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| 1 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 2 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 3 | Mitochondrial free radical generation, oxidative stress, and aging 1 1 This article is dedicated to the memory of our dear friend, colleague, and mentor Lars Ernster (1920–1998), in gratitude for all he gave to us.显示文摘 | Enrique Cadenas Kelvin J.A. Davies | 2000 | Free Radical Biology and Medicine2000，，3： | 3 |
| 4 | Cellular titration of apoptosis with steady state concentrations of H2O2: submicromolar levels of H2O2 induce apoptosis through Fenton chemistry independent of the cellular thiol state显示文摘 | Antunes F Cadenas E | 2001 | Free Radic Biol Med2001，30，9： | 2 |
| 5 | Overview of antifungal agents显示文摘 | Thompson GR Cadena J Patttersun TF | 2009 | Clin Chest Med2009，30，2： | 1 |
| 6 | Mitochondrial free radical generation, oxidative stress ,and aging显示文摘 | Cadenas E Davies K J | 2000 | Free Radic Biol Med2000，29，： | 1 |
| 7 | Oxidative stress : damage to intact cells and organs 显示文摘 | Sies H Cadenas E | 1985 | Philos Trans R Soe Lnd B Biol Sci1985，311，1152： | 1 |
| 8 | Solving fuzzy optimization problems by evolutionary algorithms 显示文摘 | F Fimenez J M Cadenas J L Verdegay | 2003 | Information Sciences (S0020-0255)2003，，152： | 1 |
| 9 | The expression of dentin sialophosphoprotein gene in bone显示文摘 | Qin C Brunn JC Cadena E | 2002 | J Dent Res2002，81，6： | 1 |
| 10 | The expression of dentin sialophosphoprotein gene in bone显示文摘 | Qin C Brunn JC Cadena E | 2002 | J Dent Res2002，81，6： | 1 |
| 11 | Michochondrial free radical generation,oxidative stress,and aging 显示文摘 | Cadenas E Davies KJ | 2000 | Radic Biol Med2000，29，34： | 1 |
| 12 | Preoperative serum alpha-L-fucosidase activity as a prognostic marker in colorectal cancer显示文摘 | Ayude D Paez De La Cadena M Martinez-Zorzano VS | 2003 | Oncology2003，64，1： | 1 |
| 13 | Organ cheminescence:Noninvasive assay for oxidation radical reactions显示文摘 | Boveris A Cadenas D Reiter R | 1980 | Proc Natl Acad Sci USA1980，77，1： | 1 |
| 14 | Direct analysis of abscisic acid in crude plant extracts by liquid spray/tandem mass spectrometry 显示文摘 | GOMEZ- CADENAS A POZO O J GARCIA - AU- GUSTIN P | 2002 | Phytochem Anal2002，13，4： | 1 |
| 15 | Estimation of dispersal distances of culex erraticus in a focus of eastern equine encephalitis virus in the southeastern united states 显示文摘 | ESTEP L K BURKETI?-CADENA N D HILL G E | 2010 | J Med Entomol2010，47，6： | 1 |
| 16 | Resveratrol, melatonin, vitamin E, and PBN protect against renal oxidative DNA dama~induced by the kidney carcinogen KBrO3显示文摘 | CADENAS S BARJA G | 1999 | Free Rasic Biol Med1999，26，1112： | 1 |
| 17 | Nitric oxide and cell signaling pathways in mitochondrial-dependent apoptosis显示文摘 | Boyd C S Cadenas E | 2002 | Jour- nal of Biological Chemistry2002，383，34： | 1 |
| 18 | Redox cycles of caffeic acid,a-tocopherol, and ascorbate: implications for protection of low-density lipoproteins against oxidation 显示文摘 | Laranjinha J Cadenas E | 1999 | IUBMB Life1999，48，： | 1 |
| 19 | Using ranking functions in multiobjective fuzzy linear programming显示文摘 | Cadenas J M Verdegay J | 2000 | FSS2000，111，： | 1 |
| 20 | Effect of flavonoids on 2'-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen显示文摘 | Cameiro CD Amorim JC Cadena SM | 2010 | Food Chem Toxicol2010，48，89： | 1 |
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