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| 1 | Ⅰ期癌症患者切除淋巴结内隐匿性微小转移癌灶的检查及其临床病理意义显示文摘目的 检查癌症患者切除淋巴结内有无微小癌转移 ,具有临床、病理重要性。方法 350例 期癌症患者包括非小细胞肺癌 94例 ,乳腺癌 112例 ,食管癌 115例及外阴癌 2 9例病理报告无癌转移的淋巴结 3715枚。应用单克隆抗细胞角蛋白 ( AE1/ AE3)、抗上皮细胞膜 ( EMA) ,及多克隆抗角蛋白抗体进行免疫组化染色重新检查。结果 所有病例的 32 .3% ( 113/ 350 )、被检淋巴结的 5.5%( 2 0 3/ 3715)有淋巴结内隐匿性肿瘤转移。肺癌患者及被检淋巴结的阳性率均比其他肿瘤高。肺鳞癌58%、腺癌 53.8%的淋巴结为阳性 ,分别比食管鳞癌 2 2 .5%、外阴鳞癌 10 .3%及乳腺癌 2 7.7%高 ( P<0 .0 5)。部分乳腺癌患者术后随访显示 :淋巴结阳性患者比阴性者预后更差 ( P<0 .0 5)。结论 说明免疫组化技术可大大提高淋巴结微小癌转移的检出率 ,其阳性率的不同可能与患者的临床经过甚至癌患者的死亡率相关联。 | 陈朝伦 卢晓梅 黄绒 黎音 古丽娜尔 沈宝茵 A J Cochran D R Wen W F Coulson | 1997 | 中华肿瘤杂志1997，19，1： | 16 |
| 2 | U-Pb Zircon Age, Geochemical, and Sr-Nd-Pb Isotopic Constraints on the Age and Origin of Mafic Dykes from Eastern Shandong Province, Eastern China显示文摘U-Pb 锆石年龄, geochemical,和从东方山东省的 mafic 女同性恋的 Sr-Nd-Pb 同位素的数据,东方中国此处被报导。激光脱离诱导地联合了从调查 mafic 女同性恋的二件样品的 U-Pb 锆石分析产出一致年龄从 121.9 妈的血浆团 spectrometry (LA-ICP-MS )?????? 猠潨桳湯瑩捩吗? | LIU Shen HU Ruizhong FENG Caixia GAO Shan FENG Guangying LAI Shaocong QI Youqiang Ian M. COULSON YANG Yuhong YANG Chaogui TANG Liang | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 7 |
| 3 | 三峡水轮机的水力设计显示文摘本文介绍了 VGS 三峡联合体在三峡电站左岸厂房水轮机水力开发中采用的水力设计技术,文中阐述了三峡水轮机水力设计中所采用的主要水力设计、流体动力分析软件和三峡水轮机水力设计的主要设计思想和方法,重点介绍了这些软件和设计方法在三峡水轮机转轮和通流部件水力优化设计中的应用。 | 石清华 Stuart Coulson | 2001 | 东方电机2001，，1： | 3 |
| 4 | 阿拉伯世界社交媒体、政治与公共政策的动力显示文摘本文以中东和北非为背景,借鉴经验主义证据对社交媒体进行定义并对其在公共事务职能方面进行研究,依据中东和北非媒体在公共事务方面在当下和未来可能的作用来衡量其社会概念、决策过程及发展建构。本文通过社交媒体对政治和政策的影响,在中东和北非社会进程中所扮演的角色,官方利用社交媒体时的传播方式,对政策制定者的影响以及在收集信息方面的特征这五方面进行分析,为更清晰地了解阿拉伯世界社交媒体对社会进程和政策决策,以及公共政策和价值后果上显现的影响提供视角。 | David Coulson 关涔 | 2014 | 全球传媒学刊2014，0，1： | 3 |
| 5 | 山西省早白垩纪碳酸岩元素同位素和锆石U-Pb定年研究(英文)显示文摘碳酸岩广泛出露在华北克拉通的山西省。此文中,针对研究区的碳酸岩墙,我们给出新的地球化学、Sr-Nd同位素和锆石U-Pb年龄。LA-ICP-MS锆石定年结果显示,该岩墙的侵位年龄为132.9Ma,全岩K-Ar年龄为131.3~132.6 Ma。碳酸岩墙具有非常一致的主量元素组成,富集轻稀土元素和大离子亲石元素(Ba、U、Pb、Sr),以及亏损K和高场强元素(Ta、P和Ti)。另外,该岩墙具有相对一致的(87Sr/86Sr)i(0.7079~0.7083)和负的εNd(t)(-16.7^-15.2)。以上地球化学特征表明,该岩墙为大陆地壳和此大陆岩石圈地幔混合时期,受明显地壳混染的下岩石圈地幔的部分熔融作用。 | 刘燊 冯彩霞 胡瑞忠 赖绍聪 Ian M Coulson 冯光英 杨毓红 | 2014 | 岩石学报2014，30，2： | 3 |
| 6 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 7 | Oxidative stress-induced mitochondrial dysfunction in a normal colon epithelial cell line显示文摘AIM To determine how a normal human colon cell line reacts to microbial challenge as a way to study oxidative stress-induced responses associated with inflammatory bowel disease.METHODS Normal human colon epithelial cells(ATCC?CRL.1790?)were stimulated with either heat killed E.coli or heat killed murine cecal contents(HKC)and examined for several relevant biomarkers associated with inflammation and oxidative stress including cytokine production,mitochondrial autophagy and oxidant status.TNFα,IL-1βand IL-8 protein concentrations were measured within the supernatants.Fluorescent microscopy was performed to quantify the production of reactive oxygen species(ROS)using an oxidation responsive fluorogenic probe.Mitochondrial morphology and mitochondrial membrane potential was assessed by dual staining using COXIV antibody and a dye concentrating in active mitochondria.Mitochondrial ROS scavenger was used to determine the source of ROS in stimulated cells.Autophagy was detected by staining for the presence of autophagic vesicles.Positive controls for autophagy and ROS/RNS experiments were treated with rapamycin and chloroquine.Mitochondrial morphology,ROS production and autophagy microscopy experiments were analyzed using a custom acquisition and analysis microscopy software(Image J).RESULTS Exposing CRL.1790 cells to microbial challenge stimulated cells to produce several relevant biomarkers associated with inflammation and oxidative stress.Heat killed cecal contents treatment induced a 10-12fold increase in IL-8 production by CRL.1790 cells compared to unstimulated controls at 6 and 12 h(P<0.001).Heat killed E.coli stimulation resulted in a4-5 fold increase in IL-8 compared to the unstimulated control cells at each time point(P<0.001).Both heat killed E.coli and HKC stimulated robust ROS production at 6(P<0.001),and 12 h(P<0.01).Mitochondrial morphologic abnormalities were detected at 6 and12 h based on reduced mitochondrial circularity and decreased mitochondrial membrane potential,P<0.01.Microbial stimulation also induced significant autophagy at 6 and 12 h,P<0.01.Lastly,blocking mitochondrial ROS generation using mitochondrial specific ROS scavenger reversed microbial challenge induced mitochondrial morphologic abnormalities and autophagy.CONCLUSION The findings from this study suggest that CRL.1790cells may be a useful alternative to other colon cancer cell lines in studying the mechanisms of oxidative stress events associated with intestinal inflammatory disorders. | Nandakumar Packiriswamy Kari F Coulson Susan J Holcombe Lorraine M Sordillo | 2017 | World Journal of Gastroenterology2017，23，19： | 3 |
| 8 | Two-way coupled fluid structure interaction simulation of a propeller turbine显示文摘 | H Schmucker F Flemming S Coulson | 2010 | IOP Conference Series: Earth and Environmental Science2010，，1： | 2 |
| 9 | An investigation of the biotic factors determining the rates of plant decomposition on blanket bog显示文摘 | COULSON J C BUTTERFIELD J | 1978 | JEcol1978，66，： | 1 |
| 10 | Muscarinic acetylcholine receptors and airway diseases显示文摘 | COULSON FR FRYER AD | 2003 | Pharmacol Ther2003，98，1： | 1 |
| 11 | Colonization of grassland by sown species: dispersal versus microsite limitation in responses to management显示文摘 | Coulson S J Bullock J M & Stevenson M J | 2001 | Journal of Applied Ecology2001，38，： | 1 |
| 12 | The outer bilayer of the adult sehistosome tegument surface has a low turnover rate in vitro and in vivo显示文摘 | Saunders N Wilson RA Coulson PS | 1987 | Mol Biochem Parasitol1987，25，2： | 1 |
| 13 | Supporting the real-time requirements of continuous media in open distributed processing显示文摘 | | 1995 | Computer Net-works and ISDN Systems1995，27，8： | 1 |
| 14 | Muscarinic acetylcholine receptors and air 2 way diseases显示文摘 | Coulson FR Fryer AD | 2003 | Pharmacol Ther2003，98，1： | 1 |
| 15 | Attributing Emotion to Static Body Postures: Recognition Accuracy, Confusions, and Viewpoint Dependence显示文摘 | Mark Coulson | 2004 | Journal of Nonverbal Behavior2004，，2： | 1 |
| 16 | Freeriding on Gnutella revisited:the bell tolls显示文摘 | Hughes D Coulson G Walkerdine J | 2005 | IEEE Distrib Syst Online2005，6，6： | 1 |
| 17 | Spatial cueing in time-space synesthetes:An event-related brain potential study显示文摘 | Teuscher U Brang D Ramachandran V.S Coulson S | | 0，，01： | 1 |
| 18 | Complete sequence of bovine mitochondrial DNA conserved features of the mammalian mitochondrial genome 显示文摘 | Anderson S de Bruijn MH Coulson AR | 1982 | J Mol Biol1982，156，4： | 1 |
| 19 | Residential Investment,Non-residential Investment and GDP显示文摘 | Coulson N E Kim M S | 2000 | Real Estate Economics2000，28，2： | 1 |
| 20 | RNAi-prospects for a general technique for detemaining gene function显示文摘 | Kuwabara PE Coulson A | 2002 | Parasitol Today2002，16，8： | 1 |
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