; the following key words were used to conduct the electronic search: 'upper GIB' and 'pediatric' [all fields]; 'lower GIB' and 'pediatric' [all fields]; 'obscure GIB' and 'pediatric' [all fields]; 'GIB' and 'endoscopy' [all fields]; 'GIB' and 'therapy' [all fields]. The identified publications included articles describing randomized controlled trials, reviews, case reports, cohort studies, casecontrol studies and observational studies. References from the pertinent articles were also reviewed. This paper expresses a position statement of SIGENP that can have an immediate impact on clinical practice and for which sufficient evidence is not available in literature. The experts participating in this effort were selected according to their expertise and professional qualifications. | Claudio Romano Salvatore Oliva Stefano Martellossi Erasmo Miele Serena Arrigo Maria Giovanna Graziani Sabrina Cardile Federica Gaiani Gian Luigi de'Angelis Filippo Torroni | 2017 | World Journal of Gastroenterology2017，23，8： | 12 |
| 2 | Current issues in pediatric inflammatory bowel diseaseassociated arthropathies显示文摘Joint involvement is the most common extraintestinal manifestation in children with inflammatory bowel disease(IBD)and may involve 16%-33%of patients at diagnosis or during follow-up.It is possible to distinguish asymmetrical,transitory and migrating arthritis(pauciarticular and polyarticular)and spondyloarthropathy(SpA).Clinical manifestations can be variable,and peripheral arthritis often occurs before gastrointestinal symptoms develop.The inflammatory intestinal pattern is variable,ranging from sub-clinical inflammation conditions,classified as indeterminate colitis and nodular lymphoid hyperplasia of the ileum,to Crohn’s disease or ulcerative colitis.Unlike the axial form,there is an association between gut inflammation and evolution of recurrent peripheral articular disease that coincides with a flare-up of intestinal disease.This finding seems to confirm a key role of intestinal inflammation in the pathogenesis of SpA.An association between genetic background and human leukocyte antigen-B27 status is less common in pediatric than n adult populations.Seronegative sacroiliitis and SpA are the most frequent forms of arthropathy in children with IBD.In pediatric patients,a correct therapeutic approach relies on the use of nonsteroidal antiinflammatory drugs,local steroid injections,physiotherapy and anti-tumor necrosis factor therapy(infliximab).Early diagnosis of these manifestations reduces the risk of progression and complications,and as well as increasing the efficacy of the therapy. | Sabrina Cardile Claudio Romano | 2014 | World Journal of Gastroenterology2014，20，1： | 9 |
| 3 | Italian survey on non-steroidal anti-inflammatory drugsand gastrointestinal bleeding in children显示文摘AIM: To investigate gastrointestinal complications associated with non-steroidal anti-inflammatory drug(NSAIDs) use in children.METHODS: A retrospective, multicenter study was conducted between January 2005 and January 2013, with the participation of 8 Italian pediatric gastroenterology centers. We collected all the cases of patients who refer to emergency room for suspected gastrointestinal bleeding following NSAIDs consumption, and underwent endoscopic evaluation. Previous medical history, associated risk factors, symptoms and signs at presentation, diagnostic procedures, severity of bleeding and management of gastrointestinal bleeding were collected. In addition, data regarding type of drug used, indication, dose, duration of treatment and prescriber(physician or selfmedication) were examined. RESULTS: Fifty-one patients, including 34 males, were enrolled(median age: 7.8 years). Ibuprofen was the most used NSAID [35/51 patients(68.6%)]. Pain was the most frequent indication for NSAIDs use [29/51 patients(56.9%)]. Seven patients had positive family history of Helicobacter pylori(H. pylori) infection or peptic ulcer, and 12 had associated comorbidities. Twenty-four(47%) out of 51 patients used medication inappropriately. Hematemesis was the most frequent symptom(33.3%). Upper gastrointestinal endoscopy revealed gastric lesions in 32/51(62%) patients, duodenal lesions in 17(33%) and esophageal lesions in 8(15%). In 10/51(19.6%) patients, a diagnosis of H. pylori gastritis was made. Forty-eight(94%) patients underwent medical therapy, with spontaneous bleeding resolution, while in 3/51(6%) patients, an endoscopic hemostasis was needed.CONCLUSION: The data collected in this study confirms that adverse events with the involvement of the gastrointestinal tract secondary to NSAID use are also common in | Sabrina Cardile Massimo Martinelli Arrigo Barabino Paolo Gandullia Salvatore Oliva Giovanni Di Nardo Luigi Dall'Oglio Francesca Rea Gian Luigi de'Angelis Barbara Bizzarri Graziella Guariso Enzo Masci Annamaria Staiano Erasmo Miele Claudio Romano | 2016 | World Journal of Gastroenterology2016，22，5： | 7 |
| 4 | Gastric volvulus, bor- chardt's triad, and endoscopy: a rare twist显示文摘 | CARDILE A P HEPPNER D S | 2011 | Hawaii Med J2011，70，4： | 1 |
| 5 | Adaptive responses to the stress induced by hyperthermia or hydrogen peroxide in human fibroblasts显示文摘 | Grasso S Scifo C Cardile V | 2003 | Exp Biol Med2003，228，5： | 1 |
| 6 | TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents 显示文摘 | Valerio A Cardile A Cozzi V | 2006 | J Clin Invest2006，116，10： | 1 |
| 7 | Glutamine synthetase activity and HSP70 levels in cultured rat astrocytes: effect of 1-octadecyl-2methylrac-glycero-3phosphocholine显示文摘 | Renis M Cardile V Russo A | 1998 | Brain Res1998，783，： | 1 |
| 8 | Psoralea glandulosa as a potential source of anticancer agents for melanoma treatment 显示文摘 | Madrid A Cardile V Gonzalez C | 2015 | Int J Mol Sci2015，16，4： | 1 |
| 9 | Involvement of HSP 70 in resveratrol-induced apoptosis of human prostate cancer显示文摘 | Cardile V Scifo C Russo A | 2003 | Anticancer Res2003，23，6： | 1 |
| 10 | Branched-chain amino acid supplementation promotessurvival and supports cardiac and skeletal muscle mi-tochondrial biogenesis in middle-aged mice 显示文摘 | D1 ANTONA G RAGNI M CARDILE A | 2010 | CellMetabolism2010，12，4： | 1 |
| 11 | ^197Au MOssbauer study of Au2S and gold adsorbed onto As2S3 and Sb2S3 substrates显示文摘 | Cardile C M Cashion J D D McGrath A C | 1993 | Geochimiea et Cosmochimica Acta1993，57，： | 1 |
| 12 | Chemoenzymatic synthesis and cell-growth inhibition activity of resveratrol analogues显示文摘 | Cardile V Lombardo L Spatafora C | 2005 | Bioorg Chem2005，33，1： | 1 |
| 13 | Protective effect of Capparis spinosa on chondrocyles 显示文摘 | Panico A M Cardile V | 2005 | Life Sci2005，，6： | 1 |
| 14 | Single intraoperative application verus postoperative mitomycin C eye drops in pterygium surgery显示文摘 | Cardill JA Alves MR Ambrosio LE | 1995 | Ophthalmology1995，102，： | 1 |
| 15 | TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents 显示文摘 | Valerio A Cardile A Cozzi V | 2006 | J Clin Invest2006，116，10： | 1 |
| 16 | Protective effect of Capparis spinosa on chondrocytes 显示文摘 | Panico AM Cardile V Garufi F | 2005 | Life Sci2005，77，20： | 1 |
| 17 | Glutamine synthetase activity and HSP70 levels in cultured rat astrocytes:effect of 1-octadecyl-2methyl-racglycero-3phosphocholine显示文摘 | Renis M Cardile V Russo A | 1998 | Brain Res1998，783，： | 1 |
| 18 | Glutamine synthetase activi- ty and HSP70 levels in cultured rat astrocytes: effect of 1-octadecyl- 2-methyl-rac-glycero-3-phosphocholine 显示文摘 | Renis M Cardile V Russo A | 1998 | Brain Res1998，783，67： | 1 |
| 19 | Protective effect of Capparis spinosa on chondrocytes显示文摘 | PANICO A M CARDILE V GARUFI F | 2005 | Life Sciences2005，77，： | 1 |
| 20 | Protective effect of Capparis spinosa on chon-drocytes显示文摘 | PANICO A M CARDILE V | 2005 | Life Sci2005，，6： | 1 |
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