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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Terahertz Semiconductor Quantum Well Devices显示文摘For eventually providing terahertz science with compact and convenient devices,terahertz (1~10THz) quantum-well photodetectors and quantum-cascade lasers are investigated.The design and projected detector performance are presented together with experimental results for several test devices,all working at photon energies below and around optical phonons.Background limited infrared performance (BLIP) operations are observed for all samples (three in total),designed for different wavelengths.BLIP temperatures of 17,13,and 12K are achieved for peak detection frequencies of 9.7THz(31μm),5.4THz(56μm),and 3.2THz(93μm),respectively.A set of THz quantum-cascade lasers with identical device parameters except for doping concentration is studied.The δ-doping density for each period varies from 3.2×1010 to 4.8×1010cm-2.We observe that the lasing threshold current density increases monotonically with doping concentration.Moreover,the measurements for devices with different cavity lengths provide evidence that the free carrier absorption causes the waveguide loss also to increase monotonically.Interestingly the observed maximum lasing temperature is best at a doping density of 3.6×1010cm-2. | Liu H C Luo H Ban D Waichter M Song C Y Wasilewski Z R Buchanan M Aers G C SpringThorpe A J Cao J C Feng S L Williams B S Hu Q | 2006 | Journal of Semiconductors2006，27，4： | 2 |
| 3 | Transcatheter device closure of atrial septal defects in patients older than 60 years of age:immediate and follow-up results显示文摘 | Elshershari H Cao Q L Hijazi Z M | 2008 | J Invasive Cardiol2008，20，4： | 1 |
| 4 | A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy显示文摘 | Lee H Cao L Mostoslavsky R | 2008 | Proc Natl Acad Sci USA2008，105，： | 1 |
| 5 | Application of support vector machines in financial time series forecasting 显示文摘 | TAY F E H CAO L J | 2001 | Omega2001，29，4： | 1 |
| 6 | Mural granulosa cellgene expression associated with oocye developmental compe-tence显示文摘 | Jiang J Y Xiong H L Cao M J | 2010 | Ovarian Res2010，3，1： | 1 |
| 7 | Spinal cord repair in adult paralegic rats: Partial restoration of hind limb function 显示文摘 | Cheng H Cao Y and Olson L | 1996 | Science1996，273，： | 1 |
| 8 | Modified support vector machines in financial time series forecasting显示文摘 | TAY F E H CAO L J | 2002 | Neurocomputing2002，48，： | 1 |
| 9 | Spinal cord repair in adult paraplegic rats:Partial restoration of hind limb function显示文摘 | Cheng H Cao Y Olson L | 1996 | Science1996，273，： | 1 |
| 10 | Support vector machine with adaptive parameters in financial time series forecasting显示文摘 | Cao L J Tay Francis E H | 2003 | IEEE Trans- actions on Neural Networks2003，6，14： | 1 |
| 11 | Coexistence of high levels of apoptotic signaling and inhibitor of apoptosis proteins in human tumor cells:implication for cancer specific therapy 显示文摘 | Yang L Cao Z Yan H | 2003 | Cancer Res2003，63，： | 1 |
| 12 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 13 | Synthesis and Photolumi- nescence of Silica Nanowires Grown on Si Substrate显示文摘 | Cao L Z Song H Jiang H | 2011 | J Inorg Organomet Polym2011，21，4： | 1 |
| 14 | Dynamic response of pavements on poroelastic half-space soil medium to a moving traffic load显示文摘 | Cai Y Q Cao Z G Sun H L | | 0，，： | 1 |
| 15 | Efficacy of hyperbaric oxygen treatment for depression in the convalescent stage following cerebral hemorrhage显示文摘 | Cao H Ju K Zhong L | 2013 | Exp Ther Med2013，5，6： | 1 |
| 16 | Study of the potential electrochemical noise during corrosion process of aluminum alloys 2024, 7075 and pure aluminum显示文摘 | CHENGY L ZHANGZ CAO F H | 2003 | Materials and Corrosion2003，54，： | 1 |
| 17 | Synthesis of an ultrafine grained TiAl based alloy by subzero temperature milling and HIP: Its microstructure and mechanical properties 显示文摘 | YU H B ZHANG D L CHEN Y Y CAO P GABBITAS B | 2009 | Journal of Alloys and Compounds2009，474，12： | 1 |
| 18 | Acaricidal activities of extracts of Stellera chamaejasme against Tetranychus viennensis (Acari: Tetraanychidae) 显示文摘 | Shi G L Liu S Q Cao H | 2004 | JOURNAL OF ECONOMIC ENTOMOLOGY2004，97，6： | 1 |
| 19 | The effect of VEGF on the temporal spatial change of (-Tubulin and cortical granule of ovine oocytes matured in vitro显示文摘 | Cao X Zhou P Luo H L | 2009 | Anita Reprod Sci2009，，23： | 1 |
| 20 | Natriuretic peptides and right atrial fibrosis in patients with paroxysml versus persistent atrial fibrillation 显示文摘 | Cao H Xue L Wu Y | 2010 | Pep- tides2010，31，8： | 1 |
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