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| 1 | Clinical characteristics and prognostic impact of atrial fibrillation in patients with chronic heart failure显示文摘AIM To assess the prevalence, clinical characteristics and independent prognostic impact of atrial fibrillation(AF) in chronic heart failure(CHF) patients, and the potential protective effect of disease-modifying medications, particularly beta-blockers(BB). METHODS We retrospectively reviewed the charts of patients referred to our center since January 2004, and collected all clinical information available at their first visit. We assessed mortality to the end of June 2015. We compared patients with and without AF, and assessed the association between AF and all-cause mortality by multivariate Cox regression and Kaplan-Meyer analysis, particularly accounting for ongoing treatment with BB.RESULTS A total of 903 patients were evaluated(mean age 68 ± 12 years, 73% male). Prevalence of AF was 19%, ranging from 10% to 28% in patients ≤ 60 and ≥ 77 years, respectively. Besides the older age, patients with AF had more symptoms(New York Heart Association II-III 60% vs 44%), lower prevalence of dyslipidemia(23% vs 37%), coronary artery disease(28% vs 52%) and left bundle branch block(9% vs 16%). On the contrary, they more frequently presented with an idiopathic etiology(50% vs 24%), a history of valve surgery(13% vs 4%) and received overall more devices implantation(31% vs 21%). The use of disease-modifying medications(i.e., BB and ACE inhibitors/angiotensin receptor blockers) was lower in patients with AF(72% vs 80% and 71% vs 79%, respectively), who on the contrary were more frequently treated with symptomatic and antiarrhythmic drugs including diuretics(87% vs 69%) and digoxin(51% vs 11%). At a mean follow-up of about 5 years, all-cause mortality was significantly higher in patients with AF as compared to those in sinus rhythm(SR)(45% vs 34%, P value < 0.05 for all previous comparisons). However, in a multivariate analysis including the main significant predictors of allcause mortality, the univariate relationship between AF and death(HR = 1.49, 95%CI: 1.15-1.92) became not statistically significant(HR = 0.98, 95%CI: 0.73-1.32). Nonetheless, patients with AF not receiving BB treatment were found to have the worst prognosis, followed by patients with SR not receiving BB therapy and patients with AF receiving BB therapy, who both had similarly worse survival when compared to patients with SR receiving BB therapy.CONCLUSION AF was highly prevalent and associated with older age, worse clinical presentation and underutilization of disease-modifying medications such as BB in a population of elderly patients with CHF. AF had no independent impact on mortality, but the underutilization of BB in this group of patients was associated to a worse long-term prognosis. | Lorenzo Gigli Pietro Ameri Gianmarco Secco Gabriele De Blasi Roberta Miceli Alessandra Lorenzoni Francesco Torre Francesco Chiarella Claudio Brunelli Marco Canepa | 2016 | World Journal of Cardiology2016，8，11： | 4 |
| 2 | Designing interfaces in energy materials applications with firstprinciples calculations显示文摘Materials for energy-related applications,which are crucial for a sustainable energy economy,rely on combining materials that form complex heterogenous interfaces.Simultaneously,progress in computational materials science in describing complex interfaces is critical for improving the understanding and performance of energy materials.Hence,we present an in-depth review of the physical quantities regulating interfaces in batteries,photovoltaics,and photocatalysts,that are accessible from modern electronic structure methods,with a focus on density functional theory calculations.For each energy application,we highlight unique approaches that have been developed to calculate interfacial properties and explore the possibility of applying some of these approaches across disciplines,leading to a unified overview of interface design.Finally,we identify a set of challenges for further improving the theoretical description of interfaces in energy devices. | Keith T.Butler Gopalakrishnan Sai Gautam Pieremanuele Canepa | 2019 | npj Computational Materials2019，，1： | 3 |
| 3 | Correlation between thoracic aorta 18F-natrium fluoride uptake and cardiovascular risk显示文摘AIM: To investigating the relationship between thoracic and cardiac 18F-Natrium-Fluoride(18F-Na F) uptake,as a marker of ongoing calcification and cardiovascular risk factors.METHODS: Seventy-eight patients(44 females,mean age 63,range 44-83) underwent whole body 18F-Na F positron emission tomography/computed tomography. Cardiovascular risk(CVR) was used to divide these patients in three categories: Low(LR),medium(MR) and high risk(HR). 18F-Na F uptake was measured by manually drawing volumes of interest on the ascendingaorta,on the aortic arch,on the descending aorta and on the myocardium; average standardized uptake value was normalized for blood-pool,to obtain target-tobackground ratio(TBR). Values from the three aortic segments were then averaged to obtain an index of the whole thoracic aorta.RESULTS: A significant difference in whole thoracic aorta TBR was detected between HR and LR(1.84 ± 0.76 vs 1.07 ± 0.3,P < 0.001),but also between MR and HR-LR(1.4 ± 0.4,P < 0.02 and P < 0.01,respectively). Significance of this TBR stratification strongly varied among thoracic aorta subsegments and the lowest P values were reached in the descending aorta(P < 0.01). Myocardial uptake provided an effective CVR classes stratification(P < 0.001).Correlation between TBR and CVR was appreciable when the whole thoracic aorta was considered(R = 0.67),but it peaked when correlating the descending thoracic segment(R = 0.75),in comparison with the aortic arch and the ascending segment(R = 0.55 and 0.53,respectively). CONCLUSION: Fluoride uptake within the thoracic aorta wall effectively depicts patients' risk class and correlates with cardiovascular risk. Descending aorta is the most effective in CVR determination. | Francesco Fiz Silvia Morbelli Matteo Bauckneht Arnoldo Piccardo Giulia Ferrarazzo Alberto Nieri Nathan Artom Manlio Cabria Cecilia Marini Marco Canepa Gianmario Sambuceti | 2016 | World Journal of Radiology2016，8，1： | 2 |
| 4 | Analysis of Tonal Noise Generating Mechanisms in Low-Speed Axial-Flow Fans显示文摘The present paper reports a comparison of experimental SPL spectral data related to the tonal noise generated by axial-flow fans.A nine blade rotor has been operated at free discharge conditions and in four geometrical configurations in which different kinds of tonal noise generating mechanisms are present:large-scale inlet turbulent structures,tip-gap flow,turbulent wakes,and rotor-stator interaction.The measurements have been taken in a hemi-anechoic chamber at constant rotational speed and,in order to vary the acoustic source strength,during low angular acceleration,linear speed ramps.In order to avoid erroneous quantitative evaluations if the acoustic propagation effects are not considered,the acoustic response functions of the different test configurations have been computed by means of the spectral decomposition method.Then,the properties of the tonal noise generating mechanisms have been studied.To this aim,the constant-Strouhal number SPL,obtained by means of measurements taken during the speed ramps,have been compared with the propagation function.Finally,the analysis of the phase of the acoustic pressure has allowed to distinguish between random and deterministic tonal noise generating mechanisms and to collect information about the presence of important propagation effects. | Edward Canepa Andrea Cattanei Fabio Mazzocut Zecchin | 2016 | Journal of Thermal Science2016，25，4： | 2 |
| 5 | Suggestive evidences for microanatomical relationship between mast ceils and nerve in the tongue of the toad Bufo marinus demonstrated by means of high resolution light microscopy 显示文摘 | Gonzalez Elorriaga M A Canepa G | 2002 | Acta Cient Venez2002，53，4： | 1 |
| 6 | Ti-mcm-41 as catalyst for α-pinene oxidation : study of the effect of Ti content and H2 O2 addition on activity and selectivity 显示文摘 | Casuscelli S G Eimer G A Canepa A | 2008 | Catal Today2008，，： | 1 |
| 7 | Inhibitory effect of cyclic terpenes (limonene, menthol, menthone and thymol) on Fusari- urn verticillioides MRC 826 growth and fumonisin B1 biosynthesis 显示文摘 | DAMBOLENA J S LOPEZ A G CANEPA M C | 2008 | Toxicon2008，51，1： | 1 |
| 8 | INK4 proteins,a family of mammalian CDK inhibitors with novel biological functions显示文摘 | Canepa ET Scassa ME Ceruti JM | 2007 | IMBMB Life2007，59，7： | 1 |
| 9 | Sequential outbreaks of mul- tidrug - resistant Acinetobacter baumannii in intensive care units of a tertiary referral hospital in Italy: combined molecular approach for epidemiological investigation显示文摘 | Ansaldi F Canepa P Bassetti M | 2011 | J Hosp Infect2011，79，2： | 1 |
| 10 | Financial constraints to inno- vation in the UK: evidence from CIS2 and CIS3显示文摘 | CANEPA A STONEMAN P | 2008 | Oxford Economic Papers2008，60，4： | 1 |
| 11 | Serotonergic antidepressants and linezolid:a retrospective chart review and presentation of cases显示文摘 | Lorenz RA Vandenberg AM Canepa EA | 2008 | Int J Psychiatry Med2008，38，： | 1 |
| 12 | Effects of cyclodextrins,humic substances, and rhamnolipids on the washingof a historically contaminated soil and on the aerobic bioremediation of the resulting effluents 显示文摘 | BERSELLI S MILONE G CANEPA P | 2004 | Biotechnology and Bioengineering2004，88，1： | 1 |
| 13 | Current periop erative management of radical cysteetomy with intestinal urinary reconstruction for muscle invasive bladder cancer and reduction of the incidence of postoperative ileus显示文摘 | Maffezzini M Campodonico F Canepa G | 2008 | Surg Oneol2008，17，1： | 1 |
| 14 | Mechanism of acid-catalyzed epoxidation of alkenes with peroxy acids显示文摘 | BACH R D CANEPA C WINTER J E | 1997 | Org Chem1997，62，15： | 1 |
| 15 | A Convenient One-pot Synthesis of 1-aryl-substituted 2H-iso- quinolin-3-ones显示文摘 | MENDEZ L J CANEPA A S GONZALEZ M G | 2011 | Tetrahedron Lett2011，11，： | 1 |
| 16 | Stabilizing token schemes for population protocols 显示文摘 | CANEPA D POTOP-BUTUCARU M | 2008 | Compu- ting Research Repository2008，806，3471： | 1 |
| 17 | Current perioperative management of radical cystectomy with intestinal u r inar y reconstruction for muscle-invasive bladder cancer and reduction of the incidence of postoperative ileus显示文摘 | Maffezzini M Campodonico F Canepa G | 2008 | Surg Oncol2008，17，10： | 1 |
| 18 | A New Algorithm for Automatic Processing of Bathymetric Data显示文摘 | CANEPA G BERGEM O PACE N G | 2003 | IEEE Journal of Oceanic Engineering2003，28，1： | 1 |
| 19 | Transmission electron microscopy of the induced damage by argon implantation in (111) HgCdTe at room temperature 显示文摘 | Myriam H Aguirre Horacio R Canepa Noemi E Walsoede Reca | 2002 | Journal of Applied Physics2002，92，10： | 1 |
| 20 | Ti-MCM-41 as catalyst for a-pinene oxidation,Study of the effect of Ti content and H_2O_2 addition on activity and selectivity显示文摘 | Casuscelli S G Elmer G A Canepa A | 2008 | Catalysis Today2008，133，： | 1 |
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