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| 1 | Using old liver grafts for liver transplantation: Where are the limits?显示文摘The scarcity of ideal liver grafts for orthotopic liver transplantation(OLT) has led transplant teams to investigate other sources of grafts in order to augment the donor liver pool. One way to get more liver grafts is to use marginal donors, a not well-defined group which includes mainly donors > 60 years, donors with hypernatremia or macrosteatosis > 30%, donors with hepatitis C virus or hepatitis B virus positive serologies, cold ischemia time > 12 h, non-heart-beating donors, and grafts from split-livers or living-related donations. Perhaps the most practical and frequent measure to increase the liver pool, and thus to reduce waiting list mortality, is to use older livers. In the past years the results of OLT with old livers have improved, mainly due to better selection and maintenance of donors, improvements in surgical techniques in donors and recipients, and intra- and post-OLT management. At the present time, sexagenarian livers are generally accepted, but there still exists some controversy regarding the use of septuagenarian and octogenarian liver grafts. The aim of this paper is to briefly review the aging process of the liver and reported experiences using old livers for OLT. Fundamentally, the series of septuagenarian and octogenarian livers will be addressed to see if there is a limit to using these aged grafts. | Carlos Jiménez-Romero Oscar Caso Maestro Félix Cambra Molero Iago Justo Alonso Cristina Alegre Torrado Alejandro Manrique Municio Jorge Calvo Pulido Carmelo Loinaz Segurola Enrique Moreno González | 2014 | World Journal of Gastroenterology2014，20，31： | 11 |
| 2 | Liver fat deposition and mitochondrial dysfunction in morbid obesity:An approach combining metabolomics with liver imaging and histology显示文摘AIM: To explore the usefulness of magnetic resonance imaging(MRI) and spectroscopy(MRS) for assessment of non-alcoholic fat liver disease(NAFLD) as compared with liver histological and metabolomics findings. METHODS: Patients undergoing bariatric surgery following procedures involved in laparoscopic sleeve gastrectomy were recruited as a model of obesityinduced NAFLD in an observational, prospective, singlesite, cross-sectional study with a pre-set duration of 1 year. Relevant data were obtained prospectively and surrogates for inflammation, oxidative stress and lipid and glucose metabolism were obtained through standard laboratory measurements. To provide reliable data from MRI and MRS, novel procedures were designed to limit sampling variability and other sources of error using a 1.5T Signa HDx scanner and protocols acquired from the 3D or 2D Fat SAT FIESTA prescription manager. We used our previously described 1H NMRbased metabolomics assays. Data were obtained immediately before surgery and after a 12-mo period including histology of the liver and measurement of metabolites. Values from 1H NMR spectra obtained after surgery were omitted due to technical limitations.RESULTS: MRI data showed excellent correlation with the concentration of liver triglycerides, other hepatic lipid components and the histological assessment, w h i c h e xc l u d e d t h e p r e s e n c e o f n o n-a l c o h o l i c steatohepatitis(NASH). MRI was sufficient to follow up NAFLD in obese patients undergoing bariatric surgery and data suggest usefulness in other clinical situations. The information provided by MRS replicated that obtained by MRI using the-CH3 peak(0.9 ppm), the-CH2- peak(1.3 ppm, mostly triglyceride) and the-CH=CH- peak(2.2 ppm). No patient depicted NASH. After surgery all patients significantly decreased their body weight and steatosis was virtually absent even in patients with previous severe disease. Improvement was also observed in the serum concentrations of selected variables. The most relevant findings using metabolomics indicate increased levels of triglyceride and monounsaturated fatty acids in severe steatosis but those results were accompanied by a significant depletion of diglycerides, polyunsaturated fatty acids, glucose-6-phosphate and the ATP/AMP ratio. Combined data indicated the coordinated action on mitochondrial fat oxidation and glucose transport activity and may support the consideration of NAFLD as a likely mitochondrial disease. This concept may helpto explain the dissociation between excess lipid storage in adipose tissue and NAFLD and may direct the search for plasma biomarkers and novel therapeutic strategies. A limitation of our study is that data were obtained in a relatively low number of patients.CONCLUSION: MRI is sufficient to stage NAFLD in obese patients and to assess the improvement after bariatric surgery. Other data were superfluous for this purpose. | Nahum Calvo Raúl Beltrán-Debón Esther Rodríguez-Gallego Anna Hernández-Aguilera Maria Guirro Roger Mariné-Casadó Lidón Millá Josep M Alegret Fàtima Sabench Daniel del Castillo María Vinaixa Miguelàngel Rodríguez Xavier Correig Roberto García-álvarez Javier A Menendez Jordi Camps Jorge Joven | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 3 | Morbidity and mortality after D1 and D2 gastrectomy for cancer: Interim analysis of the Italian Gastric Cancer Study Group (IGCSG) randomised surgical trial显示文摘 | M Degiuli M Sasako M Calgaro M Garino F Rebecchi M Mineccia D Scaglione D Andreone A Ponti F Calvo | 2004 | European Journal of Surgical Oncology2004，，3： | 2 |
| 4 | Elimination of organic water pollutants using adsorbents obtained from sewage sludge 显示文摘 | Otero M Rozada F Calvo L F | 2003 | Dyes and Pigments2003，57，： | 1 |
| 5 | Detection of new respiratory viruses in hospitalized infants with bronchiolitis: a three-year r prospective study显示文摘 | Calvo C Pozo F Garcia-Garcia M L | 2010 | Acta Paediatrica2010，99，6： | 1 |
| 6 | Preindustrial to moderninterdecadal variability in coral reef pH显示文摘 | Pelejero C Calvo E McCulloch M T Marshall J F Gagan M K Lough J M Opdyke B N | 2005 | Science2005，309，5744： | 1 |
| 7 | Kinetic and equilibrium modeling of the methylene blue removal from solution by adsorbent materials produced from sewage sludge 显示文摘 | Otero M Rozada F Calvo LF | 2003 | Biochemical Engineering Journal2003，15，1： | 1 |
| 8 | Intedeukin 1-dependent and independent mouse melanoma metastasis显示文摘 | ANASAGASTI M J OLASO E CALVO F | 1997 | J Natl Cancer Inst1997，89，9： | 1 |
| 9 | Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC)显示文摘 | Rocks N Paulissen G Quesada Calvo F | 2006 | Br J Cancer2006，94，5： | 1 |
| 10 | Analysis of the cocombustion of sewage sludge and coal by TG-MS显示文摘 | Orero M Diez C Calvo L F | 2002 | Biomass&Bioenergy2002，22，4： | 1 |
| 11 | Enhanced implementation of blind carrier frequency estimators for QPSK satellite receivers at low SNR显示文摘 | Calvo P M Sevillano J F Velez I | 2005 | IEEE Transaction on Consumer Electronics2005，51，2： | 1 |
| 12 | Kinetics and equilibrium modeling of the methylene blue removal from solution by adsorbent materials produced from sewage sludges 显示文摘 | Otero M Rozada F Calvo L F | 2003 | Biochemical Engineering Journal2003，15，1： | 1 |
| 13 | Analysis of the coeom- bustion of sewage sludge and coal by TG-MS显示文摘 | Otero M Dlez C Calvo L F | 2002 | Bio- mass and Bioenergy2002，22，4： | 1 |
| 14 | Kinetic and equilibrium modelling of the methylene blue removal from solution by adsorbent materials produced from sewage sludges显示文摘 | Otero M Rozada F Calvo L F | 2003 | Biochemical Engineering Journal2003，15，： | 1 |
| 15 | Antiulcerogenic activity of Alchornea castaneaefolia:Effects on somatostatin,gastrin and prostaglandin显示文摘 | Hiruma-Lima C A Calvo T B Rodrigues C M Andrade F D Souza-Brito A R M | 2006 | Journal of Ethnopharmacology2006，104，1： | 1 |
| 16 | Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus:a phaseⅠtumor pharmacodynamic study in patients with advanced solid tumors显示文摘 | TABERNERO J ROJO F CALVO E | 2008 | J Clin Oncol2008，26，10： | 1 |
| 17 | Cervical phrenic nerve block for int ractable hiccups in cancer patient s显示文摘 | Calvo E Fernandez - La Torre F Brugarolas A | 2002 | J Natl Cancer Inst2002，94，15： | 1 |
| 18 | Surfactant activity of a naphthalene degrading Bacillus pumilus strain isolated from oil sludge显示文摘 | Calvo C Toledo F L Gonzalez-lopez J | 2004 | Journal of Biotechnology2004，109，： | 1 |
| 19 | A real-world application of Monte Carlo procedure for debris flow risk assessment显示文摘 | Calvo B Savi F | 2009 | Computers & Geosciences2009，35，5： | 1 |
| 20 | Dose-and sched-ule-dependenl inhibition of ihe mammalian target of tapamycinpathway with everolimus : a phase 1 tumor pharmacodynamic studyin patients with advanced solid tumors 显示文摘 | TABEKNKHO J ROJO F CALVO E | 2008 | J Clin Oncol2008，26，10： | 1 |
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