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| 1 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 2 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 3 | Performance analysis of piezoelectric cantilever bending actuators显示文摘 | WANG Q M CROSS L E | 1998 | Ferroelectrics1998，215，4： | 1 |
| 4 | Assessment of methodologies for colormetric cholesterol assays of meats显示文摘 | Rhee K S Cross H R | 1988 | J Food Sci1988，53，6： | 1 |
| 5 | Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs 显示文摘 | Muralitharan M Cross RF | 1999 | J Nutr1999，129，11： | 1 |
| 6 | System Studies on CO2 Abatement From Power Plant 显示文摘 | Goldthorpe S H Cross P J I Davison J E | 1992 | Energy Convers Mgmt1992，33，58： | 1 |
| 7 | Reverse engineering and design recovery : a taxonomy显示文摘 | Chikofsky E J Cross II J H | 1990 | IEEE Software1990，7，1： | 1 |
| 8 | Polarization and depolarization behavior of hot presses lead lanthanum zirconate titanate ceramics显示文摘 | YAO Xi CHEN Zhi-li Cross L E | 1983 | J Appl Phys1983，54，6： | 1 |
| 9 | Reverse engineering and design recovery : A Taxonomy 显示文摘 | CHIKOFSKY E J CROSS J H | 1990 | IEEE Software1990，，7： | 1 |
| 10 | Fungal bio-transformation of benzo quinoline,benzo quino-line ,and phenanthridine显示文摘 | Sutherland J B Cross E L Heinze T M | 2005 | Appl Microbiol Biotechn-ol2005，67，： | 1 |
| 11 | Nanomechanical analysis of cells from cancer patients显示文摘 | Cross S E Jin Y S Rao J | 2007 | Nature Nanotechnology2007，2，12： | 1 |
| 12 | 显示文摘 | Jang S J Cross L E Wuttig M | 1990 | J Appl Phys1990，68，6： | 1 |
| 13 | A stackable bonding-free flextensional piezoelectric actuator 显示文摘 | LIU Rui-bin CROSS L E | 2000 | Journal of Electroceramics2000，4，： | 1 |
| 14 | Three-dimensional seismic geomorphology of a deep-water slope-channel system:the Sequoia field, offshore west Nile Delta, Egypt显示文摘 | Cross N E Cunningham A Cook R J | 2008 | AAPG Bulletin2008，92，8： | 1 |
| 15 | Arohiteeture and stratigraphy of alluvial deposits, Morrison Formation ( Upper Jurassic), Utah显示文摘 | Kjemperud A V Sehomacker E R Cross T A | 2008 | American Association of Petroleum Geologists Bulletin2008，92，8： | 1 |
| 16 | Reverse engineering and design recovery:A taxonomy 显示文摘 | Cross J H | 1990 | IEEE Software1990，7，1： | 1 |
| 17 | Three-dimen-sional seismic geomorphology of a deep-water slope-channelsystem:The Sequoia field,offshore west Nile Delta,Egypt显示文摘 | Cross N E Cunningham A Cook R J | 2009 | AAPG Bulletin2009，93，： | 1 |
| 18 | 显示文摘 | Pan W y Daam C Q Cross L E | 1989 | J Appl Phys1989，66，12： | 1 |
| 19 | Developing functional outcomes measures for unilateral neglect: A pilot study 显示文摘 | Bowen A Gardener E Cross S | 2005 | Neuropsychol Rehabil2005，15，： | 1 |
| 20 | Graph matching with a dual-step EM algorithm显示文摘 | Cross A D J Hancock E R | 1998 | IEEE Transactions on Pattern Analysis and Machine Intelligence1998，20，11： | 1 |
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